ARHGEF5: Difference between revisions
Jump to navigation
Jump to search
m (Bot: HTTP→HTTPS) |
imported>Onel5969 m (Disambiguating links to Rho GTPase (link changed to Rho family of GTPases) using DisamAssist.) |
||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
'''Rho guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''ARHGEF5'' [[gene]].<ref name="pmid8134109">{{cite journal | vauthors = Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T | title = Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins | journal = Oncogene | volume = 9 | issue = 4 | pages = 1057–63 |date=Apr 1994 | pmid = 8134109 | pmc = | doi = }}</ref><ref name="pmid7656213">{{cite journal | vauthors = Takai S, Chan AM, Yamada K, Miki T | title = Assignment of the human TIM proto-oncogene to 7q33→q35 | journal = Cancer Genet Cytogenet | volume = 83 | issue = 1 | pages = 87–9 |date=Oct 1995 | pmid = 7656213 | pmc = | doi =10.1016/S0165-4608(95)00017-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7984| accessdate = }}</ref> | '''Rho guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''ARHGEF5'' [[gene]].<ref name="pmid8134109">{{cite journal | vauthors = Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T | title = Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins | journal = Oncogene | volume = 9 | issue = 4 | pages = 1057–63 |date=Apr 1994 | pmid = 8134109 | pmc = | doi = }}</ref><ref name="pmid7656213">{{cite journal | vauthors = Takai S, Chan AM, Yamada K, Miki T | title = Assignment of the human TIM proto-oncogene to 7q33→q35 | journal = Cancer Genet Cytogenet | volume = 83 | issue = 1 | pages = 87–9 |date=Oct 1995 | pmid = 7656213 | pmc = | doi =10.1016/S0165-4608(95)00017-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7984| accessdate = }}</ref> | ||
| Line 6: | Line 6: | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.<ref name="entrez" /> | | summary_text = [[Rho family of GTPases|Rho GTPases]] play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through [[G protein-coupled receptors]]. The encoded protein may form a complex with [[G proteins]] and stimulate Rho-dependent signals. This protein may be involved in the control of [[cytoskeletal]] organization.<ref name="entrez" /> | ||
}} | }} | ||
Latest revision as of 12:46, 20 February 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[1][2][3]
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[3]
References
- ↑ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109.
- ↑ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213.
- ↑ 3.0 3.1 "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5".
External links
- Human ARHGEF5 genome location and ARHGEF5 gene details page in the UCSC Genome Browser.
Further reading
- Snyder JT, Worthylake DK, Rossman KL, et al. (2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984.
- Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Umetsu DT, Dekruyff RH (2005). "Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment". Ann. N. Y. Acad. Sci. 1029 (1): 88–93. doi:10.1196/annals.1309.012. PMID 15681748.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
 | This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. |