INSM1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Insulinoma-associated protein 1''' is a [[protein]] that in humans is encoded by the ''INSM1'' [[gene]].<ref name="pmid8188699">{{cite journal |vauthors=Lan MS, Li Q, Lu J, Modi WS, Notkins AL | title = Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1 | journal = J Biol Chem | volume = 269 | issue = 19 | pages = 14170–4 |date=Jun 1994 | pmid = 8188699 | pmc =  | doi =  }}</ref><ref name="pmid16569215">{{cite journal |vauthors=Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS | title = INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases | journal = Biochem J | volume = 397 | issue = 1 | pages = 169–77 |date=Jun 2006 | pmid = 16569215 | pmc = 1479746 | doi = 10.1042/BJ20051669 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INSM1 insulinoma-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642| accessdate = }}</ref>
'''Insulinoma-associated protein 1''' is a [[protein]] that in humans is encoded by the ''INSM1'' [[gene]].<ref name="pmid8188699">{{cite journal | vauthors = Lan MS, Li Q, Lu J, Modi WS, Notkins AL | title = Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 19 | pages = 14170–4 | date = May 1994 | pmid = 8188699 | pmc =  | doi =  }}</ref><ref name="pmid16569215">{{cite journal | vauthors = Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS | title = INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases | journal = The Biochemical Journal | volume = 397 | issue = 1 | pages = 169–77 | date = July 2006 | pmid = 16569215 | pmc = 1479746 | doi = 10.1042/BJ20051669 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INSM1 insulinoma-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3642| access-date = }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.<ref name="entrez"/>
}}


==Interactions==
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.<ref name="entrez"/> <ref>{{cite journal | vauthors = Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF | title = Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections | journal = Modern Pathology | volume = Epub ahead of print | date = August 2018 | pmid = 30154579 | doi = 10.1038/s41379-018-0122-7 }}</ref>
INSM1 has been shown to [[Protein-protein interaction|interact]] with [[SORBS1]].<ref name=pmid12079283>{{cite journal |last=Xie |first=Jingping |authorlink= |author2=Cai Tao |author3=Zhang Honglai |author4=Lan Michael S |author5=Notkins Abner Louis  |date=Jul 2002 |title=The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein |journal=Genomics |volume=80 |issue=1 |pages=54–61 |publisher= |location = United States| issn = 0888-7543| pmid = 12079283 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1006/geno.2002.6800 |pmc=1237014 }}</ref>


==References==
== Interactions ==
 
INSM1 has been shown to [[Protein-protein interaction|interact]] with [[SORBS1]].<ref name=pmid12079283>{{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = July 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800 }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS | title = A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs | journal = The Journal of Biological Chemistry | volume = 267 | issue = 21 | pages = 15252–7 | date = July 1992 | pmid = 1634555 | doi =  }}
| citations =
* {{cite journal | vauthors = Li Q, Notkins AL, Lan MS | title = Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1 | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 3 | pages = 776–81 | date = July 1997 | pmid = 9245732 | doi = 10.1006/bbrc.1997.7054 }}
*{{cite journal   |vauthors=Goto Y, De Silva MG, Toscani A, etal |title=A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. |journal=J. Biol. Chem. |volume=267 |issue= 21 |pages= 15252–7 |year= 1992 |pmid= 1634555 |doi=  }}
* {{cite journal | vauthors = Breslin MB, Zhu M, Notkins AL, Lan MS | title = Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence | journal = Nucleic Acids Research | volume = 30 | issue = 4 | pages = 1038–45 | date = February 2002 | pmid = 11842116 | pmc = 100352 | doi = 10.1093/nar/30.4.1038 }}
*{{cite journal |vauthors=Li Q, Notkins AL, Lan MS |title=Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 776–81 |year= 1997 |pmid= 9245732 |doi= 10.1006/bbrc.1997.7054 }}
* {{cite journal | vauthors = Zhu M, Breslin MB, Lan MS | title = Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells | journal = Pancreas | volume = 24 | issue = 2 | pages = 139–45 | date = March 2002 | pmid = 11854618 | doi = 10.1097/00006676-200203000-00004 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Xie J, Cai T, Zhang H, Lan MS, Notkins AL | title = The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein | journal = Genomics | volume = 80 | issue = 1 | pages = 54–61 | date = July 2002 | pmid = 12079283 | pmc = 1237014 | doi = 10.1006/geno.2002.6800 }}
*{{cite journal  |vauthors=Breslin MB, Zhu M, Notkins AL, Lan MS |title=Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1038–45 |year= 2002 |pmid= 11842116 |doi=10.1093/nar/30.4.1038 | pmc=100352  }}
* {{cite journal | vauthors = Breslin MB, Zhu M, Lan MS | title = NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 38991–7 | date = October 2003 | pmid = 12890672 | pmc = 1236987 | doi = 10.1074/jbc.M306795200 }}
*{{cite journal |vauthors=Zhu M, Breslin MB, Lan MS |title=Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells. |journal=Pancreas |volume=24 |issue= 2 |pages= 139–45 |year= 2002 |pmid= 11854618 |doi=10.1097/00006676-200203000-00004 }}
* {{cite journal | vauthors = Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS | title = Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest | journal = The Journal of Biological Chemistry | volume = 284 | issue = 9 | pages = 5574–81 | date = February 2009 | pmid = 19124461 | pmc = 2645817 | doi = 10.1074/jbc.M808843200 }}
*{{cite journal   |vauthors=Xie J, Cai T, Zhang H, etal |title=The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. |journal=Genomics |volume=80 |issue= 1 |pages= 54–61 |year= 2003 |pmid= 12079283 |doi=10.1006/geno.2002.6800 | pmc=1237014  }}
*{{cite journal |vauthors=Breslin MB, Zhu M, Lan MS |title=NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38991–7 |year= 2003 |pmid= 12890672 |doi= 10.1074/jbc.M306795200 | pmc=1236987 }}
*{{cite journal |author1=Tao Zhang |author2=Breslin MB |author3=Lan MS |title=Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest. |journal=J. Biol. Chem. |volume=284 |issue= 9 |pages= 5574–81 |year= 2009 |pmid= 19124461 |doi= 10.1074/jbc.M808843200 | pmc=2645817 }}
}}
{{refend}}
{{refend}}
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Latest revision as of 07:20, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[1][2][3]

Function

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[3] [4]

Interactions

INSM1 has been shown to interact with SORBS1.[5]

References

  1. ↑ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (May 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry. 269 (19): 14170–4. PMID 8188699.
  2. ↑ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (July 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". The Biochemical Journal. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746. PMID 16569215.
  3. ↑ 3.0 3.1 "Entrez Gene: INSM1 insulinoma-associated 1".
  4. ↑ Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections". Modern Pathology. Epub ahead of print. doi:10.1038/s41379-018-0122-7. PMID 30154579.
  5. ↑ Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.

Further reading

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