CCNC (gene): Difference between revisions

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==Interactions==
==Interactions==
CCNC (gene) has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> and [[Cyclin-dependent kinase 8]].<ref name=pmid11867769/><ref name=pmid9150135>{{cite journal |last=Zhang |first=Y |author2=Iratni R|author3=Erdjument-Bromage H|author4=Tempst P|author5=Reinberg D |date=May 1997 |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex |journal=Cell |volume=89 |issue=3 |pages=357–64 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 9150135 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(00)80216-0 }}</ref><ref name=pmid9710619>{{cite journal |last=Cho |first=H |author2=Orphanides G|author3=Sun X|author4=Yang X J|author5=Ogryzko V|author6=Lees E|author7=Nakatani Y|author8=Reinberg D |date=Sep 1998 |title=A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure |journal=Mol. Cell. Biol. |volume=18 |issue=9 |pages=5355–63 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9710619 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109120 }}</ref><ref name=pmid11416138>{{cite journal |last=Wang |first=G |author2=Cantin G T|author3=Stevens J L|author4=Berk A J |date=Jul 2001 |title=Characterization of Mediator Complexes from HeLa Cell Nuclear Extract |journal=Mol. Cell. Biol. |volume=21 |issue=14 |pages=4604–13 |publisher= |location = United States| issn = 0270-7306| pmid = 11416138 |doi = 10.1128/MCB.21.14.4604-4613.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87123 }}</ref><ref name=pmid7568034>{{cite journal |last=Tassan |first=J P |author2=Jaquenoud M|author3=Léopold P|author4=Schultz S J|author5=Nigg E A |date=Sep 1995 |title=Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=19 |pages=8871–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 7568034 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.92.19.8871 |pmc=41069 }}</ref>
CCNC (gene) has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid11867769>{{cite journal |last=Kang |first=Yun Kyoung |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G  |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue=5 |pages=2642–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode =2002PNAS...99.2642K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=122401 }}</ref> and [[Cyclin-dependent kinase 8]].<ref name=pmid11867769/><ref name=pmid9150135>{{cite journal |last=Zhang |first=Y |author2=Iratni R|author3=Erdjument-Bromage H|author4=Tempst P|author5=Reinberg D |date=May 1997 |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex |journal=Cell |volume=89 |issue=3 |pages=357–64 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 9150135 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(00)80216-0 }}</ref><ref name=pmid9710619>{{cite journal |last=Cho |first=H |author2=Orphanides G|author3=Sun X|author4=Yang X J|author5=Ogryzko V|author6=Lees E|author7=Nakatani Y|author8=Reinberg D |date=Sep 1998 |title=A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure |journal=Mol. Cell. Biol. |volume=18 |issue=9 |pages=5355–63 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9710619 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109120 }}</ref><ref name=pmid11416138>{{cite journal |last=Wang |first=G |author2=Cantin G T|author3=Stevens J L|author4=Berk A J |date=Jul 2001 |title=Characterization of Mediator Complexes from HeLa Cell Nuclear Extract |journal=Mol. Cell. Biol. |volume=21 |issue=14 |pages=4604–13 |publisher= |location = United States| issn = 0270-7306| pmid = 11416138 |doi = 10.1128/MCB.21.14.4604-4613.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87123 }}</ref><ref name=pmid7568034>{{cite journal |last=Tassan |first=J P |author2=Jaquenoud M|author3=Léopold P|author4=Schultz S J|author5=Nigg E A |date=Sep 1995 |title=Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=92 |issue=19 |pages=8871–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 7568034 | bibcode =1995PNAS...92.8871T | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.92.19.8871 |pmc=41069 }}</ref>


