Respiratory failure causes: Difference between revisions

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{{CMG}}; {{AE}} {{MKA}}  
{{CMG}}; {{AE}} {{MKA}}  
==Overview==
==Overview==
Common causes of respiratory failure include [[pneumonia]], [[pulmonary edema]], [[pulmonary embolism]], [[acute respiratory distress syndrome]], [[atelectasis]], [[asthma]], [[COPD]], [[neuromuscular]] and [[chest wall]] disorders, inadequate post-operative [[analgesia]], [[smoking]], [[obesity]] and [[shock]].  
Common causes of respiratory failure include [[pneumonia]], [[pulmonary edema]], [[pulmonary embolism]], [[acute respiratory distress syndrome]], [[atelectasis]], [[asthma]], [[COPD]], [[neuromuscular]] and [[chest wall]] disorders, inadequate post-operative [[analgesia]], [[smoking]], [[obesity]] and [[shock]]. Life-threatening causes of respiratory failure include [[chronic obstructive pulmonary disease]], acute on chronic respiratory failure, [[pulmonary]] infection, [[pulmonary embolism]], [[heart failure]], [[cardiac arrhythmia]] and [[lung cancer]].
 
==Causes==
==Causes==
===Life-threatening Causes===
===Life-threatening causes===
*Life-threatening causes of respiratory failure include [[chronic obstructive pulmonary disease]], acute on chronic respiratory failure, [[pulmonary]] infection, [[pulmonary embolism]], [[heart failure]], [[cardiac arrhythmia]] and [[lung cancer]].<ref name="pmid9151520">{{cite journal |vauthors=Zielinski J, MacNee W, Wedzicha J, Ambrosino N, Braghiroli A, Dolensky J, Howard P, Gorzelak K, Lahdensuo A, Strom K, Tobiasz M, Weitzenblum E |title=Causes of death in patients with COPD and chronic respiratory failure |journal=Monaldi Arch Chest Dis |volume=52 |issue=1 |pages=43–7 |date=February 1997 |pmid=9151520 |doi= |url=}}</ref>
*Life-threatening causes of respiratory failure include [[chronic obstructive pulmonary disease]], acute on chronic respiratory failure, [[pulmonary]] infection, [[pulmonary embolism]], [[heart failure]], [[cardiac arrhythmia]] and [[lung cancer]].<ref name="pmid9151520">{{cite journal |vauthors=Zielinski J, MacNee W, Wedzicha J, Ambrosino N, Braghiroli A, Dolensky J, Howard P, Gorzelak K, Lahdensuo A, Strom K, Tobiasz M, Weitzenblum E |title=Causes of death in patients with COPD and chronic respiratory failure |journal=Monaldi Arch Chest Dis |volume=52 |issue=1 |pages=43–7 |date=February 1997 |pmid=9151520 |doi= |url=}}</ref>


Causes of respiratory failure include:<ref name="Source: National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services.urlRespiratory Failure | National Heart, Lung, and Blood Institute (NHLBI)">{{cite web |url=https://www.nhlbi.nih.gov/health-topics/respiratory-failure |title=Respiratory Failure &#124; National Heart, Lung, and Blood Institute (NHLBI) |format= |work= |accessdate=}}</ref>
===Causes of respiratory failure based on classification of disease===
Causes of respiratory failure based on classification of disease include:<ref name="Source: National Heart, Lung, and Blood Institute; National Institutes of Health; U.S. Department of Health and Human Services.urlRespiratory Failure | National Heart, Lung, and Blood Institute (NHLBI)">{{cite web |url=https://www.nhlbi.nih.gov/health-topics/respiratory-failure |title=Respiratory Failure &#124; National Heart, Lung, and Blood Institute (NHLBI) |format= |work= |accessdate=}}</ref>


*Type I respiratory failure:
*'''Type I respiratory failure:'''
**[[Pneumonia]]
**[[Pneumonia]]
**[[Cardiogenic pulmonary edema]]
**[[Cardiogenic pulmonary edema]]
Line 23: Line 25:
**[[Pulmonary fibrosis]]
**[[Pulmonary fibrosis]]


*Type II respiratory failure:
*'''Type II respiratory failure:'''
**Central [[hypoventilation]]
**Central [[hypoventilation]]
**[[Asthma]]
**[[Asthma]]
Line 35: Line 37:
**[[Obesity hypoventilation syndrome]]
**[[Obesity hypoventilation syndrome]]


