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== MAFA assists in insulin regulation ==
== MAFA assists in insulin regulation ==
An [[in vivo]] study on mice proved MafA binds to the promoter in an [[insulin]] gene to regulate insulin transcription in response to serum glucose levels.<ref>{{Cite journal|last=Zhang|last2=Moriguchi|title=MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion|journal=Mol. Cell. Biol.|volume=25|pmid=15923615|doi=10.1128/MCB.25.12.4969-4976.2005|pmc=1140590|pages=4969–4976}}</ref> MafA is a  [[B cell|β cell]]-specific activator, which differentiates it from other [[transcription factor]]s involved with insulin [[gene expression]].<ref>{{Cite journal|last=Matsuoka|last2=Artner|title=The MafA transcription factor appears to be responsible for tissue-specific expression of insulin|journal=Proc. Natl. Acad. Sci. U.S.A.|volume=101|pmc=365722|pmid=14973194|doi=10.1073/pnas.0306233101|date=March 2004|pages=2930–3}}</ref> It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell [[metabolism]].<ref>{{Cite journal|last=Wang|last2=Kataoka|title=MAFA controls genes implicated in insulin biosynthesis and secretion.|journal=Diabetologia|volume=50|pmc=2196442|pmid=17149590|doi=10.1007/s00125-006-0490-2|year=2007|pages=348–58}}</ref> The amount of MafA in the β cells is regulated by levels of glucose and [[oxidative stress]].<ref name=":0">{{Cite journal|last=Aramata|last2=Han|title=Roles and Regulation of Transcription Factor MafA in Islet β-cells|journal=Endocr. J.|volume=54|pmid=17785922|pages=659–66|doi=10.1507/endocrj.kr-101}}</ref>
An [[in vivo]] study on mice proved MafA binds to the promoter in an [[insulin]] gene to regulate insulin transcription in response to serum glucose levels.<ref>{{Cite journal|last=Zhang|last2=Moriguchi|title=MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion|journal=Mol. Cell. Biol.|volume=25|pmid=15923615|doi=10.1128/MCB.25.12.4969-4976.2005|pmc=1140590|pages=4969–4976}}</ref> MafA is a  [[B cell|β cell]]-specific activator, which differentiates it from other [[transcription factor]]s involved with insulin [[gene expression]].<ref>{{Cite journal|last=Matsuoka|last2=Artner|title=The MafA transcription factor appears to be responsible for tissue-specific expression of insulin|journal=Proc. Natl. Acad. Sci. U.S.A.|volume=101|pmc=365722|pmid=14973194|doi=10.1073/pnas.0306233101|date=March 2004|pages=2930–3|bibcode=2004PNAS..101.2930M}}</ref> It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell [[metabolism]].<ref>{{Cite journal|last=Wang|last2=Kataoka|title=MAFA controls genes implicated in insulin biosynthesis and secretion.|journal=Diabetologia|volume=50|pmc=2196442|pmid=17149590|doi=10.1007/s00125-006-0490-2|year=2007|pages=348–58}}</ref> The amount of MafA in the β cells is regulated by levels of glucose and [[oxidative stress]].<ref name=":0">{{Cite journal|last=Aramata|last2=Han|title=Roles and Regulation of Transcription Factor MafA in Islet β-cells|journal=Endocr. J.|volume=54|pmid=17785922|pages=659–66|doi=10.1507/endocrj.kr-101}}</ref>
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*{{cite journal  |vauthors=Benkhelifa S, Provot S, Nabais E, etal |title=Phosphorylation of MafA is essential for its transcriptional and biological properties. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4441–52 |year= 2001 |pmid= 11416124 |doi= 10.1128/MCB.21.14.4441-4452.2001  | pmc=87104 }}
*{{cite journal  |vauthors=Benkhelifa S, Provot S, Nabais E, etal |title=Phosphorylation of MafA is essential for its transcriptional and biological properties. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4441–52 |year= 2001 |pmid= 11416124 |doi= 10.1128/MCB.21.14.4441-4452.2001  | pmc=87104 }}
*{{cite journal  |vauthors=Olbrot M, Rud J, Moss LG, Sharma A |title=Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6737–42 |year= 2002 |pmid= 12011435 |doi= 10.1073/pnas.102168499  | pmc=124472 }}
*{{cite journal  |vauthors=Olbrot M, Rud J, Moss LG, Sharma A |title=Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6737–42 |year= 2002 |pmid= 12011435 |doi= 10.1073/pnas.102168499  | pmc=124472 |bibcode=2002PNAS...99.6737O }}
*{{cite journal  |vauthors=Kataoka K, Han SI, Shioda S, etal |title=MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49903–10 |year= 2003 |pmid= 12368292 |doi= 10.1074/jbc.M206796200 }}
*{{cite journal  |vauthors=Kataoka K, Han SI, Shioda S, etal |title=MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49903–10 |year= 2003 |pmid= 12368292 |doi= 10.1074/jbc.M206796200 }}
*{{cite journal  |vauthors=Matsuoka TA, Artner I, Henderson E, etal |title=The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 9 |pages= 2930–3 |year= 2004 |pmid= 14973194 |doi= 10.1073/pnas.0306233101  | pmc=365722 }}
*{{cite journal  |vauthors=Matsuoka TA, Artner I, Henderson E, etal |title=The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 9 |pages= 2930–3 |year= 2004 |pmid= 14973194 |doi= 10.1073/pnas.0306233101  | pmc=365722 |bibcode=2004PNAS..101.2930M }}
*{{cite journal  |vauthors=Kaneto H, Matsuoka TA, Nakatani Y, etal |title=A crucial role of MafA as a novel therapeutic target for diabetes. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15047–52 |year= 2005 |pmid= 15664997 |doi= 10.1074/jbc.M412013200 }}
*{{cite journal  |vauthors=Kaneto H, Matsuoka TA, Nakatani Y, etal |title=A crucial role of MafA as a novel therapeutic target for diabetes. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15047–52 |year= 2005 |pmid= 15664997 |doi= 10.1074/jbc.M412013200 }}
*{{cite journal  |vauthors=Harmon JS, Stein R, Robertson RP |title=Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11107–13 |year= 2005 |pmid= 15664999 |doi= 10.1074/jbc.M410345200 }}
*{{cite journal  |vauthors=Harmon JS, Stein R, Robertson RP |title=Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 11107–13 |year= 2005 |pmid= 15664999 |doi= 10.1074/jbc.M410345200 }}

