CAPN6: Difference between revisions
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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site | [[Calpain|Calpains]] are ubiquitous, well-conserved family of calcium-dependent, [[Cysteine protease|cysteine proteases]]. The calpain proteins are [[heterodimers]] consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in [[Neurodegeneration|neurodegenerative]] processes, as their activation can be triggered by [[calcium]] influx and [[oxidative stress]]. The protein encoded by this gene is highly expressed in the [[placenta]]. Its [[C-terminus|C-terminal]] region lacks any [[Homology (biology)|homology]] to the [[calmodulin]]-like domain of other calpains. The protein lacks a critical [[catalytic triad]] residue in its active site (cysteine nucleophile mutated to lysine) and thus is suggested to be proteolytically inactive. The protein may play a role in [[Neoplasm|tumor]] formation by inhibiting [[apoptosis]] and promoting [[angiogenesis]]. | ||
== References == | == References == | ||
Latest revision as of 11:28, 20 December 2018
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| External IDs | GeneCards: [1] | ||||||
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Calpain 6 is a protein in humans that is encoded by the CAPN6 gene. [1]
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks a critical catalytic triad residue in its active site (cysteine nucleophile mutated to lysine) and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
References
- ↑ "Entrez Gene: Calpain 6". Retrieved 2013-03-05.
 | This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |