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| ==Pathophysiology of ILD== | | ==Images ILD== |
| {{Family tree/start}}
| | <gallery widths=200px> |
| {{Family tree| | | | | | | | | | | | | | | | | | | | | | | T01 | | | | | | | | | | | | T01=Tissue injury in lungs}}
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| {{Family tree| | | | | | | | | | | | | | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | | | | }}
| | F2.large.jpg | Cellular Players and Molecules in IPF <br> [http://err.ersjournals.com/content/24/135/102.full<font size="-2">''Adapted from European Respiratory Review''</font>] |
| {{Family tree| | | | | | | | | | | | | | | | | S01 | | | | | | | | | | S02 | | | | | | | S01=Epitehelial injury|S02=Vascular injury}}
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| {{Family tree| | | | | | | | | | | | | | | | | |!| | | | | | | | | | | |!| | | | | | | | }}
| | </gallery> |
| {{Family tree| | | | | | | | R01 | | | | | | | |!| | | | | | | | | | | R02 | | | | | | | R01=Mast cells in lungs|R02= LPA6, LPA2, and LPA4 receptors }}
| | <gallery widths=200px> |
| {{Family tree| | | | | | |,|-|^|-|.| | | | | | |!| | | | | | | | | |,|-|^|-|.| | | | | | }}
| | |
| {{Family tree| | Q01 | | Q06 | | Q03 | | | | | Q02 | | | | | | | | Q04 | | Q05 | | | | | Q01=Decreased sFRP-1 (secreted frizzled-related protein 1) in fibroblasts|Q02= Insulin-like growth factor (IGF) signalling|Q03=Transforming growth factor (TGF)-β|Q04= Reduced expression of angiogenic factors,<br>vascular endothelial growth factor (VEGF)|Q05=Elevation of angiostatic factors,<br>pigment epithelium-derived factor|Q06=Secretes tryptase}}
| | 1-s2.0-S0272523112000044-gr6.jpg | Flow Chart for Lung Fibrosis Evaluation in ILD <br> [http://http://www.sciencedirect.com/science/article/pii/S0272523112000044/ <font size="-2">''Adapted from Clinics in Chest Medicine''</font>] |
| {{Family tree| | |!| | | |!| | | |!| | | |,|-|-|^|-|-|.| | | | | | |`|-|v|-|'| | | | | | }}
| | |
| {{Family tree| | P01 | | P02 | | P05 | | P04 | | | | P03 |.| | | | | | | | P06 | | | | | P01=Wnt/β-catenin signalling pathway|P02=PAR-2/protein kinase (PK)C-α/Raf-1/p44/42 signaling pathway|P03=IGF-binding protein 3 (IGFBP-3)|P04=IGF-binding protein 5 (IGFBP-5)|P05=Upregulation of Egr-1 (early growth response protein 1)|P06=Loss of endothelial barrier function }}
| | </gallery> |
| {{Family tree| |!| |!| | |!| | | |!| | | |!| | | | | |!| |!| | | | | | |!| | | | | | | | }}
| | |
| {{Family tree| O01 |!| | |!| | | |`|-|-|-|^|.| | | | |!| O02 | | | | | |!| | | | | | | | O01=Dysregulation of repair in lung tissue|O02=Regulates transforming growth factor (TGF)-β }}
| | ==Widget== |
| {{Family tree| | | |!| | |!| | | | | | | | |!| | | | |!|,|'| | | | | | |!| | | | | | | | }}
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| {{Family tree| | | |!| | |!| | | | | | | | |!| | | | A02 | | | | | | | |!| | | | | | | | A01=|A02=Induction of syndecan-2 (SDC2)}}
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| {{Family tree| | | |!| | |!| | | | | | | | |!| | | | |!| | | | | | | | |!| | | | | | | | }}
| | <div class="nomobile"> |
| {{Family tree| | | |!| | |`|-|-|-|-|-|-|-|.|!|,|-|-|-|'| | | | | | | | |!| | | | | | | | }}
| | <div style="position:right; width:50%; float:right; background-color:#d0d0d0; border-radius: 10px;"><span style="position:right; float:right; width: 100%;"><center>'''Tweets by NEJM!'''<hr>{{#Widget:NEJM}}</center> |
| {{Family tree| | | |`|-|-|-|-|-|-|-|-|-|-| B01 | | | | | | | | | | | | |!| | | | | | | | B01=Activation,proliferation, and migration of fibroblast to the site of injury}}
| | </span></div> |
| {{Family tree| | | | | | | | | | | | | | | |!| | | | | | | | | | | | | |!| | | | | | | | }}
| | </div> |
| {{Family tree| | | | | | | | | | | | | | | C01 | | | | | | | | | | | | |!| | | | | | | | C01=Fibroblasts}}
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| {{Family tree| | | | | | | | | | | | |,|-|-|+|-|-|.| | | | | | | | | | |!| | | | | | | | }}
