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'''Guanine deaminase''' also known as '''cypin''', '''guanase''', '''guanine aminase''', '''GAH''', and '''guanine aminohydrolase''' is an [[aminohydrolase]] enzyme which converts [[guanine]] to [[xanthine]].<ref>{{cite journal | vauthors = Hitchings GH, Falco EA | title = The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 30 | issue = 10 | pages = 294–7 | date = Oct 1944 | pmid = 16578130 | pmc = 1078714 | doi = 10.1073/pnas.30.10.294 }}</ref><ref name="pmid20285041">{{cite journal | vauthors = Kalckar HM | title = Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism | journal = J. Biol. Chem. | volume = 167 | issue = 2 | pages = 461–75 | year = 1947 | pmid = 20285041 | doi = | url = }}</ref><ref>{{cite journal | vauthors = Rabinowitz JC, Barker HA | title = Purine fermentation by Clostridium cylindrosporum. II. Purine transformations | journal = The Journal of Biological Chemistry | volume = 218 | issue = 1 | pages = 161–73 | date = Jan 1956 | pmid = 13278325 }}</ref> Cypin is a major [[cytosolic]] protein that interacts with [[PSD-95]]. It promotes localized microtubule assembly in neuronal [[dendrites]].<ref name="pmid10595517">{{cite journal | vauthors = Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS | title = Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting | journal = Neuron | volume = 24 | issue = 3 | pages = 659–72 | year = 1999 | pmid = 10595517 | doi = 10.1016/S0896-6273(00)81120-4| url = }}</ref>
'''Guanine deaminase''' also known as '''cypin''', '''guanase''', '''guanine aminase''', '''GAH''', and '''guanine aminohydrolase''' is an [[aminohydrolase]] enzyme which converts [[guanine]] to [[xanthine]].<ref>{{cite journal | vauthors = Hitchings GH, Falco EA | title = The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 30 | issue = 10 | pages = 294–7 | date = Oct 1944 | pmid = 16578130 | pmc = 1078714 | doi = 10.1073/pnas.30.10.294 }}</ref><ref name="pmid20285041">{{cite journal | vauthors = Kalckar HM | title = Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism | journal = J. Biol. Chem. | volume = 167 | issue = 2 | pages = 461–75 | year = 1947 | pmid = 20285041 | doi = | url = }}</ref><ref>{{cite journal | vauthors = Rabinowitz JC, Barker HA | title = Purine fermentation by Clostridium cylindrosporum. II. Purine transformations | journal = The Journal of Biological Chemistry | volume = 218 | issue = 1 | pages = 161–73 | date = Jan 1956 | pmid = 13278325 }}</ref> Cypin is a major [[cytosolic]] protein that interacts with [[PSD-95]]. It promotes localized microtubule assembly in neuronal [[dendrites]].<ref name="pmid10595517">{{cite journal | vauthors = Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS | title = Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting | journal = Neuron | volume = 24 | issue = 3 | pages = 659–72 | year = 1999 | pmid = 10595517 | doi = 10.1016/S0896-6273(00)81120-4| url = }}</ref>
[[File:Guanine-xanthine.png|300px|thumb|center|Xanthine synthesis from guanine]]
[[File:Guanine-xanthine.png|600px|thumb|center|Xanthine synthesis from guanine]]
Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[1][2][3] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[4]
↑Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. PMID20285041.
↑Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. PMID13278325.
↑Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID10595517.
