Zinc finger protein 280b: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Zinc finger protein 280B''' is a [[protein]] that in humans is encoded by the ZNF280B [[gene]].<ref name="entrez">
{{cite web | title = Entrez Gene: Zinc finger protein 280B | url = https://www.ncbi.nlm.nih.gov/gene/140883 }}</ref>


'''Zinc finger protein 280B''' is a [[protein]] that in humans is encoded by the ZNF280B [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Zinc finger protein 280B
| url = https://www.ncbi.nlm.nih.gov/gene/140883
| accessdate = 2016-02-02
}}</ref>


==Function==
The [[protein]] encoded by this [[gene]] is a transcription factor that upregulates expression of [[MDM2]], which negatively regulates [[p53]] expression. This gene is highly expressed in [[prostate cancer]] [[cells]], which leads to a reduction in p53 levels and an increase in growth of the [[cancer cells]]. Several transcript variants have been found for this gene, but only one of them is protein-coding.
 
The [[protein]] encoded by this [[gene]] is a transcription factor that upregulates expression of [[MDM2]], which negatively regulates [[p53]] expression. This gene is highly expressed in [[prostate cancer]] [[cells]], which leads to a reduction in p53 levels and an increase in growth of the [[cancer cells]]. Several transcript variants have been found for this gene, but only one of them is protein-coding.Interestingly, the ZNF208B gene is localized between the variable subgenes for light chain of immunoglobulins (Ig), and it is lost in B cells that rearrange specific lambda variable Ig subgenes <ref>{{cite journal|pmid=23608880 | doi=10.1016/j.leukres.2013.03.018 | volume=37 | title=The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus | year=2013 | journal=Leuk Res | pages=802–8 | last1 = Mraz | first1 = M | last2 = Stano Kozubik | first2 = K | last3 = Plevova | first3 = K | last4 = Musilova | first4 = K | last5 = Tichy | first5 = B | last6 = Borsky | first6 = M | last7 = Kuglik | first7 = P | last8 = Doubek | first8 = M | last9 = Brychtova | first9 = Y | last10 = Mayer | first10 = J | last11 = Pospisilova | first11 = S}}</ref>


== References ==
== References ==
{{reflist}}
{{reflist}}
== Further reading ==
{{refbegin | 2}}
{{refend}}


{{NLM content}}
{{NLM content}}


[[Category:Human proteins]]
[[Category:Human proteins]]


{{gene-22-stub}}
{{gene-22-stub}}

Latest revision as of 12:30, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.[1]

Function

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.

References

  1. ↑ "Entrez Gene: Zinc finger protein 280B".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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