==References==
==References==
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| citations =  
| citations =  
*{{cite journal  | vauthors=Nozawa T, Hatano M, Yamamoto H, Kwan T |title=Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II) |journal=Bioinorganic chemistry |volume=5 |issue= 3 |pages= 267–73 |year= 1976 |pmid= 1260071 |doi=10.1016/S0006-3061(00)82025-6  }}
*{{cite journal  | vauthors=Nozawa T, Hatano M, Yamamoto H, Kwan T |title=Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II) |journal=Bioinorganic chemistry |volume=5 |issue= 3 |pages= 267–73 |year= 1976 |pmid= 1260071 |doi=10.1016/S0006-3061(00)82025-6  }}
*{{cite journal  | vauthors=Tassan JP, Jaquenoud M, Léopold P |title=Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8871–5 |year= 1995 |pmid= 7568034 |doi=10.1073/pnas.92.19.8871  | pmc=41069  |display-authors=etal}}
*{{cite journal  | vauthors=Tassan JP, Jaquenoud M, Léopold P |title=Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8871–5 |year= 1995 |pmid= 7568034 |doi=10.1073/pnas.92.19.8871  | pmc=41069  |display-authors=etal|bibcode=1995PNAS...92.8871T}}
*{{cite journal  | vauthors=Demetrick DJ, Matsumoto S, Hannon GJ |title=Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3) |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3–4 |pages= 190–2 |year= 1995 |pmid= 7698009 |doi=10.1159/000133960  |display-authors=etal}}
*{{cite journal  | vauthors=Demetrick DJ, Matsumoto S, Hannon GJ |title=Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3) |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3–4 |pages= 190–2 |year= 1995 |pmid= 7698009 |doi=10.1159/000133960  |display-authors=etal}}
*{{cite journal  | vauthors=Yoshizumi M, Lee WS, Hsieh CM |title=Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts |journal=J. Clin. Invest. |volume=95 |issue= 5 |pages= 2275–80 |year= 1995 |pmid= 7738192 |doi=10.1172/JCI117918  | pmc=295840  |display-authors=etal}}
*{{cite journal  | vauthors=Yoshizumi M, Lee WS, Hsieh CM |title=Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts |journal=J. Clin. Invest. |volume=95 |issue= 5 |pages= 2275–80 |year= 1995 |pmid= 7738192 |doi=10.1172/JCI117918  | pmc=295840  |display-authors=etal}}
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*{{cite journal  | vauthors=Gu W, Malik S, Ito M |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1  |display-authors=etal}}
*{{cite journal  | vauthors=Gu W, Malik S, Ito M |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1  |display-authors=etal}}
*{{cite journal  | vauthors=Ito M, Yuan CX, Malik S |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=10.1016/S1097-2765(00)80463-3  |display-authors=etal}}
*{{cite journal  | vauthors=Ito M, Yuan CX, Malik S |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=10.1016/S1097-2765(00)80463-3  |display-authors=etal}}
*{{cite journal  | vauthors=Rachez C, Lemon BD, Suldan Z |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 |display-authors=etal}}
*{{cite journal  | vauthors=Rachez C, Lemon BD, Suldan Z |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 |display-authors=etal|bibcode=1999Natur.398..824R }}
*{{cite journal  | vauthors=Wang G, Cantin GT, Stevens JL, Berk AJ |title=Characterization of Mediator Complexes from HeLa Cell Nuclear Extract |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4604–13 |year= 2001 |pmid= 11416138 |doi= 10.1128/MCB.21.14.4604-4613.2001  | pmc=87123 }}
*{{cite journal  | vauthors=Wang G, Cantin GT, Stevens JL, Berk AJ |title=Characterization of Mediator Complexes from HeLa Cell Nuclear Extract |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4604–13 |year= 2001 |pmid= 11416138 |doi= 10.1128/MCB.21.14.4604-4613.2001  | pmc=87123 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | vauthors=Sato S, Tomomori-Sato C, Banks CA |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 |display-authors=etal}}
*{{cite journal  | vauthors=Sato S, Tomomori-Sato C, Banks CA |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 |display-authors=etal}}
*{{cite journal  | vauthors=Ueberham U, Hessel A, Arendt T |title=Cyclin C expression is involved in the pathogenesis of Alzheimer's disease |journal=Neurobiol. Aging |volume=24 |issue= 3 |pages= 427–35 |year= 2003 |pmid= 12600719 |doi=10.1016/S0197-4580(02)00132-X  }}
*{{cite journal  | vauthors=Ueberham U, Hessel A, Arendt T |title=Cyclin C expression is involved in the pathogenesis of Alzheimer's disease |journal=Neurobiol. Aging |volume=24 |issue= 3 |pages= 427–35 |year= 2003 |pmid= 12600719 |doi=10.1016/S0197-4580(02)00132-X  }}

Latest revision as of 01:05, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Cyclin-C is a protein that in humans is encoded by the CCNC gene.[1][2]

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

CCNC (gene) has been shown to interact with Estrogen receptor alpha[3] and Cyclin-dependent kinase 8.[3][4][5][6][7]

References

  1. ↑ Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066.
  2. ↑ 2.0 2.1 "Entrez Gene: CCNC cyclin C".
  3. ↑ 3.0 3.1 Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
  4. ↑ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. UNITED STATES. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135.
  5. ↑ Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. UNITED STATES. 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619.
  6. ↑ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. United States. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
  7. ↑ Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034.

External links

Further reading



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