*Type III respiratory failure:
*'''Type III respiratory failure:'''
**Inadequate post-operative [[analgesia]]
**Inadequate post-operative [[analgesia]]
***Upper [[abdominal]] [[incision]]
***Upper [[abdominal]] [[incision]]
Line 43: Line 45:
**Excessive airway secretions
**Excessive airway secretions


*Type IV respiratory failure:
*'''Type IV respiratory failure:'''
**[[Cardiogenic shock]]
**[[Cardiogenic shock]]
**[[Septic shock]]
**[[Septic shock]]
Line 305: Line 307:


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
[[chronic obstructive pulmonary disease]]
{{columns-list|
acute on chronic respiratory failure  
*[[3-Quinuclidinyl benzilate]]
[[pulmonary]] infection
*Acute lung syndrome
[[pulmonary embolism]]  
*Acute on chronic respiratory failure  
[[heart failure]]
*[[Abrin]]
[[cardiac arrhythmia]]  
*[[Acetylsalicylic acid]]
[[lung cancer]]
*[[Achondrogenesis]]
[[Pneumonia]]
*[[Acute lung injury]]
[[Cardiogenic pulmonary edema]]
*[[Acute motor axonal neuropathy]]
Non-cardiogenic [[pulmonary edema]]
*[[Acute Porphyria]]
[[Acute lung injury]]
*[[Acute respiratory distress syndrome|Acute respiratory distress syndrome (ARDS)]]
[[Acute respiratory distress syndrome|Acute respiratory distress syndrome (ARDS)]]
*[[Alcohol]]
[[Pulmonary embolism]]
*[[Aldicarb]]
[[Atelectasis]]
*[[Alpha 1-antitrypsin deficiency]]
[[Pulmonary fibrosis]]
*[[Alpha-amanitin]]
Central [[hypoventilation]]
*[[Amyotrophic Lateral Sclerosis]]
[[Asthma]]
*[[Anaphylaxis]]
[[Chronic obstructive pulmonary disease]]
*[[Angioedema]]
[[Myopathies]]
*[[Antiphospholipid Antibody Syndrome]]
[[Neuropathies]]
*[[Asbestosis]]
[[Kyphoscoliosis]]
*[[Ascites]]
[[Myasthenia gravis]]  
*[[Aspiration]]
Inadequate post-operative [[analgesia]]
*[[Asthma]]
Upper [[abdominal]] [[incision]]
*[[Atelectasis]]
[[Obesity]]
*[[Atelosteogenesis, type II]]
[[Ascites]]
*[[Atrial septal defect (ostium primum)]]
Pre-operative [[tobacco smoking]]
*[[Azacitidine]]
Excessive airway secretions
*[[Babesiosis]]
[[Cardiogenic shock]]
*[[Barium nitrate]]
[[Septic shock]]
*[[Becker's muscular dystrophy]]
[[Hypovolemic shock]]
*[[Bland-White-Garland Syndrome]]
[[Azacitidine]]
*[[Blood transfusion]]
[[Codeine]]
*[[Botulism]]
[[Clozapine]]
*[[Bronchial asthma]]
[[Fentanyl]]
*[[Bronchiectasis]]
[[Gamma-Hydroxybutyric acid]]
*[[Bronchiolitis obliterans]]
[[Heroin]]
*[[Bronchiolitis]]
[[Ketamine]]
*[[Bronchogenic carcinoma]]
[[Lidocaine]]
*[[Bronchopulmonary dysplasia]]
[[Labetalol]]
*[[Bufotenin]]
[[Lorazepam]]
*[[Bungarotoxin]]
[[Morphine]]
*Central [[hypoventilation]]
[[Nitrazepam]]
*Coal worker pneumoconiosis
[[Opiate]]
*[[Carbon monoxide poisoning]]
[[Oxymorphone]]
*[[Cardiac arrhythmia]]
[[Procainamide (patient information)]]
*[[Cardiogenic pulmonary edema]]
[[Sodium thiopental]]
*[[Cardiogenic shock]]
[[Triazolam]]
*[[Carnitine palmitoyltransferase II deficiency]]
[[Zopiclone]]
*[[Ceritinib]]
[[Atrial septal defect (ostium primum)]]
*[[Cholesterol Emboli Syndrome]]
[[Ebstein anomaly]]
*[[Chronic obstructive pulmonary disease]]
[[Eisenmenger syndrome]]
*[[Clitocybe dealbata]]
[[Fallot tetralogy]]
*[[Clozapine]]
[[Pulmonary valve stenosis]]
