Reactive arthritis laboratory findings: Difference between revisions
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== Overview == | ==Overview== | ||
Laboratory findings consistent with the diagnosis of reactive arthritis include elevated [[erythrocyte sedimentation rate]] ([[ESR]]), elevated [[C-reactive protein]] ([[C-reactive protein|CRP]]), and elevated total leukocyte count ([[TLC]]) showing increased [[polymorphonuclear cells]] ([[PMNs]]). [[Synovial fluid]] or [[synovial membrane]] biopsy for detection of [[bacterial]] [[DNA]] by [[polymerase chain reaction]] ([[Polymerase chain reaction|PCR]]) or [[immunofluorescence]] microscopy. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of reactive arthritis include: | Laboratory findings consistent with the diagnosis of reactive arthritis include:<ref name="pmid15084505">{{cite journal |vauthors=Colmegna I, Cuchacovich R, Espinoza LR |title=HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations |journal=Clin. Microbiol. Rev. |volume=17 |issue=2 |pages=348–69 |date=April 2004 |pmid=15084505 |pmc=387405 |doi= |url=}}</ref><ref name="pmid8835566">{{cite journal |vauthors=Locht H, Peen E, Skogh T |title=Antineutrophil cytoplasmic antibodies in reactive arthritis |journal=J. Rheumatol. |volume=22 |issue=12 |pages=2304–6 |date=December 1995 |pmid=8835566 |doi= |url=}}</ref> | ||
*Elevated ESR | *Elevated [[ESR]] | ||
*Elevated C-reactive protein | *Elevated [[C-reactive protein]] | ||
*Elevated TLC showing increased PMNs | *Elevated [[TLC]] showing increased [[PMNs]] | ||
*Synovial fluid analysis to determine cell count, culture, glucose, and presence of crystals. | *[[Synovial fluid]] analysis to determine cell count, [[Culture collection|culture]], [[glucose]], and presence of [[Crystal arthropathies|crystals]]. | ||
*Diagnostic lab evaluations include testing for HLA-B27, PCR or ELISA for reactive arthritis associated microorganisms. | *Diagnostic lab evaluations include testing for [[HLA-B27]], [[Polymerase chain reaction|PCR]] or [[Enzyme linked immunosorbent assay (ELISA)|ELISA]] for reactive arthritis associated microorganisms. | ||
** Laboratory evaluations required to establish infection with reactive arthritis causing organisms include routine | ** Laboratory evaluations required to establish infection with reactive arthritis causing organisms include routine [[urinalysis]], [[Culture collection|culture]] of [[Human feces|stool]] and [[urethral discharge]]. | ||
** Synovial fluid or synovial membrane biopsy for detection of bacterial DNA by PCR or immunofluorescence microscopy. | ** [[Synovial fluid]] or [[Synovial membranes|synovial membrane]] [[biopsy]] for detection of [[bacterial]] [[DNA]] by [[Polymerase chain reaction|PCR]] or [[immunofluorescence]] microscopy. | ||
** IgA antibodies to specific bacterial antigens | ** [[Immunoglobulin A|IgA antibodies]] to specific [[bacterial]] [[antigens]] | ||
*Other test include tuberculin skin test | *Other test include [[Tuberculin test|tuberculin]] skin test and [[Human Immunodeficiency Virus (HIV)|HIV]]. | ||
==References== | ==References== | ||
Latest revision as of 13:45, 12 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory findings consistent with the diagnosis of reactive arthritis include elevated erythrocyte sedimentation rate (ESR), elevated C-reactive protein (CRP), and elevated total leukocyte count (TLC) showing increased polymorphonuclear cells (PMNs). Synovial fluid or synovial membrane biopsy for detection of bacterial DNA by polymerase chain reaction (PCR) or immunofluorescence microscopy.
Laboratory Findings
Laboratory findings consistent with the diagnosis of reactive arthritis include:[1][2]
- Elevated ESR
- Elevated C-reactive protein
- Elevated TLC showing increased PMNs
- Synovial fluid analysis to determine cell count, culture, glucose, and presence of crystals.
- Diagnostic lab evaluations include testing for HLA-B27, PCR or ELISA for reactive arthritis associated microorganisms.
- Laboratory evaluations required to establish infection with reactive arthritis causing organisms include routine urinalysis, culture of stool and urethral discharge.
- Synovial fluid or synovial membrane biopsy for detection of bacterial DNA by PCR or immunofluorescence microscopy.
- IgA antibodies to specific bacterial antigens
- Other test include tuberculin skin test and HIV.
References
- ↑ Colmegna I, Cuchacovich R, Espinoza LR (April 2004). "HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations". Clin. Microbiol. Rev. 17 (2): 348–69. PMC 387405. PMID 15084505.
- ↑ Locht H, Peen E, Skogh T (December 1995). "Antineutrophil cytoplasmic antibodies in reactive arthritis". J. Rheumatol. 22 (12): 2304–6. PMID 8835566.