Gallbladder cancer natural history: Difference between revisions
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==Overview== | ==Overview== | ||
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor. | Depending on the extent of the [[tumor]] at the time of diagnosis, the [[prognosis]] may vary. However, the [[prognosis]] is generally regarded as poor. | ||
==Natural History | == Natural History, Complications, and Prognosis == | ||
== | ===Natural History=== | ||
* Most [[Tumor|tumors]] are [[adenocarcinoma|adenocarcinomas]], with a small percent being [[squamous cell]] carcinomas. | |||
The survival rate depends on the extent of cancer at the time of diagnosis with gallbladder cancer and early detection is the key for good prognosis | * The [[cancer]] commonly spreads to the [[liver]], [[pancreas]], [[stomach]] and [[duodenum]]. | ||
* Gallbladder cancer has an overall 5-year survival rate less than 5%. | |||
=== Complications === | |||
* Abdominal pain and cramping | |||
* [[Bloating]] | |||
* [[Confusion]] | |||
* [[Pancreatitis]] | |||
* Acute [[Cholangitis]] | |||
* [[Fever]] | |||
===Prognosis=== | |||
* The survival rate depends on the extent of [[cancer]] at the time of diagnosis with [[gallbladder cancer]] and early detection is the key for good [[prognosis]] | |||
* [[Gallbladder cancer]] has an overall 5-year survival rate less than 5%. | |||
* Advances in perioperative care has markedly improved outcomes.<ref name="pmid18488776">{{cite journal |vauthors=Lai CH, Lau WY |title=Gallbladder cancer--a comprehensive review |journal=Surgeon |volume=6 |issue=2 |pages=101–10 |year=2008 |pmid=18488776 |doi= |url=}}</ref> | * Advances in perioperative care has markedly improved outcomes.<ref name="pmid18488776">{{cite journal |vauthors=Lai CH, Lau WY |title=Gallbladder cancer--a comprehensive review |journal=Surgeon |volume=6 |issue=2 |pages=101–10 |year=2008 |pmid=18488776 |doi= |url=}}</ref> | ||
* Recent Improvements in surgical techniques have resulted in a decline of both morbidity and mortality of the gallbladder cancer prognosis. | * Recent Improvements in surgical techniques have resulted in a decline of both [[morbidity]] and [[mortality]] of the [[gallbladder cancer]] prognosis. | ||
* 5-year survival rate is | * 5-year survival rate is seen in patients who undergo R0 curative resection.<ref name="pmid21547707">{{cite journal |vauthors=Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, Sakabe R, Kobayashi H, Sueda T |title=Prognostic factors of patients with advanced gallbladder carcinoma following aggressive surgical resection |journal=J. Gastrointest. Surg. |volume=15 |issue=6 |pages=1007–16 |year=2011 |pmid=21547707 |doi=10.1007/s11605-011-1479-9 |url=}}</ref><ref name="pmid23522952">{{cite journal |vauthors=D'Hondt M, Lapointe R, Benamira Z, Pottel H, Plasse M, Letourneau R, Roy A, Dagenais M, Vandenbroucke-Menu F |title=Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience |journal=Eur J Surg Oncol |volume=39 |issue=6 |pages=548–53 |year=2013 |pmid=23522952 |doi=10.1016/j.ejso.2013.02.010 |url=}}</ref> | ||
* Only 2–8 months survival rate has been noticed by French Surgical Association with T3/T4 tumours. | * Only 2–8 months survival rate has been noticed by French Surgical Association with T3/T4 tumours. | ||
* | * Identified independent predictors such as age, tumour grade,T1 subtype, tumour histology, [[radiation]], and surgery type. | ||
* The prognosis is not good for most [[gallbladder cancer]] patients if the cancer is detected in its late stages. <ref name="pmid26421012">{{cite journal |vauthors=Kanthan R, Senger JL, Ahmed S, Kanthan SC |title=Gallbladder Cancer in the 21st Century |journal=J Oncol |volume=2015 |issue= |pages=967472 |year=2015 |pmid=26421012 |pmc=4569807 |doi=10.1155/2015/967472 |url=}}</ref> | |||
