Polycythemia vera history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Polycythemia vera}} | {{Polycythemia vera}} | ||
{{CMG}}{{AE}}{{MJK}} | {{CMG}} {{AE}} {{IO}} {{MJK}}; {{shyam}} | ||
==Overview== | ==Overview== | ||
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]]. | People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]] especially after exposure to warm water, loss of concentration and [[night sweats]] and neurological symptoms. | ||
==History | ==History and Symptoms== | ||
===History=== | |||
Patients with polycythemia vera may have a positive history of:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref> | |||
*[[Pruritus]] | |||
*[[Fatigue]] | |||
*[[Headache]] | *[[Headache]] | ||
*[[ | *[[Early satiety]] | ||
===Common Symptoms=== | |||
: | Common symptoms of polycythemia vera include:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref><ref name="pmid19468728">{{cite journal |vauthors=Cario H, McMullin MF, Pahl HL |title=Clinical and hematological presentation of children and adolescents with polycythemia vera |journal=Ann. Hematol. |volume=88 |issue=8 |pages=713–9 |date=August 2009 |pmid=19468728 |pmc=4135082 |doi=10.1007/s00277-009-0758-y |url=}}</ref><ref name="pmid20597963">{{cite journal |vauthors=Saini KS, Patnaik MM, Tefferi A |title=Polycythemia vera-associated pruritus and its management |journal=Eur. J. Clin. Invest. |volume=40 |issue=9 |pages=828–34 |date=September 2010 |pmid=20597963 |doi=10.1111/j.1365-2362.2010.02334.x |url=}}</ref> | ||
*[[Fatigue]] | *[[Fatigue]] | ||
*[[ | *[[Headache]] | ||
*[[ | *[[Pruritus]] | ||
**Especially after exposure to warm water | |||
**May be related to [[serotonin]] release by [[Platelet|platelets]] as well as elevated [[histamine]] levels | |||
*Abdominal pain | |||
*Loss of concentration | |||
*[[Night sweats]] | |||
*Sexual problems | |||
*[[ | *[[Insomnia]] | ||
*[[ | *Decreased mood | ||
*[[Numbness]] | |||
*[[Early satiety]] | |||
*[[Dizziness]] | |||
*[[Cough]] | |||
*[[Erythromelalgia]] | *[[Erythromelalgia]] | ||
*[[ | *[[Weakness]] | ||
:* | |||
===Less Common Symptoms=== | |||
Less common symptoms of polycythemia vera include:<ref name="pmid26324368">{{cite journal |vauthors=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R |title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F |journal=J. Clin. Oncol. |volume=33 |issue=33 |pages=3953–60 |date=November 2015 |pmid=26324368 |pmc=4979103 |doi=10.1200/JCO.2015.61.6474 |url=}}</ref> | |||
*[[Fever]] | |||
*Weight loss | |||
*Sweating | |||
*Visual disturbances | |||
*[[Parasthesias|Paresthesia]] | |||
*[[Dyspnea]] | |||
*Bone pains | |||
==References== | ==References== | ||
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{{Hematology}} | {{Hematology}} | ||
{{Hematological malignancy histology}} | {{Hematological malignancy histology}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Mohamad Alkateb, MBBCh [3]; Shyam Patel [4]
Overview
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis especially after exposure to warm water, loss of concentration and night sweats and neurological symptoms.
History and Symptoms
History
Patients with polycythemia vera may have a positive history of:[1]
Common Symptoms
Common symptoms of polycythemia vera include:[1][2][3]
- Fatigue
- Headache
- Pruritus
- Abdominal pain
- Loss of concentration
- Night sweats
- Sexual problems
- Insomnia
- Decreased mood
- Numbness
- Early satiety
- Dizziness
- Cough
- Erythromelalgia
- Weakness
Less Common Symptoms
Less common symptoms of polycythemia vera include:[4]
- Fever
- Weight loss
- Sweating
- Visual disturbances
- Paresthesia
- Dyspnea
- Bone pains
References
- ↑ 1.0 1.1 Tefferi, A. (2002). "Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus". Blood. 99 (7): 2627–2627. doi:10.1182/blood.V99.7.2627. ISSN 0006-4971.
- ↑ Cario H, McMullin MF, Pahl HL (August 2009). "Clinical and hematological presentation of children and adolescents with polycythemia vera". Ann. Hematol. 88 (8): 713–9. doi:10.1007/s00277-009-0758-y. PMC 4135082. PMID 19468728.
- ↑ Saini KS, Patnaik MM, Tefferi A (September 2010). "Polycythemia vera-associated pruritus and its management". Eur. J. Clin. Invest. 40 (9): 828–34. doi:10.1111/j.1365-2362.2010.02334.x. PMID 20597963.
- ↑ Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.