'''Sestrin 1''', also known as '''[[p53]]-regulated protein PA26''', is a [[protein]] that in humans is encoded by the ''SESN1'' [[gene]].
'''Sestrin 1''', also known as '''[[p53]]-regulated protein PA26''', is a [[protein]] that in humans is encoded by the ''SESN1'' [[gene]].
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress.
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress.
The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene..<ref name="entrez">{{cite web | title = Entrez Gene: sestrin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27244| accessdate = }}</ref><ref name="pmid7938006">{{cite journal | vauthors = Buckbinder L, Talbott R, Seizinger BR, Kley N | title = Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 22 | pages = 10640–4 | date = October 1994 | pmid = 7938006 | pmc = 45077 | doi = 10.1073/pnas.91.22.10640 }}</ref><ref name="pmid9926927">{{cite journal | vauthors = Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N | title = PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes | journal = Oncogene | volume = 18 | issue = 1 | pages = 127–37 | date = January 1999 | pmid = 9926927 | doi = 10.1038/sj.onc.1202274 }}</ref>
The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: sestrin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27244| accessdate = }}</ref><ref name="pmid7938006">{{cite journal | vauthors = Buckbinder L, Talbott R, Seizinger BR, Kley N | title = Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 22 | pages = 10640–4 | date = October 1994 | pmid = 7938006 | pmc = 45077 | doi = 10.1073/pnas.91.22.10640 }}</ref><ref name="pmid9926927">{{cite journal | vauthors = Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N | title = PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes | journal = Oncogene | volume = 18 | issue = 1 | pages = 127–37 | date = January 1999 | pmid = 9926927 | doi = 10.1038/sj.onc.1202274 }}</ref>
Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1gene.
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress.
The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[1][2][3]
↑Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID9926927.
Further reading
Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. doi:10.1126/science.1095569. PMID15105503.
Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID12607115.
