RASGRF2: Difference between revisions
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal |vauthors=Arozarena I, Matallanas D, Berciano MT, etal |title=Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1516–30 |year= 2004 |pmid= 14749369 |doi=10.1128/MCB.24.4.1516-1530.2004 | pmc=344182 }} | *{{cite journal |vauthors=Arozarena I, Matallanas D, Berciano MT, etal |title=Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1516–30 |year= 2004 |pmid= 14749369 |doi=10.1128/MCB.24.4.1516-1530.2004 | pmc=344182 |url=https://digital.csic.es/bitstream/10261/24623/4/Activation%20of%20H-Ras.pdf }} | ||
*{{cite journal |vauthors=Chen H, Suzuki M, Nakamura Y, etal |title=Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. |journal=Oncol. Rep. |volume=15 |issue= 5 |pages= 1281–5 |year= 2006 |pmid= 16596198 |doi= 10.3892/or.15.5.1281}} | *{{cite journal |vauthors=Chen H, Suzuki M, Nakamura Y, etal |title=Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. |journal=Oncol. Rep. |volume=15 |issue= 5 |pages= 1281–5 |year= 2006 |pmid= 16596198 |doi= 10.3892/or.15.5.1281}} | ||
*{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
Latest revision as of 13:41, 4 November 2018
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Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.[1]
RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][1]
Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[2]
References
Further reading
- Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". Genomics. 39 (1): 118–20. doi:10.1006/geno.1996.4484. PMID 9027497.
- Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras". Mol. Cell. Biol. 17 (3): 1396–406. PMC 231864. PMID 9032266.
- Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways". Curr. Biol. 8 (16): 935–8. doi:10.1016/S0960-9822(07)00376-4. PMID 9707409.
- Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf". Mol. Cell. Biol. 19 (7): 4611–22. PMC 84259. PMID 10373510.
- Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways". Eur. J. Biochem. 269 (2): 638–49. doi:10.1046/j.0014-2956.2001.02694.x. PMID 11856323.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors" (PDF). Mol. Cell. Biol. 24 (4): 1516–30. doi:10.1128/MCB.24.4.1516-1530.2004. PMC 344182. PMID 14749369.
- Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer". Oncol. Rep. 15 (5): 1281–5. doi:10.3892/or.15.5.1281. PMID 16596198.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses". Mol. Cell. Biol. 27 (23): 8127–42. doi:10.1128/MCB.00912-07. PMC 2169177. PMID 17923690.
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