*[[Cocaine]]
[[Transposition of great arteries]]
*[[Codeine]]
[[Tricuspid valve stenosis]]
*[[Colchicine]]
[[Ventricular septal defect]]
*[[Cone snail]]
[[Heart failure]]
*[[Congenital Central Hypoventilation Syndrome]]
[[Cardiac arrhythmia]]
*[[Congenital diaphragmatic hernia]]
[[Shock]]  
*[[Crimean-Congo hemorrhagic fever]]
[[3-Quinuclidinyl benzilate]]
*[[Crizotinib]]
[[Abrin]]
*[[Cyclophosphamide]]
[[Aldicarb]]
*[[Cystic adenomatoid malformation of lung]]
[[Alpha-amanitin]]
*[[Cystic fibrosis]]
[[Barium nitrate]]
*[[Cytisine]]
[[Bungarotoxin]]
*[[Desmopressin]]
[[Carbon monoxide poisoning]]
*[[Devic's disease]]
[[Ceritinib]]
*[[Dicofol]]
[[Cocaine]]
*[[Dornase Alfa]]
[[Cone snail]]
*[[Duchenne's Muscular Dystrophy]]
[[Furfural]]
*Excessive airway secretions
[[Snakebites]]
*[[Ebstein anomaly]]
[[Atrial septal defect (ostium primum)]]
*[[Eisenmenger syndrome]]
[[Bland-White-Garland Syndrome]]
*[[Emphysema]]
[[Congenital Central Hypoventilation Syndrome]]
*[[Eosinophilic pneumonia]]
[[Congenital diaphragmatic hernia]]
*[[EVAR]]
[[Fallot tetralogy]]
*[[Fallot tetralogy]]
[[Fetal circulation, persistent]]
*[[Familial dysautonomia]]
[[Respiratory distress syndrome (neonatal)]]
*[[Fat embolism]]
[[Codeine]]
*[[Fentanyl]]
[[Clozapine]]
*[[Fetal circulation, persistent]]
[[Crizotinib]]
*[[Fibrosing alveolitis]]
[[Cyclophosphamide]]
*[[Flail chest]]
[[Desmopressin]]
*[[Foreign body]]
[[Dornase Alfa]]
*[[Furfural]]
[[Fentanyl]]
*[[galsulfase]]
[[Gamma-Hydroxybutyric acid]]
*[[Gamma-Hydroxybutyric acid]]
[[galsulfase]],
*[[Guillain-Barre syndrome]]
[[Heroin]],
*[[Hamman-Rich Syndrome]]
[[Idursulfase]],
*[[Hantavirus Pulmonary Syndrome]]
[[interferon alfacon-1]],
*[[Heart failure]]
[[Ixabepilone]],
*[[Heartworm]]
[[Ketamine]],
*[[Hepatic failure]]
[[Lidocaine]],
*[[Hepatopulmonary syndrome]]
[[Labetalol]],
*[[Hereditary haemorrhagic telangiectasia]]
[[Lorazepam]],
*[[Heroin]]
[[Morphine]],
*[[Hypovolemic shock]]
[[Nitrazepam]],
*Inadequate post-operative [[analgesia]]
[[Opiate]],  
*[[Idursulfase]]
[[Oxymorphone]],
*[[interferon alfacon-1]]
[[Pegylated interferon alfa-2b]], [[Pramipexole]], [[Procainamide (patient information)]], [[Rasburicase]], [[Sodium thiopental]], [[Tretinoin]], [[Triazolam]], [[Vincristine sulfate liposome]],  [[Zopiclone]]
*[[Interstitial fibrosis]]
[[Asbestosis]],
*[[Ixabepilone]]
Coal worker pneumoconiosis,
*[[Ketamine]]
[[Smoke inhalation]],
*[[Kyphoscoliosis]]
Sulfur dioxide
*[[Labetalol]]
[[Hepatic failure]],
*[[Laryngo-/Bronchospasm]]
[[Hepatopulmonary syndrome]]
*[[Legionella pneumophila]]
[[Achondrogenesis]],
*[[Lidocaine]]
[[Acute Porphyria]],
*[[Lorazepam]]
[[Alpha 1-antitrypsin deficiency]],
*[[Lung cancer]]
[[Atelosteogenesis, type II]],
*[[Malignant hyperpyrexia]]
[[Becker's muscular dystrophy]],
*[[Malignant Mesothelioma]]
[[Carnitine palmitoyltransferase II deficiency]],
*[[Meningitis]]
[[Cystic fibrosis]],
*[[Metabolic Acidosis]]
[[Duchenne's Muscular Dystrophy]],
*[[Morphine]]
[[Familial dysautonomia]],
*[[Multiple organ dysfunction syndrome]]
[[Hereditary haemorrhagic telangiectasia]],
*[[Myasthenia Gravis]]
[[Osteogenesis imperfecta]],
*[[Myopathies]]
