Restless legs syndrome risk factors: Difference between revisions

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==Risk Factors==
==Risk Factors==
*There are no established risk factors for [disease name].
===Common Risk Factors===
OR
*Common risk factors in the development of RLS include:<ref name="pmid24747872">{{cite journal| author=Katsi V, Katsimichas T, Kallistratos MS, Tsekoura D, Makris T, Manolis AJ et al.| title=The association of Restless Legs Syndrome with hypertension and cardiovascular disease. | journal=Med Sci Monit | year= 2014 | volume= 20 | issue=  | pages= 654-9 | pmid=24747872 | doi=10.12659/MSM.890252 | pmc=3999161 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24747872  }} </ref><ref name="pmid18360657">{{cite journal| author=Cotter PE, O'Keeffe ST| title=Restless leg syndrome: is it a real problem? | journal=Ther Clin Risk Manag | year= 2006 | volume= 2 | issue= 4 | pages= 465-75 | pmid=18360657 | doi= | pmc=1936366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18360657  }} </ref><ref name="pmid26944272">{{cite journal| author=Trenkwalder C, Allen R, Högl B, Paulus W, Winkelmann J| title=Restless legs syndrome associated with major diseases: A systematic review and new concept. | journal=Neurology | year= 2016 | volume= 86 | issue= 14 | pages= 1336-43 | pmid=26944272 | doi=10.1212/WNL.0000000000002542 | pmc=4826337 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26944272  }} </ref><ref name="pmid28626420">{{cite journal| author=Guo S, Huang J, Jiang H, Han C, Li J, Xu X et al.| title=Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. | journal=Front Aging Neurosci | year= 2017 | volume= 9 | issue=  | pages= 171 | pmid=28626420 | doi=10.3389/fnagi.2017.00171 | pmc=5454050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28626420  }} </ref><ref name="DSMV">{{cite book | title = Diagnostic and statistical manual of mental disorders : DSM-5 | publisher = American Psychiatric Association | location = Washington, D.C | year = 2013 | isbn = 0890425558 }}</ref><ref name="pmid19514512">{{cite journal| author=Miyamoto M, Miyamoto T, Iwanami M, Suzuki K, Hirata K| title=[Pathophysiology of restless legs syndrome]. | journal=Brain Nerve | year= 2009 | volume= 61 | issue= 5 | pages= 523-32 | pmid=19514512 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19514512  }} </ref>
*The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
**Advancing age
**Family history of restless legs syndrome
**Female gender
**European descent


*Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
**[[Anxiety]]
===Common Risk Factors===
**[[Depression|Depr]]<nowiki/>t[[Depression|ession]]
*Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
**[[Iron deficiency]] [[Anemia]]
*Common risk factors in the development of [disease name] include:
**[[Kidney diseases]]
**[Risk factor 1]
**[[Stroke (patient information)|Stroke]]
**[Risk factor 2]
**[[Polyneuropathy]]
**[Risk factor 3]
**[[Multiple sclerosis]]


===Less Common Risk Factors===
===Less Common Risk Factors===
*Less common risk factors in the development of [disease name] include:
*Less common risk factors in the development of [disease name] include:<ref name="pmid24747872" /><ref name="pmid18360657" /><ref name="pmid26944272" /><ref name="pmid28626420" />
**[Risk factor 1]
**[[Parkinson disease]]
**[Risk factor 2]
**[[Cardiovascular disease|Cardiovascular diseases]]
**[Risk factor 3]
**[[Hypertension]]
 
==Risk Factors==
*Advancing age
*Family history of restless legs syndrome
*Female gender
*European descent<ref name=DSMV>{{cite book | title = Diagnostic and statistical manual of mental disorders : DSM-5 | publisher = American Psychiatric Association | location = Washington, D.C | year = 2013 | isbn = 0890425558 }}</ref>
 
 
 
 
 
