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'''Cohesin subunit SA-2''' is a [[protein]] that in humans is encoded by the ''STAG2'' [[gene]].<ref name="pmid9305759">{{cite journal | vauthors = Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D | title = SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs | journal = Gene | volume = 195 | issue = 2 | pages = 151–9 | date = August 1997 | pmid = 9305759 | pmc = | doi = 10.1016/S0378-1119(97)00121-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAG2 stromal antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10735| accessdate = }}</ref> | '''Cohesin subunit SA-2''' is a [[protein]] that in humans is encoded by the ''STAG2'' [[gene]].<ref name="pmid9305759">{{cite journal | vauthors = Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D | title = SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs | journal = Gene | volume = 195 | issue = 2 | pages = 151–9 | date = August 1997 | pmid = 9305759 | pmc = | doi = 10.1016/S0378-1119(97)00121-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAG2 stromal antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10735| accessdate = }}</ref> | ||
== | == Function == | ||
STAG2 has been shown to [[Protein-protein interaction|interact]] with [[STAG1]].<ref name=pmid11076961>{{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = The Journal of Cell Biology | volume = 151 | issue = 4 | pages = 749–62 | date = November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749 }}</ref> | STAG2 is part of the [[Cohesin|cohesin complex]], which is a structure that holds the sister [[Chromatid|chromatids]] together after [[DNA replication]].<ref>{{Cite journal|last=Mehta|first=Gunjan D.|last2=Kumar|first2=Ravinder|last3=Srivastava|first3=Sanjeeva|last4=Ghosh|first4=Santanu Kumar|date=2013-08-02|title=Cohesin: Functions beyond sister chromatid cohesion|journal=FEBS Letters|language=en|volume=587|issue=15|pages=2299–2312|doi=10.1016/j.febslet.2013.06.035|pmid=23831059|issn=1873-3468}}</ref> STAG2 has been shown to [[Protein-protein interaction|interact]] with [[STAG1]].<ref name=pmid11076961>{{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = The Journal of Cell Biology | volume = 151 | issue = 4 | pages = 749–62 | date = November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749 }}</ref> | ||
== Role in Disease == | |||
Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. <ref>{{Cite web|url=http://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=STAG2|title=STAG2 Gene - COSMIC|last=Cosmic|website=cancer.sanger.ac.uk|access-date=2018-02-13}}</ref> This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.<ref>{{Cite journal|last=Kim|first=Jung-Sik|last2=He|first2=Xiaoyuan|last3=Orr|first3=Bernardo|last4=Wutz|first4=Gordana|last5=Hill|first5=Victoria|last6=Peters|first6=Jan-Michael|last7=Compton|first7=Duane A.|last8=Waldman|first8=Todd|date=2016-02-12|title=Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2|journal=PLOS Genetics|language=en|volume=12|issue=2|pages=e1005865|doi=10.1371/journal.pgen.1005865|pmid=26871722|pmc=4752446|issn=1553-7404}}</ref> | |||
== References == | == References == | ||
Latest revision as of 22:39, 5 September 2018
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Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.[1][2]
Function
STAG2 is part of the cohesin complex, which is a structure that holds the sister chromatids together after DNA replication.[3] STAG2 has been shown to interact with STAG1.[4]
Role in Disease
Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. [5] This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.[6]
References
- ↑ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
- ↑ "Entrez Gene: STAG2 stromal antigen 2".
- ↑ Mehta, Gunjan D.; Kumar, Ravinder; Srivastava, Sanjeeva; Ghosh, Santanu Kumar (2013-08-02). "Cohesin: Functions beyond sister chromatid cohesion". FEBS Letters. 587 (15): 2299–2312. doi:10.1016/j.febslet.2013.06.035. ISSN 1873-3468. PMID 23831059.
- ↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
- ↑ Cosmic. "STAG2 Gene - COSMIC". cancer.sanger.ac.uk. Retrieved 2018-02-13.
- ↑ Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo; Wutz, Gordana; Hill, Victoria; Peters, Jan-Michael; Compton, Duane A.; Waldman, Todd (2016-02-12). "Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2". PLOS Genetics. 12 (2): e1005865. doi:10.1371/journal.pgen.1005865. ISSN 1553-7404. PMC 4752446. PMID 26871722.
Further reading
- Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB (September 1993). "cDNA clones contain autonomous replication activity". Biochimica et Biophysica Acta. 1174 (3): 241–57. doi:10.1016/0167-4781(93)90193-h. PMID 7690594.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
- Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K (December 2001). "A potential role for human cohesin in mitotic spindle aster assembly". The Journal of Biological Chemistry. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
- Prieto I, Pezzi N, Buesa JM, Kremer L, Barthelemy I, Carreiro C, Roncal F, Martinez A, Gomez L, Fernandez R, Martinez-A C, Barbero JL (June 2002). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Reports. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMC 1084142. PMID 12034751.
- Lara-Pezzi E, Pezzi N, Prieto I, Barthelemy I, Carreiro C, Martínez A, Maldonado-Rodríguez A, López-Cabrera M, Barbero JL (February 2004). "Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3". The Journal of Biological Chemistry. 279 (8): 6553–9. doi:10.1074/jbc.M307663200. PMID 14660624.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM (March 2005). "Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2". PLoS Biology. 3 (3): e69. doi:10.1371/journal.pbio.0030069. PMC 1054881. PMID 15737063. open access publication – free to read
- McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K (March 2005). "Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells". PLoS Biology. 3 (3): e86. doi:10.1371/journal.pbio.0030086. PMC 1054882. PMID 15737064. open access publication – free to read
- Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". Journal of Cell Science. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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