CDKN2BAS: Difference between revisions

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'''CDKN2B-AS''', also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 [[exons]], spanning 126.3kb in the [[genome]], and its spliced product is a 3834bp [[RNA]]. It is located within the p15/[[CDKN2B]]-p16/[[P16 (gene)|CDKN2A]]-p14/ARF gene cluster, in the [[antisense]] direction. [[Single-nucleotide polymorphism|Single nucleotide polymorphisms]] (SNPs) which alter the expression of CDKN2B-AS are associated with many diseases, including [[coronary artery disease]], [[diabetes]] and many [[cancers]].<ref name="pmid20386740">{{cite journal |vauthors=Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B |title=Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression |journal=PLoS Genet. |volume=6 |issue=4 |pages=e1000899 |year=2010 |pmid=20386740 |pmc=2851566 |doi=10.1371/journal.pgen.1000899 |url= |editor1-last=Gibson |editor1-first=Greg}}</ref> It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to [[SUZ12]], a component of [[PRC2|polycomb repression complex 2]] and through these interactions is involved in [[Transcription (genetics)|transcriptional]] repression.<ref name="pmid20541999">{{cite journal |vauthors=Yap KL, Li S, Muñoz-Cabello AM |title=Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a |journal=Mol. Cell |volume=38 |issue=5 |pages=662–74 |date=June 2010 |pmid=20541999 |doi=10.1016/j.molcel.2010.03.021 |url= |pmc=2886305|display-authors=etal}}</ref><ref name="pmid21151178">{{cite journal |vauthors=Kotake Y, Nakagawa T, Kitagawa K |title=Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene |journal=Oncogene |volume= 30|issue= 16|pages= 1956–1962|date=December 2010 |pmid=21151178 |doi=10.1038/onc.2010.568 |url= |pmc=3230933|display-authors=etal}}</ref>
'''CDKN2B-AS''', also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 [[exons]], spanning 126.3kb in the [[genome]], and its spliced product is a 3834bp [[RNA]]. It is located within the p15/[[CDKN2B]]-p16/[[P16 (gene)|CDKN2A]]-p14/[[p14arf|ARF]] gene cluster, in the [[antisense]] direction. [[Single-nucleotide polymorphism|Single nucleotide polymorphisms]] (SNPs) which alter the expression of CDKN2B-AS are associated with many diseases, including [[coronary artery disease]], [[diabetes]] and many [[cancers]].<ref name="pmid20386740">{{cite journal |vauthors=Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B |title=Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression |journal=PLoS Genet. |volume=6 |issue=4 |pages=e1000899 |year=2010 |pmid=20386740 |pmc=2851566 |doi=10.1371/journal.pgen.1000899 |url= |editor1-last=Gibson |editor1-first=Greg}}</ref> It binds to chromobox 7 (CBX7) within the [[polycomb repressive complex 1]] and to [[SUZ12]], a component of [[PRC2|polycomb repression complex 2]] and through these interactions is involved in [[Transcription (genetics)|transcriptional]] repression.<ref name="pmid20541999">{{cite journal |vauthors=Yap KL, Li S, Muñoz-Cabello AM |title=Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a |journal=Mol. Cell |volume=38 |issue=5 |pages=662–74 |date=June 2010 |pmid=20541999 |doi=10.1016/j.molcel.2010.03.021 |url= |pmc=2886305|display-authors=etal}}</ref><ref name="pmid21151178">{{cite journal |vauthors=Kotake Y, Nakagawa T, Kitagawa K |title=Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene |journal=Oncogene |volume= 30|issue= 16|pages= 1956–1962|date=December 2010 |pmid=21151178 |doi=10.1038/onc.2010.568 |url= |pmc=3230933|display-authors=etal}}</ref>


==See also==
==See also==
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*{{cite journal  |vauthors=Uno S, Zembutsu H, Hirasawa A |title=A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese |journal=Nat. Genet. |volume=42 |issue= 8 |pages= 707–10 |year= 2010 |pmid= 20601957 |doi= 10.1038/ng.612 |display-authors=etal}}
*{{cite journal  |vauthors=Uno S, Zembutsu H, Hirasawa A |title=A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese |journal=Nat. Genet. |volume=42 |issue= 8 |pages= 707–10 |year= 2010 |pmid= 20601957 |doi= 10.1038/ng.612 |display-authors=etal}}
*{{cite journal  |vauthors=Wrensch M, Jenkins RB, Chang JS |title=Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility |journal=Nat. Genet. |volume=41 |issue= 8 |pages= 905–8 |year= 2009 |pmid= 19578366 |doi= 10.1038/ng.408  |pmc=2923561 |display-authors=etal}}
*{{cite journal  |vauthors=Wrensch M, Jenkins RB, Chang JS |title=Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility |journal=Nat. Genet. |volume=41 |issue= 8 |pages= 905–8 |year= 2009 |pmid= 19578366 |doi= 10.1038/ng.408  |pmc=2923561 |display-authors=etal}}
*{{cite journal  |vauthors=Gretarsdottir S, Baas AF, Thorleifsson G |title=Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |journal=Nat. Genet. |volume=42 |issue= 8 |pages= 692–7 |year= 2010 |pmid= 20622881 |doi= 10.1038/ng.622 |display-authors=etal}}
*{{cite journal  |vauthors=Gretarsdottir S, Baas AF, Thorleifsson G |title=Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm |journal=Nat. Genet. |volume=42 |issue= 8 |pages= 692–7 |year= 2010 |pmid= 20622881 |doi= 10.1038/ng.622 |display-authors=etal|pmc=4157066 }}
*{{cite journal  |vauthors=Bilguvar K, Yasuno K, Niemelä M |title=Susceptibility loci for intracranial aneurysm in European and Japanese populations |journal=Nat. Genet. |volume=40 |issue= 12 |pages= 1472–7 |year= 2008 |pmid= 18997786 |doi= 10.1038/ng.240  |pmc=2682433 |display-authors=etal}}
*{{cite journal  |vauthors=Bilguvar K, Yasuno K, Niemelä M |title=Susceptibility loci for intracranial aneurysm in European and Japanese populations |journal=Nat. Genet. |volume=40 |issue= 12 |pages= 1472–7 |year= 2008 |pmid= 18997786 |doi= 10.1038/ng.240  |pmc=2682433 |display-authors=etal}}
*{{cite journal  |vauthors=Sato K, Nakagawa H, Tajima A |title=ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1 |journal=Oncol. Rep. |volume=24 |issue= 3 |pages= 701–7 |year= 2010 |pmid= 20664976 |doi=  10.3892/or_00000910|display-authors=etal}}
*{{cite journal  |vauthors=Sato K, Nakagawa H, Tajima A |title=ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1 |journal=Oncol. Rep. |volume=24 |issue= 3 |pages= 701–7 |year= 2010 |pmid= 20664976 |doi=  10.3892/or_00000910|display-authors=etal}}
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*{{cite journal  |vauthors=Kathiresan S, Voight BF |title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants |journal=Nat. Genet. |volume=41 |issue= 3 |pages= 334–41 |year= 2009 |pmid= 19198609 |doi= 10.1038/ng.327 |pmc=2681011|display-authors=etal}}
*{{cite journal  |vauthors=Kathiresan S, Voight BF |title=Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants |journal=Nat. Genet. |volume=41 |issue= 3 |pages= 334–41 |year= 2009 |pmid= 19198609 |doi= 10.1038/ng.327 |pmc=2681011|display-authors=etal}}
*{{cite journal  |vauthors=Bei JX, Li Y, Jia WH |title=A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci |journal=Nat. Genet. |volume=42 |issue= 7 |pages= 599–603 |year= 2010 |pmid= 20512145 |doi= 10.1038/ng.601 |display-authors=etal}}
*{{cite journal  |vauthors=Bei JX, Li Y, Jia WH |title=A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci |journal=Nat. Genet. |volume=42 |issue= 7 |pages= 599–603 |year= 2010 |pmid= 20512145 |doi= 10.1038/ng.601 |display-authors=etal}}
*{{cite journal  |vauthors=Turnbull C, Ahmed S, Morrison J |title=Genome-wide association study identifies five new breast cancer susceptibility loci |journal=Nat. Genet. |volume=42 |issue= 6 |pages= 504–7 |year= 2010 |pmid= 20453838 |doi= 10.1038/ng.586 |display-authors=etal}}
*{{cite journal  |vauthors=Turnbull C, Ahmed S, Morrison J |title=Genome-wide association study identifies five new breast cancer susceptibility loci |journal=Nat. Genet. |volume=42 |issue= 6 |pages= 504–7 |year= 2010 |pmid= 20453838 |doi= 10.1038/ng.586 |display-authors=etal|pmc=3632836 }}
*{{cite journal  |vauthors=Schaefer AS, Richter GM, Groessner-Schreiber B |title=Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis |journal=PLoS Genet. |volume=5 |issue= 2 |pages= e1000378 |year= 2009 |pmid= 19214202 |doi= 10.1371/journal.pgen.1000378  |editor1-last=Marchini  |editor1-first=Jonathan  |pmc=2632758 |display-authors=etal}}
*{{cite journal  |vauthors=Schaefer AS, Richter GM, Groessner-Schreiber B |title=Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis |journal=PLoS Genet. |volume=5 |issue= 2 |pages= e1000378 |year= 2009 |pmid= 19214202 |doi= 10.1371/journal.pgen.1000378  |editor1-last=Marchini  |editor1-first=Jonathan  |pmc=2632758 |display-authors=etal}}
{{refend}}
{{refend}}

Latest revision as of 07:45, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
CDKN2B antisense RNA 1 intronic convserved region
File:CDKN2B-AS secondary structure.jpg
Predicted secondary structure and sequence conservation of CDKN2B-AS
Identifiers
SymbolCDKN2B-AS
Alt. SymbolsANRIL
RfamRF01909
Other data
RNA typeGene;
Domain(s)Eukaryota;
GO0006342 0005515
SO0001463
PDB structuresPDBe

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with many diseases, including coronary artery disease, diabetes and many cancers.[1] It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.[2][3]

See also

References

  1. ↑ Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B (2010). Gibson G, ed. "Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression". PLoS Genet. 6 (4): e1000899. doi:10.1371/journal.pgen.1000899. PMC 2851566. PMID 20386740.
  2. ↑ Yap KL, Li S, Muñoz-Cabello AM, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Mol. Cell. 38 (5): 662–74. doi:10.1016/j.molcel.2010.03.021. PMC 2886305. PMID 20541999.
  3. ↑ Kotake Y, Nakagawa T, Kitagawa K, et al. (December 2010). "Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene". Oncogene. 30 (16): 1956–1962. doi:10.1038/onc.2010.568. PMC 3230933. PMID 21151178.

Further reading

External links

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