Latest revision as of 08:46, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor MafA is a protein that in humans is encoded by the MAFA gene.[1] It is a member of the Maf family of transcription factors.[2]

MAFA assists in insulin regulation

An in vivo study on mice proved MafA binds to the promoter in an insulin gene to regulate insulin transcription in response to serum glucose levels.[3] MafA is a β cell-specific activator, which differentiates it from other transcription factors involved with insulin gene expression.[4] It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell metabolism.[5] The amount of MafA in the β cells is regulated by levels of glucose and oxidative stress.[2]


Interactions

MafA (gene) has been shown to interact with NEUROD1[6] and Pdx1.[6] MafA works with Pdx1 to activate the insulin gene.[2]

References

  1. "Entrez Gene: MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)".
  2. 2.0 2.1 2.2 Aramata; Han. "Roles and Regulation of Transcription Factor MafA in Islet β-cells". Endocr. J. 54: 659–66. doi:10.1507/endocrj.kr-101. PMID 17785922.
  3. Zhang; Moriguchi. "MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion". Mol. Cell. Biol. 25: 4969–4976. doi:10.1128/MCB.25.12.4969-4976.2005. PMC 1140590. PMID 15923615.
  4. Matsuoka; Artner (March 2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101: 2930–3. Bibcode:2004PNAS..101.2930M. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
  5. Wang; Kataoka (2007). "MAFA controls genes implicated in insulin biosynthesis and secretion". Diabetologia. 50: 348–58. doi:10.1007/s00125-006-0490-2. PMC 2196442. PMID 17149590.
  6. 6.0 6.1 Zhao, Li; Guo Min; Matsuoka Taka-Aki; Hagman Derek K; Parazzoli Susan D; Poitout Vincent; Stein Roland (Mar 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". J. Biol. Chem. United States. 280 (12): 11887–94. doi:10.1074/jbc.M409475200. ISSN 0021-9258. PMID 15665000.

Further reading