[[Thanatophoric dysplasia]]
*Near-drowning
[[Acute Porphyria]],
*Non-cardiogenic [[pulmonary edema]]
[[Cholesterol Emboli Syndrome]],
*[[Neuropathies]]
[[Fat embolism]],
*[[Nitrazepam]]
[[Sepsis]]
*[[Obesity]]
[[Blood transfusion]],
*[[Opiate]]
[[EVAR]]
*[[Osteogenesis imperfecta]]
[[Babesiosis]],
*[[Oxymorphone]]
[[Botulism]],
*[[Pegylated interferon alfa-2b]]
[[Crimean-Congo hemorrhagic fever]],
*[[Pleural effusion]]
[[Hantavirus Pulmonary Syndrome]],
*[[Pneumonia]]
[[Heartworm]],
*[[Pneumothorax]]
[[Post-polio syndrome]],
*[[Polyrediculitis]]
[[Rabies]],
*[[Post-polio syndrome]]
[[Tetanus]]
*[[Pramipexole]]
[[Kyphoscoliosis]]
*[[Procainamide]]
[[Amyotrophic Lateral Sclerosis]],
*[[Pulmonary alveolar proteinosis]]
[[Meningitis]],
*[[Pulmonary arterio-venous malformation]]
[[Polyrediculitis]],
*[[Pulmonary edema]]
[[Zellweger syndrome]]
*[[Pulmonary embolism]]
[[Metabolic Acidosis]]
*[[Pulmonary fibrosis]]
[[Malignant Mesothelioma]]
*[[Pulmonary hypertension]]
[[Acetylsalicylic acid]],
*[[Pulmonary edema]]
[[Alcohol]],
*[[Pulmonary valve stenosis]]
[[Bufotenin]],
*[[Pulmonary]] infection
[[Clitocybe dealbata]],
*Pre-operative [[tobacco smoking]]
[[Colchicine]],
*[[Rabies]]
[[Cytisine]],
*[[Rasburicase]]
[[Dicofol]],
*[[Respiratory distress syndrome (neonatal)]]
[[Saxitoxin]],
*[[Restrictive Lung Disease]]
[[Tetrodotoxin]],
*[[Reye's syndrome]]
[[Tick paralysis]],
*Sulfur dioxide
[[Vinyl chloride]]
*[[Satoyoshi syndrome]]
Acute lung syndrome,
*[[Saxitoxin]]
[[Acute Respiratory Distress Syndrome]],
*[[Sepsis]]
[[Alpha 1-antitrypsin deficiency]],
*[[Septic shock]]
[[Atelectasis]],
*[[Shock]]  
[[Bronchial asthma]],
*[[Smoke inhalation]]
[[Bronchiectasis]],
*[[Snakebites]]
[[Bronchiolitis]],
*[[Sodium thiopental]]
[[Bronchiolitis obliterans]],
*[[Status asthmaticus]]
[[Bronchogenic carcinoma]],
*[[Tetanus]]
[[Bronchopulmonary dysplasia]],
*[[Tetrodotoxin]]
[[Chronic Obstructive Pulmonary Disease]],
*[[Thanatophoric dysplasia]]
[[Cystic adenomatoid malformation of lung]],
*[[Tick paralysis]]
[[Emphysema]],
*[[Transposition of great arteries]]
[[Eosinophilic pneumonia]],
*[[Tretinoin]]
[[Fibrosing alveolitis]],
*[[Triazolam]]
[[Flail chest]],
*[[Tricuspid valve stenosis]]
[[Interstitial fibrosis]],
*Upper [[abdominal]] [[incision]]
[[Laryngo-/Bronchospasm]],
*[[Ventricular septal defect]]
[[Legionella pneumophila]]
*[[Vincristine *sulfate liposome]]
[[Pleural effusion]]
*[[Vinyl chloride]]
[[Pneumonia]]
*[[Zellweger syndrome]]
[[Pneumothorax]]
*[[Zopiclone]]
[[Pulmonary alveolar proteinosis]]
}}
[[Pulmonary arterio-venous malformation]]
[[Pulmonary edema]]
[[Pulmonary embolism]]
[[Pulmonary hypertension]]
[[Pulmonary oedema]]
[[Restrictive Lung Disease]]
[[Status asthmaticus]], [[Lung cancer]]
[[Acute motor axonal neuropathy]]
[[Anaphylaxis]]
[[Angioedema]]
[[Antiphospholipid Antibody Syndrome]]
[[Devic's disease]]
[[Guillain-Barre syndrome]]
[[Hamman-Rich Syndrome]]
[[Myasthenia Gravis]]
[[Satoyoshi syndrome]]
[[Ebstein anomaly]]
[[Flail chest]]
[[Aspiration]]
[[Foreign body]]
[[Malignant hyperpyrexia]]
[[Multiple organ dysfunction syndrome]]
Near-drowning
[[Reye's syndrome]]