| | <br style="clear:right" /> |
| {{Family tree| | | | | | | | | | | | D01 | |!| | D02 | | | | | | | | | |!| | | | | | | | D01=Altered PTEN (phosphatase and tensin homologue)/Akt axis|D02=Acquire contractile stress fibres}}
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| {{Family tree| | | | | | | | | | | | |!| | |!| | |!| | | | | | | | | | |!| | | | | | | | }}
| |
| {{Family tree| | | | | | | | | | | | G01 | |!| | G02 | | G03 | | | | | |!| | | | | | | | G01= Inactivates Fox (forkhead box) O3a|G02=Protomyofibroblast,composed of cytoplasmic actins|G03=Pleural mesothelial cells (PMCs)}}
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| {{Family tree| | | | | | | | | | | | |!| | |!| | |!| | | |!| | | | | | |!| | | | | | | | }}
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| {{Family tree| | | | | | | | | | | | H01 | |!| | H02 | | H03 | | | | | |!| | | | | | | | H01= Downregulation of cav-1 and Fas expression|H02=De novo expression of α-SMA|H03=TGF-β1-dependent mesothelial–mesenchymal transition}}
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| {{Family tree| | | | | | | | | | | | |!| | |!| | | |!| |!| | | | | | | |!| | | | | | | | }}
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| {{Family tree| | | | | | | | | | | | I01 | |!| | | | I02 | | | | | | | |!| | | | | | | | I01=Fibroblast resistant to apoptosis|I02=Myofibroblasts}}
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| {{Family tree| | | | | | | | | | | | | | | |!| | | |!| |!| | | | | | | |!| | | | | | | | }}
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| {{Family tree| | | | | | | | | | | | | | | |!| | | |!| |)|-|-|-|-|.| | |!| | | | | | | | }}
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| {{Family tree| | | | | | | | | | | | | | | |!| | | |!| J02 | | | J03 | |!| | | | | | | | J02=Different ranges of contractions mediated by RhoA/Rho-associated kinase|J03=Changes in intracellular calcium concentrations}}
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| {{Family tree| | | | | | | | | | | | | | | |!| | | |!| | |`|-|v|-|'| | |!| | | | | | | | }}
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| {{Family tree| | | | | | | | K01 | | | | | |!| |,|-|'| | | | K02 | | | |!| | | | | K03 | K01=Recruitement of fibrocytes in lungs|K02=Lock step mechanism of cyclic and contractile events|K03=T-helper cell type 2 on site of injury}}
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| {{Family tree| | | | | | | | |!| | | | | | |!| |!| | | | | | |!| | | | |!| | | | | |!| | }} | |
| {{Family tree| | | | | | | | L01 | | | | | | L02 | | | | | | L03 | | | |!| | | | | L04 | |L01=Upregulation of C-X-C chemokine receptor type 4 (CXCR4)<br>on fibrocytes and its ligand<br>CXCL12 (stromal cell-derived factor 1)|L02=Excess ECM production|L03=Exerting traction force|L04=Interleukin-13}}
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| {{Family tree| | | | | | | | |!| | | | | | | |!|,|-|-|-|-|-|-|'| | | | |!| | | | | |!| | }}
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| {{Family tree| | | | | | | | M01 | | | | | | M02 | | | | | | | | | | | |!| | | | | M03 | |M01=Migration of fibrocytes to the site of injury|M02=Tissue remodelling|M03=Alternate pathway activation of macrophages}}
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| {{Family tree| | | | | | | | |!| | | | | | | |!| | | | | | | | | | | | |!| | | | | |!| | }}
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| {{Family tree| | | | | | | | |`|-|-|-|-|-|-|.|!|,|-|-|-|-|-|-|-|-|-|-|-|'| | | | | |!| | }}
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| {{Family tree| | | | | | | | | | | | | | | | N01 |-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|-|'| N01=Lung Fibrosis}}
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| {{Family tree/end}}
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| ==References== | | ==References== |
| <references />
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