Butyrophilin, subfamily 2, member A2: Difference between revisions

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{{Infobox_gene}}
'''Butyrophilin subfamily 2 member A2''' is a [[protein]] that in humans is encoded by the ''BTN2A2'' [[gene]].<ref name="pmid10354554">{{cite journal | vauthors = Henry J, Miller MM, Pontarotti P | title = Structure and evolution of the extended B7 family | journal = Immunol Today | volume = 20 | issue = 6 | pages = 285–8 |date=Jul 1999 | pmid = 10354554 | pmc =  | doi =10.1016/S0167-5699(98)01418-2 }}</ref><ref name="pmid9149941">{{cite journal | vauthors = Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, ((Domingo R Jr)), Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN | title = A 1.1-Mb transcript map of the hereditary hemochromatosis locus | journal = Genome Res | volume = 7 | issue = 5 | pages = 441–56 |date=Aug 1997 | pmid = 9149941 | pmc =  | doi = 10.1101/gr.7.5.441}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10385| accessdate = }}</ref>
'''Butyrophilin subfamily 2 member A2''' is a [[protein]] that in humans is encoded by the ''BTN2A2'' [[gene]].<ref name="pmid10354554">{{cite journal | vauthors = Henry J, Miller MM, Pontarotti P | title = Structure and evolution of the extended B7 family | journal = Immunology Today | volume = 20 | issue = 6 | pages = 285–8 | date = June 1999 | pmid = 10354554 | pmc =  | doi = 10.1016/S0167-5699(98)01418-2 }}</ref><ref name="pmid9149941">{{cite journal | vauthors = Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN | title = A 1.1-Mb transcript map of the hereditary hemochromatosis locus | journal = Genome Research | volume = 7 | issue = 5 | pages = 441–56 | date = May 1997 | pmid = 9149941 | pmc =  | doi = 10.1101/gr.7.5.441 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10385| accessdate = }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.<ref name="entrez"/>
}}


==References==
[[Butyrophilin]] is the major protein associated with [[fat]] droplets in the [[milk]]. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on [[chromosome 6]], consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the [[immunoglobulin]] gene superfamily. The encoded protein is a type 1 receptor [[glycoprotein]] involved in [[lipid]], [[fatty-acid]] and [[sterol]] metabolism. Several alternatively spliced [[transcript variants]] of this gene have been described, but the full-length nature of some variants has not been determined.<ref name="entrez"/>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A | title = A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane | journal = Proteomics | volume = 2 | issue = 7 | pages = 850–6 | date = July 2002 | pmid = 12124930 | doi = 10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C }}
| citations =
* {{cite journal | vauthors = Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J | title = The cluster of BTN genes in the extended major histocompatibility complex | journal = Genomics | volume = 71 | issue = 3 | pages = 351–62 | date = February 2001 | pmid = 11170752 | doi = 10.1006/geno.2000.6406 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Cavaletto M, Giuffrida MG, Fortunato D |title=A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane. |journal=Proteomics |volume=2 |issue= 7 |pages= 850–6 |year= 2003 |pmid= 12124930 |doi= 10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C |display-authors=etal}}
*{{cite journal | vauthors=Rhodes DA, Stammers M, Malcherek G |title=The cluster of BTN genes in the extended major histocompatibility complex. |journal=Genomics |volume=71 |issue= 3 |pages= 351–62 |year= 2001 |pmid= 11170752 |doi= 10.1006/geno.2000.6406 |display-authors=etal}}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{UCSC genome browser|BTN2A2}}
* {{UCSC genome browser|BTN2A2}}
* {{UCSC gene details|BTN2A2}}
* {{UCSC gene details|BTN2A2}}


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Latest revision as of 19:33, 16 February 2018

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.[1][2][3]

Function

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[3]

References

  1. ↑ Henry J, Miller MM, Pontarotti P (June 1999). "Structure and evolution of the extended B7 family". Immunology Today. 20 (6): 285–8. doi:10.1016/S0167-5699(98)01418-2. PMID 10354554.
  2. ↑ Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (May 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Research. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
  3. ↑ 3.0 3.1 "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".

Further reading

  • Cavaletto M, Giuffrida MG, Fortunato D, Gardano L, Dellavalle G, Napolitano L, Giunta C, Bertino E, Fabris C, Conti A (July 2002). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane". Proteomics. 2 (7): 850–6. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C. PMID 12124930.
  • Rhodes DA, Stammers M, Malcherek G, Beck S, Trowsdale J (February 2001). "The cluster of BTN genes in the extended major histocompatibility complex". Genomics. 71 (3): 351–62. doi:10.1006/geno.2000.6406. PMID 11170752.

External links


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