HARS2: Difference between revisions
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'''Probable histidyl-tRNA synthetase, | '''Probable [[histidyl-tRNA synthetase]], [[mitochondria]]l''' is an [[enzyme]] that in [[human]]s is encoded by the ''HARS2'' [[gene]].<ref name="pmid7755634">{{cite journal |vauthors=O'Hanlon TP, Raben N, Miller FW | title = A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS | journal = Biochem Biophys Res Commun | volume = 210 | issue = 2 | pages = 556–66 |date=Jun 1995 | pmid = 7755634 | pmc = | doi =10.1006/bbrc.1995.1696 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23438| accessdate = }}</ref> | ||
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| summary_text = Aminoacyl-tRNA synthetases are a class of enzymes that charge | | summary_text = [[Aminoacyl tRNA synthetase|Aminoacyl-tRNA synthetases]] are a class of enzymes that charge [[tRNA]]s with their cognate [[amino acids]]. The [[protein]] encoded by this gene is an enzyme belonging to the class II family of [[aminoacyl-tRNA]] [[synthetase]]s. Functioning in the [[RNA synthesis|synthesis]] of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of [[protein biosynthesis]]. The gene is located in a head-to-head orientation with HARS on [[chromosome five]], where the homologous genes share a bidirectional promoter.<ref name="entrez">{{cite web | title = Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23438| accessdate = }}</ref> | ||
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Latest revision as of 10:39, 17 December 2018
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Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.[1][2]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.[2]
References
- ↑ O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID 7755634.
- ↑ 2.0 2.1 "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".
Further reading
- Freist W, Verhey JF, Rühlmann A, et al. (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi:10.1515/BC.1999.079. PMID 10430027.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lama J, Trono D (1998). "Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3". J. Virol. 72 (2): 1671–6. PMC 124654. PMID 9445076.
- Tsui HW, Mok S, de Souza L, et al. (1993). "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element". Gene. 131 (2): 201–8. doi:10.1016/0378-1119(93)90294-D. PMID 8406012.
- Raben N, Borriello F, Amin J, et al. (1992). "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases". Nucleic Acids Res. 20 (5): 1075–81. doi:10.1093/nar/20.5.1075. PMC 312093. PMID 1549469.
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