Shroom family member 2: Difference between revisions
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| title = Entrez Gene: Shroom family member 2 | | title = Entrez Gene: Shroom family member 2 | ||
| url = | | url = https://www.ncbi.nlm.nih.gov/gene/357 | ||
| accessdate = 2017-11-05 | | accessdate = 2017-11-05 | ||
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Latest revision as of 10:11, 12 January 2019
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Shroom family member 2 is a protein that in humans is encoded by the SHROOM2 gene. [1]
Function
This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
References
- ↑ "Entrez Gene: Shroom family member 2". Retrieved 2017-11-05.
Further reading
- Farber MJ, Rizaldy R, Hildebrand JD (2011). "Shroom2 regulates contractility to control endothelial morphogenesis". Mol. Biol. Cell. 22 (6): 795–805. doi:10.1091/mbc.E10-06-0505. PMC 3057704. PMID 21248203.
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