Alpha 1-antitrypsin deficiency risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Alpha 1-antitrypsin deficiency}} | {{Alpha 1-antitrypsin deficiency}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{Mazia}} | ||
==Overview== | ==Overview== | ||
First degree relatives of patients with known AAT deficiency are at an increased risk for the condition.Smoking is risk factor for development of serious lung disease in patients with AAT deficiency.Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances. | [[First degree relative|First degree relatives]] of [[patients]] with known AAT deficiency are at an increased risk for the condition. [[Smoking]] is [[Risk factors|risk factor]] for [[development]] of serious [[lung disease]] in patients with AAT deficiency. Risk for [[lung disease]] also increases with [[Exposure assessment|exposure]] to dust, fumes, or other toxic substances. | ||
==Risk Factors== | ==Risk Factors== | ||
Risk factors associated with development of alpha 1-antitrypsin deficiency are as follows:<ref name="pmid28752442">{{cite journal |vauthors=Kalfopoulos M, Wetmore K, ElMallah MK |title=Pathophysiology of Alpha-1 Antitrypsin Lung Disease |journal=Methods Mol. Biol. |volume=1639 |issue= |pages=9–19 |year=2017 |pmid=28752442 |doi=10.1007/978-1-4939-7163-3_2 |url=}}</ref><ref name="pmid21960536">{{cite journal |vauthors=Stoller JK, Aboussouan LS |title=A review of α1-antitrypsin deficiency |journal=Am. J. Respir. Crit. Care Med. |volume=185 |issue=3 |pages=246–59 |year=2012 |pmid=21960536 |doi=10.1164/rccm.201108-1428CI |url=}}</ref> | [[Risk factors]] associated with development of alpha 1-antitrypsin deficiency are as follows:<ref name="pmid28752442">{{cite journal |vauthors=Kalfopoulos M, Wetmore K, ElMallah MK |title=Pathophysiology of Alpha-1 Antitrypsin Lung Disease |journal=Methods Mol. Biol. |volume=1639 |issue= |pages=9–19 |year=2017 |pmid=28752442 |doi=10.1007/978-1-4939-7163-3_2 |url=}}</ref><ref name="pmid21960536">{{cite journal |vauthors=Stoller JK, Aboussouan LS |title=A review of α1-antitrypsin deficiency |journal=Am. J. Respir. Crit. Care Med. |volume=185 |issue=3 |pages=246–59 |year=2012 |pmid=21960536 |doi=10.1164/rccm.201108-1428CI |url=}}</ref> | ||
*First degree relatives of patients with known AAT deficiency are at an increased risk | *[[First degree relative|First degree relatives]] of patients with known AAT deficiency are at an increased risk of inheriting the disorder. | ||
*Smoking is risk factor for development of serious lung disease in patients with AAT deficiency. | *[[Smoking]] is [[Risk factors|risk factor]] for development of [[Lung disease|serious lung disease]] in [[patients]] with AAT deficiency. | ||
*Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances. | *Risk for [[lung disease]] also increases with exposure to dust, fumes, or other toxic substances. | ||
==References== | ==References== | ||
Latest revision as of 16:43, 23 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
First degree relatives of patients with known AAT deficiency are at an increased risk for the condition. Smoking is risk factor for development of serious lung disease in patients with AAT deficiency. Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances.
Risk Factors
Risk factors associated with development of alpha 1-antitrypsin deficiency are as follows:[1][2]
- First degree relatives of patients with known AAT deficiency are at an increased risk of inheriting the disorder.
- Smoking is risk factor for development of serious lung disease in patients with AAT deficiency.
- Risk for lung disease also increases with exposure to dust, fumes, or other toxic substances.
References
- ↑ Kalfopoulos M, Wetmore K, ElMallah MK (2017). "Pathophysiology of Alpha-1 Antitrypsin Lung Disease". Methods Mol. Biol. 1639: 9–19. doi:10.1007/978-1-4939-7163-3_2. PMID 28752442.
- ↑ Stoller JK, Aboussouan LS (2012). "A review of α1-antitrypsin deficiency". Am. J. Respir. Crit. Care Med. 185 (3): 246–59. doi:10.1164/rccm.201108-1428CI. PMID 21960536.