* The prognosis is not good for most gallbladder cancer patients if the cancer is detected in its late stages | * Among all the histological types [[papillary]] [[carcinomas]] are having one of the best prognosis.<ref name="pmid1516000">{{cite journal |vauthors=Henson DE, Albores-Saavedra J, Corle D |title=Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates |journal=Cancer |volume=70 |issue=6 |pages=1493–7 |year=1992 |pmid=1516000 |doi= |url=}}</ref> | ||
* Among all the histological types | * Intramural [[invasion]] is seen in [[adenocarcinomas]] and are associated with worst prognosis, whether or not the [[tumor]] can be removed by [[surgery|surgery.]]<ref name="pmid264210122">{{cite journal |vauthors=Kanthan R, Senger JL, Ahmed S, Kanthan SC |title=Gallbladder Cancer in the 21st Century |journal=J Oncol |volume=2015 |issue= |pages=967472 |year=2015 |pmid=26421012 |pmc=4569807 |doi=10.1155/2015/967472 |url=}}</ref> | ||
* Intramural | *The [[prognosis]] of the cancer also can depends on the following factors: | ||
**Stage of the [[cancer]] | |||
* | **Size of the [[tumor]], whether the [[cancer]] has spread outside the [[gallbladder]] | ||
* | **Patient’s general health | ||
* | |||
==References== | ==References== | ||
Latest revision as of 14:16, 9 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.
Natural History, Complications, and Prognosis
Natural History
- Most tumors are adenocarcinomas, with a small percent being squamous cell carcinomas.
Complications
- Abdominal pain and cramping
- Bloating
- Confusion
- Pancreatitis
- Acute Cholangitis
- Fever
Prognosis
- The survival rate depends on the extent of cancer at the time of diagnosis with gallbladder cancer and early detection is the key for good prognosis
- Gallbladder cancer has an overall 5-year survival rate less than 5%.
- Advances in perioperative care has markedly improved outcomes.[1]
- Recent Improvements in surgical techniques have resulted in a decline of both morbidity and mortality of the gallbladder cancer prognosis.
- 5-year survival rate is seen in patients who undergo R0 curative resection.[2][3]
- Only 2–8 months survival rate has been noticed by French Surgical Association with T3/T4 tumours.
- Identified independent predictors such as age, tumour grade,T1 subtype, tumour histology, radiation, and surgery type.
- The prognosis is not good for most gallbladder cancer patients if the cancer is detected in its late stages. [4]
- Among all the histological types papillary carcinomas are having one of the best prognosis.[5]
- Intramural invasion is seen in adenocarcinomas and are associated with worst prognosis, whether or not the tumor can be removed by surgery.[6]
- The prognosis of the cancer also can depends on the following factors:
- Stage of the cancer
- Size of the tumor, whether the cancer has spread outside the gallbladder
- Patient’s general health
References
- ↑ Lai CH, Lau WY (2008). "Gallbladder cancer--a comprehensive review". Surgeon. 6 (2): 101–10. PMID 18488776.
- ↑ Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, Sakabe R, Kobayashi H, Sueda T (2011). "Prognostic factors of patients with advanced gallbladder carcinoma following aggressive surgical resection". J. Gastrointest. Surg. 15 (6): 1007–16. doi:10.1007/s11605-011-1479-9. PMID 21547707.
- ↑ D'Hondt M, Lapointe R, Benamira Z, Pottel H, Plasse M, Letourneau R, Roy A, Dagenais M, Vandenbroucke-Menu F (2013). "Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience". Eur J Surg Oncol. 39 (6): 548–53. doi:10.1016/j.ejso.2013.02.010. PMID 23522952.
- ↑ Kanthan R, Senger JL, Ahmed S, Kanthan SC (2015). "Gallbladder Cancer in the 21st Century". J Oncol. 2015: 967472. doi:10.1155/2015/967472. PMC 4569807. PMID 26421012.
- ↑ Henson DE, Albores-Saavedra J, Corle D (1992). "Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates". Cancer. 70 (6): 1493–7. PMID 1516000.
- ↑ Kanthan R, Senger JL, Ahmed S, Kanthan SC (2015). "Gallbladder Cancer in the 21st Century". J Oncol. 2015: 967472. doi:10.1155/2015/967472. PMC 4569807. PMID 26421012.