==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WS}}


[[Category:Surgery]]
[[Category:Up-To-Date]]
[[Category:Medicine]]
[[Category:Emergency medicine]]
[[Category:Emergency medicine]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
 
[[Category:Anesthesiology]]
{{WH}}
{{WS}}

Latest revision as of 23:57, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]

Overview

Common causes of respiratory failure include pneumonia, pulmonary edema, pulmonary embolism, acute respiratory distress syndrome, atelectasis, asthma, COPD, neuromuscular and chest wall disorders, inadequate post-operative analgesia, smoking, obesity and shock. Life-threatening causes of respiratory failure include chronic obstructive pulmonary disease, acute on chronic respiratory failure, pulmonary infection, pulmonary embolism, heart failure, cardiac arrhythmia and lung cancer.

Causes

Life-threatening causes

Causes of respiratory failure based on classification of disease

Causes of respiratory failure based on classification of disease include:[2]

Drugs that can cause respiratory failure

Common drugs that can cause respiratory failure include:[4][5]

Causes by Organ System

Cardiovascular

Atrial septal defect (ostium primum), Ebstein anomaly, Eisenmenger syndrome, Fallot tetralogy, Pulmonary valve stenosis, Transposition of great arteries, Tricuspid valve stenosis, Ventricular septal defect, Heart failure, Cardiac arrhythmia, Shock

Chemical / poisoning 3-Quinuclidinyl benzilate,

Abrin, Aldicarb, Alpha-amanitin, Barium nitrate, Bungarotoxin, Carbon monoxide poisoning, Ceritinib Cocaine, Cone snail, Furfural, Snakebites (Patient information)

Congenital

Atrial septal defect (ostium primum), Bland-White-Garland Syndrome, Congenital Central Hypoventilation Syndrome, Congenital diaphragmatic hernia, Fallot tetralogy, Fetal circulation, persistent, Respiratory distress syndrome (neonatal)

Dermatologic No underlying causes
Drug Side Effect Codeine, Clozapine, Crizotinib, Cyclophosphamide, Desmopressin, Dornase Alfa, Fentanyl, Gamma-Hydroxybutyric acid, galsulfase, Heroin, Idursulfase, interferon alfacon-1, Ixabepilone, Ketamine, Lidocaine, Labetalol, Lorazepam, Morphine, Nitrazepam, Opiate, Oxymorphone, Pegylated interferon alfa-2b, Pramipexole, Procainamide (patient information), Rasburicase, Sodium thiopental, Tretinoin, Triazolam, Vincristine sulfate liposome, Zopiclone
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental

Asbestosis, Coal worker pneumoconiosis, Smoke inhalation, Sulfur dioxide

Gastroenterologic

Hepatic failure, Hepatopulmonary syndrome

Genetic

Achondrogenesis, Acute Porphyria, Alpha 1-antitrypsin deficiency, Atelosteogenesis, type II, Becker's muscular dystrophy, Carnitine palmitoyltransferase II deficiency, Cystic fibrosis, Duchenne's Muscular Dystrophy, Familial dysautonomia, Hereditary haemorrhagic telangiectasia, Osteogenesis imperfecta, Thanatophoric dysplasia

Hematologic

Acute Porphyria, Cholesterol Emboli Syndrome, Fat embolism, Sepsis

Iatrogenic

Blood transfusion, EVAR

Infectious Disease

Babesiosis, Botulism, Crimean-Congo hemorrhagic fever, Hantavirus Pulmonary Syndrome, Heartworm, Post-polio syndrome, Rabies, Tetanus

Musculoskeletal / Ortho

Kyphoscoliosis

Neurologic

Amyotrophic Lateral Sclerosis, Meningitis, Polyrediculitis, Zellweger syndrome

Nutritional / Metabolic

Metabolic Acidosis

Obstetric/Gynecologic No underlying causes
Oncologic

Malignant Mesothelioma

Ophthalmologic No underlying causes
Overdose / Toxicity

Acetylsalicylic acid, Alcohol, Bufotenin, Clitocybe dealbata, Colchicine, Cytisine, Dicofol, Saxitoxin, Tetrodotoxin, Tick paralysis, Vinyl chloride

Psychiatric No underlying causes
Pulmonary

Acute lung syndrome, Acute Respiratory Distress Syndrome, Alpha 1-antitrypsin deficiency, Atelectasis, Bronchial asthma, Bronchiectasis, Bronchiolitis, Bronchiolitis obliterans, Bronchogenic carcinoma, Bronchopulmonary dysplasia, Chronic Obstructive Pulmonary Disease, Cystic adenomatoid malformation of lung, Emphysema, Eosinophilic pneumonia, Fibrosing alveolitis, Flail chest, Interstitial fibrosis, Laryngo-/Bronchospasm, Legionella pneumophila, Pleural effusion, Pneumonia, Pneumothorax, Pulmonary alveolar proteinosis, Pulmonary arterio-venous malformation, Pulmonary edema, Pulmonary embolism, Pulmonary hypertension, Pulmonary oedema, Restrictive Lung Disease, Status asthmaticus, Lung cancer

Renal / Electrolyte

Electrolyte abnormalities

Rheum / Immune / Allergy

Acute motor axonal neuropathy, Anaphylaxis, Angioedema, Antiphospholipid Antibody Syndrome, Devic's disease, Guillain-Barre syndrome, Hamman-Rich Syndrome, Myasthenia Gravis, Satoyoshi syndrome

Trauma

Ebstein anomaly, Flail chest

Urologic No underlying causes
Miscellaneous

Aspiration, Foreign body, Malignant hyperpyrexia, Multiple organ dysfunction syndrome, Near-drowning, Reye's syndrome

Causes in Alphabetical Order

References

  1. Zielinski J, MacNee W, Wedzicha J, Ambrosino N, Braghiroli A, Dolensky J, Howard P, Gorzelak K, Lahdensuo A, Strom K, Tobiasz M, Weitzenblum E (February 1997). "Causes of death in patients with COPD and chronic respiratory failure". Monaldi Arch Chest Dis. 52 (1): 43–7. PMID 9151520.
  2. "Respiratory Failure | National Heart, Lung, and Blood Institute (NHLBI)".
  3. Roy TM, Walker JF, Farrow JR (April 1991). "Respiratory failure associated with myasthenia gravis". J Ky Med Assoc. 89 (4): 169–73. PMID 2040830.
  4. Caruso AL, Bouillon TW, Schumacher PM, Luginbuhl M, Morari M (2007). "Drug-induced respiratory depression: an integrated model of drug effects on the hypercapnic and hypoxic drive". Conf Proc IEEE Eng Med Biol Soc. 2007: 4259–63. doi:10.1109/IEMBS.2007.4353277. PMID 18002943.
  5. Wilson KC, Saukkonen JJ (2004). "Acute respiratory failure from abused substances". J Intensive Care Med. 19 (4): 183–93. doi:10.1177/0885066604263918. PMID 15296619.

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