The exact cause of RLS is not clear yet but the disease may be related to this conditions:<ref name="pmid28626420">{{cite journal| author=Guo S, Huang J, Jiang H, Han C, Li J, Xu X et al.| title=Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management. | journal=Front Aging Neurosci | year= 2017 | volume= 9 | issue=  | pages= 171 | pmid=28626420 | doi=10.3389/fnagi.2017.00171 | pmc=5454050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28626420  }} </ref><ref name="pmid24747872">{{cite journal| author=Katsi V, Katsimichas T, Kallistratos MS, Tsekoura D, Makris T, Manolis AJ et al.| title=The association of Restless Legs Syndrome with hypertension and cardiovascular disease. | journal=Med Sci Monit | year= 2014 | volume= 20 | issue=  | pages= 654-9 | pmid=24747872 | doi=10.12659/MSM.890252 | pmc=3999161 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24747872  }} </ref><ref name="pmid18360657">{{cite journal| author=Cotter PE, O'Keeffe ST| title=Restless leg syndrome: is it a real problem? | journal=Ther Clin Risk Manag | year= 2006 | volume= 2 | issue= 4 | pages= 465-75 | pmid=18360657 | doi= | pmc=1936366 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18360657  }} </ref><ref name="pmid26944272">{{cite journal| author=Trenkwalder C, Allen R, Högl B, Paulus W, Winkelmann J| title=Restless legs syndrome associated with major diseases: A systematic review and new concept. | journal=Neurology | year= 2016 | volume= 86 | issue= 14 | pages= 1336-43 | pmid=26944272 | doi=10.1212/WNL.0000000000002542 | pmc=4826337 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26944272  }} </ref>
*[[Hypertension]]
*[[Cardiovascular disease|Cardiovascular diseases]]
*[[Anxiety]]
*[[Depression]]
*[[Iron deficiency]]
*[[Anemia]]
*[[Kidney diseases]]
*[[Stroke (patient information)|Stroke]]
*[[Parkinson disease]]
*[[Polyneuropathy]]
*[[Multiple sclerosis]]
 
===Genetic Causes===
*[[Genes]] involved in the [[pathogenesis]] of RLS include: RLS 1: 12q and  RLS 2: 14q and RLS 3: 9p and RLS 4: 2q and RLS 5: 20p.<ref name="pmid19514512">{{cite journal| author=Miyamoto M, Miyamoto T, Iwanami M, Suzuki K, Hirata K| title=[Pathophysiology of restless legs syndrome]. | journal=Brain Nerve | year= 2009 | volume= 61 | issue= 5 | pages= 523-32 | pmid=19514512 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19514512  }} </ref>
*40% of cases of RLS are familial and are inherited in an [[autosomal dominant]] fashion with [[variable penetrance]].
 




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==References==
==References==
{{reflist|2}}
{{reflist|2}}
 
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{{WS}}


[[Category:Sleep disorders]]
[[Category:Sleep disorders]]
[[Category:Syndromes]]
[[Category:Syndromes]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Primary care]]
[[Category:Needs content]]
[[Category:Needs content]]
{{WH}}
{{WS}}

Latest revision as of 23:58, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

There are no established risk factors for [disease name].

OR

The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].

OR

Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.

Risk Factors

Common Risk Factors

  • Common risk factors in the development of RLS include:[1][2][3][4][5][6]
    • Advancing age
    • Family history of restless legs syndrome
    • Female gender
    • European descent

Less Common Risk Factors


References

  1. ↑ 1.0 1.1 Katsi V, Katsimichas T, Kallistratos MS, Tsekoura D, Makris T, Manolis AJ; et al. (2014). "The association of Restless Legs Syndrome with hypertension and cardiovascular disease". Med Sci Monit. 20: 654–9. doi:10.12659/MSM.890252. PMC 3999161. PMID 24747872.
  2. ↑ 2.0 2.1 Cotter PE, O'Keeffe ST (2006). "Restless leg syndrome: is it a real problem?". Ther Clin Risk Manag. 2 (4): 465–75. PMC 1936366. PMID 18360657.
  3. ↑ 3.0 3.1 Trenkwalder C, Allen R, Högl B, Paulus W, Winkelmann J (2016). "Restless legs syndrome associated with major diseases: A systematic review and new concept". Neurology. 86 (14): 1336–43. doi:10.1212/WNL.0000000000002542. PMC 4826337. PMID 26944272.
  4. ↑ 4.0 4.1 Guo S, Huang J, Jiang H, Han C, Li J, Xu X; et al. (2017). "Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management". Front Aging Neurosci. 9: 171. doi:10.3389/fnagi.2017.00171. PMC 5454050. PMID 28626420.
  5. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
  6. ↑ Miyamoto M, Miyamoto T, Iwanami M, Suzuki K, Hirata K (2009). "[Pathophysiology of restless legs syndrome]". Brain Nerve. 61 (5): 523–32. PMID 19514512.

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