CLDN14: Difference between revisions

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*{{cite journal  | vauthors=Hu YH, Warnatz HJ, Vanhecke D |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155  | pmc=1526728 |display-authors=etal}}
*{{cite journal  | vauthors=Hu YH, Warnatz HJ, Vanhecke D |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155  | pmc=1526728 |display-authors=etal}}
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* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 }}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
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* [http://scienceblog.cancerresearchuk.org/2013/06/14/sticky-cells-blood-vessels-and-cancer-the-paradox-of-claudin-14/ Sticky cells, blood vessels and cancer – the paradox of Claudin-14] - Marianne Baker, Cancer Research UK Science Update blog, 14 June 2013
* [http://scienceblog.cancerresearchuk.org/2013/06/14/sticky-cells-blood-vessels-and-cancer-the-paradox-of-claudin-14/ Sticky cells, blood vessels and cancer – the paradox of Claudin-14] - Marianne Baker, Cancer Research UK Science Update blog, 14 June 2013

Latest revision as of 09:11, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (protein)

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Claudin-14 is a protein that in humans is encoded by the CLDN14 gene.[1][2] It belongs to a related family of proteins called claudins.

The protein encoded by CLDN14 is an integral membrane protein and a component of tight junctions, one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets. Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

These junctions are composed of sets of continuous networking protein strands in the outer surface of the cell membrane, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The CLDN14 protein also binds to particular part of a protein called Yes-associated protein, known as its WW domain.

Defects in CLDN14 are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. Two transcript variants encoding the same protein have been found for this gene.[2]

There are also suggestions that CLDN14 plays a role in tumour angiogenesis (blood vessel formation),[3] as deletion of a single copy of this gene leads to tight junction defects and leaky blood vessels in a mouse model.

References

  1. Wilcox ER, Burton QL, Naz S, Riazuddin S, Smith TN, Ploplis B, Belyantseva I, Ben-Yosef T, Liburd NA, Morell RJ, Kachar B, Wu DK, Griffith AJ, Riazuddin S, Friedman TB (Feb 2001). "Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29". Cell. 104 (1): 165–72. doi:10.1016/S0092-8674(01)00200-8. PMID 11163249.
  2. 2.0 2.1 "Entrez Gene: CLDN14 claudin 14".
  3. Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G, et al. (2013). "Stromal Claudin14-Heterozygosity, but Not Deletion, Increases Tumour Blood Leakage without Affecting Tumour Growth". PLoS ONE. 8 (5): e62516. doi:10.1371/journal.pone.0062516. PMC 3652830. PMID 23675413.

External links

Further reading