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{{Infobox_gene}}
{{Infobox_gene}}
'''Tonsoku-like, DNA repair protein''' is a [[protein]] that in humans is encoded by the TONSL [[gene]].<ref name="entrez">
{{cite web | title = Entrez Gene: Tonsoku-like, DNA repair protein | url = https://www.ncbi.nlm.nih.gov/gene/4796 }}</ref>


'''Tonsoku-like, DNA repair protein''' is a [[protein]] that in humans is encoded by the TONSL [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Tonsoku-like, DNA repair protein
| url = https://www.ncbi.nlm.nih.gov/gene/4796
| accessdate = 2013-07-22 <!-- T22:02:26.363325-08:00 -->
}}</ref>


==Function==
The protein encoded by this gene is thought to be a negative regulator of [[NF-kappa-B]] mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the [[cytoplasm]], preventing them from entering the nucleus and interacting with the [[DNA]]. [[Phosphorylation]] of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
 
The protein encoded by this gene is thought to be a negative regulator of [[NF-kappa-B]] mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the [[cytoplasm]], preventing them from entering the nucleus and interacting with the [[DNA]]. [[Phosphorylation]] of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination  :: BC008782.2 [ECO:0000332] RNAseq introns              :: mixed/partial sample support                                ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END##


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A | title = Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply | journal = The EMBO Journal | volume = 31 | issue = 8 | pages = 2013–23 | date = April 2012 | pmid = 22407294 | pmc = 3343338 | doi = 10.1038/emboj.2012.55 }}
| last1 = Ask | first1 = K.
* {{cite journal | vauthors = Norman DA, Barton PJ | title = Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2) | journal = Annals of Human Genetics | volume = 64 | issue = Pt 1 | pages = 15–23 | date = January 2000 | pmid = 11246458 | pmc =  | doi = 10.1017/S0003480000007910 }}
| last2 = Jasencakova | first2 = Z.
* {{cite journal | vauthors = Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J | title = Identification of the MMS22L-TONSL complex that promotes homologous recombination | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 632–44 | date = November 2010 | pmid = 21055984 | pmc = | doi = 10.1016/j.molcel.2010.10.023 }}
| last3 = Menard | first3 = P.
* {{cite journal | vauthors = O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW | title = A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 645–57 | date = November 2010 | pmid = 21055985 | pmc = 3006237 | doi = 10.1016/j.molcel.2010.10.022 }}
| last4 = Feng | first4 = Y.
* {{cite journal | vauthors = O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D | title = The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 619–31 | date = November 2010 | pmid = 21055983 | pmc = 3031522 | doi = 10.1016/j.molcel.2010.10.024 }}
| last5 = Almouzni | first5 = G. V.
* {{cite journal | vauthors = Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Walley A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott JA, Hill AV | title = Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study | journal = Critical Care | volume = 14 | issue = 6 | pages = R227 | year = 2010 | pmid = 21171993 | pmc = 3220025 | doi = 10.1186/cc9377 }}
| last6 = Groth | first6 = A.
* {{cite journal | vauthors = Ray P, Zhang DH, Elias JA, Ray A | title = Cloning of a differentially expressed I kappa B-related protein | journal = The Journal of Biological Chemistry | volume = 270 | issue = 18 | pages = 10680–5 | date = May 1995 | pmid = 7738005 | doi = 10.1074/jbc.270.18.10680 }}
| doi = 10.1038/emboj.2012.55
* {{cite journal | vauthors = Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M | title = RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells | journal = The EMBO Journal | volume = 29 | issue = 24 | pages = 4210–22 | date = December 2010 | pmid = 21113133 | pmc = 3018799 | doi = 10.1038/emboj.2010.304 }}
| title = Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply  
| journal = The EMBO Journal  
| volume = 31  
| issue = 8  
| pages = 2013–2023
| year = 2012  
| pmid = 22407294  
| pmc =3343338  
}}
*{{Cite journal  
| last1 = Norman | first1 = D. A.
| last2 = Barton | first2 = P. J.
| title = Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2)  
| journal = Annals of Human Genetics  
| volume = 64  
| issue = Pt 1  
| pages = 15–23  
| year = 2000  
| doi = 10.1017/S0003480000007910  
| pmid = 11246458
| pmc =
}}
*{{Cite journal  
| last1 = Duro | first1 = E.
| last2 = Lundin | first2 = C.
| last3 = Ask | first3 = K.
| last4 = Sanchez-Pulido | first4 = L.
| last5 = MacArtney | first5 = T. J.
| last6 = Toth | first6 = R.
| last7 = Ponting | first7 = C. P.
| last8 = Groth | first8 = A.
| last9 = Helleday | first9 = T.
| doi = 10.1016/j.molcel.2010.10.023
| last10 = Rouse | first10 = J.
| title = Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination
| journal = Molecular Cell  
| volume = 40  
| issue = 4  
| pages = 632–644
| year = 2010  
| pmid = 21055984  
| pmc =  
}}
*{{Cite journal  
| last1 = O'Connell | first1 = B. C.
| last2 = Adamson | first2 = B.
| last3 = Lydeard | first3 = J. R.
| last4 = Sowa | first4 = M. E.
| last5 = Ciccia | first5 = A.
| last6 = Bredemeyer | first6 = A. L.
| last7 = Schlabach | first7 = M.
| last8 = Gygi | first8 = S. P.
| last9 = Elledge | first9 = S. J.
| doi = 10.1016/j.molcel.2010.10.022
| last10 = Harper | first10 = J. W.
| title = A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability
| journal = Molecular Cell  
| volume = 40  
| issue = 4  
| pages = 645–657
| year = 2010  
| pmid = 21055985  
| pmc =3006237  
}}
*{{Cite journal  
| last1 = O'Donnell | first1 = L.
| last2 = Panier | first2 = S.
| last3 = Wildenhain | first3 = J.
| last4 = Tkach | first4 = J. M.
| last5 = Al-Hakim | first5 = A.
| last6 = Landry | first6 = M. C.
| last7 = Escribano-Diaz | first7 = C.
| last8 = Szilard | first8 = R. K.
| last9 = Young | first9 = J. T. F.
| last10 = Munro  
| doi = 10.1016/j.molcel.2010.10.024 | first10 = M.
| last11 = Canny | first11 = M. D.
| last12 = Kolas | first12 = N. K.
| last13 = Zhang | first13 = W.
| last14 = Harding | first14 = S. M.
| last15 = Ylanko | first15 = J.
| last16 = Mendez | first16 = M.
| last17 = Mullin | first17 = M.
| last18 = Sun | first18 = T.
| last19 = Habermann | first19 = B.
| last20 = Datti | first20 = A.
| last21 = Bristow | first21 = R. G.
| last22 = Gingras | first22 = A. C.
| last23 = Tyers | first23 = M. D.
| last24 = Brown | first24 = G. W.
| last25 = Durocher | first25 = D.
| title = The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination
| journal = Molecular Cell  
| volume = 40  
| issue = 4  
| pages = 619–631
| year = 2010  
| pmid = 21055983  
| pmc =3031522  
}}
*{{Cite journal  
| last1 = Chapman | first1 = S. J.
| last2 = Khor | first2 = C. C.
| last3 = Vannberg | first3 = F. O.
| last4 = Rautanen | first4 = A.
| last5 = Walley | first5 = A.
| last6 = Segal | first6 = S.
| last7 = Moore | first7 = C. E.
| last8 = Davies | first8 = R. J.
| last9 = Day | first9 = N. P.
| doi = 10.1186/cc9377
| last10 = Peshu | first10 = N.
| last11 = Crook | first11 = D. W.
| last12 = Berkley | first12 = J. A.
| last13 = Williams | first13 = T. N.
| last14 = Scott | first14 = J.
| last15 = Hill | first15 = A. V.
| title = Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: A genetic association study  
| journal = Critical Care  
| volume = 14  
| issue = 6  
| pages = R227  
| year = 2010  
| pmid = 21171993  
| pmc =3220025  
}}
*{{Cite journal  
| doi = 10.1074/jbc.270.18.10680
| last1 = Ray | first1 = P.
| last2 = Zhang | first2 = D. H.
| last3 = Elias | first3 = J. A.
| last4 = Ray | first4 = A.
| title = Cloning of a differentially expressed I kappa B-related protein  
| journal = The Journal of Biological Chemistry  
| volume = 270  
| issue = 18  
| pages = 10680–10685
| year = 1995  
| pmid = 7738005
}}
*{{Cite journal  
| last1 = Piwko | first1 = W.
| last2 = Olma | first2 = M. H.
| last3 = Held | first3 = M.
| last4 = Bianco | first4 = J. N.
| last5 = Pedrioli | first5 = P. G. A.
| last6 = Hofmann | first6 = K.
| last7 = Pasero | first7 = P.
| last8 = Gerlich | first8 = D. W.
| last9 = Peter | first9 = M.
| doi = 10.1038/emboj.2010.304
| title = RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells  
| journal = The EMBO Journal  
| volume = 29  
| issue = 24  
| pages = 4210–4222
| year = 2010  
| pmid = 21113133  
| pmc =3018799  
}}
 
{{refend}}
{{refend}}


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[[Category:Genes]]
[[Category:Genes]]
[[Category:Human proteins]]
[[Category:Human proteins]]


{{gene-8-stub}}
{{gene-8-stub}}

Latest revision as of 08:49, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tonsoku-like, DNA repair protein is a protein that in humans is encoded by the TONSL gene.[1]

Function

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.

References

  1. ↑ "Entrez Gene: Tonsoku-like, DNA repair protein".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=TONSL&oldid=1523915"