Chondroma natural history: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Chondroma}} | {{Chondroma}} | ||
{{CMG}}{{AE}} {{STM}} | {{CMG}}; {{AE}} {{F.K}}, {{STM}} | ||
==Overview== | ==Overview== | ||
Chondroma is usually diagnosed incidentally. Common [[complications]] of chondroma include [[malignant]] transformation into a low grade growth disturbance, pathologic fracture, especially in short tubular [[bones]] and recurrence. [[Benign]] chondromas have a good [[prognosis]] with appropriate treatment. | |||
==Natural History== | ==Natural History== | ||
* Chondroma is usually diagnosed incidentally.<ref name="pmid27696436">{{cite journal |vauthors=Deckers C, Schreuder BH, Hannink G, de Rooy JW, van der Geest IC |title=Radiologic follow-up of untreated enchondroma and atypical cartilaginous tumors in the long bones |journal=J Surg Oncol |volume=114 |issue=8 |pages=987–991 |date=December 2016 |pmid=27696436 |doi=10.1002/jso.24465 |url=}}</ref> | |||
* Chondroma grows slowly, with a mean time of 41 months between initial [[diagnosis]] and change in lesion. | |||
==Complications== | ==Complications== | ||
Common complications of chondroma include:<ref name="pmid3197353">{{cite journal |vauthors=Palaoglu S, Akkas O, Sav A |title=Chondroma of the cervical spine |journal=Clin Neurol Neurosurg |volume=90 |issue=3 |pages=253–5 |date=1988 |pmid=3197353 |doi= |url=}}</ref><ref name="pmid15285552">{{cite journal |vauthors=Müller PE, Dürr HR, Nerlich A, Pellengahr C, Maier M, Jansson V |title=Malignant transformation of a benign enchondroma of the hand to secondary chondrosarcoma with isolated pulmonary metastasis |journal=Acta Chir. Belg. |volume=104 |issue=3 |pages=341–4 |date=June 2004 |pmid=15285552 |doi= |url=}}</ref><ref name="pmid12354749">{{cite journal |vauthors=Martin JA, Forest E, Block JA, Klingelhutz AJ, Whited B, Gitelis S, Wilkey A, Buckwalter JA |title=Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation |journal=Cell Growth Differ. |volume=13 |issue=9 |pages=397–407 |date=September 2002 |pmid=12354749 |doi= |url=}}</ref><ref name="pmid21053879">{{cite journal |vauthors=Choi E, Wert M, Guerrieri C, Tucci J |title=A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma |journal=Orthopedics |volume=33 |issue=11 |pages=845 |date=November 2010 |pmid=21053879 |doi=10.3928/01477447-20100924-24 |url=}}</ref> | *Common complications of chondroma include:<ref name="pmid3197353">{{cite journal |vauthors=Palaoglu S, Akkas O, Sav A |title=Chondroma of the cervical spine |journal=Clin Neurol Neurosurg |volume=90 |issue=3 |pages=253–5 |date=1988 |pmid=3197353 |doi= |url=}}</ref><ref name="pmid15285552">{{cite journal |vauthors=Müller PE, Dürr HR, Nerlich A, Pellengahr C, Maier M, Jansson V |title=Malignant transformation of a benign enchondroma of the hand to secondary chondrosarcoma with isolated pulmonary metastasis |journal=Acta Chir. Belg. |volume=104 |issue=3 |pages=341–4 |date=June 2004 |pmid=15285552 |doi= |url=}}</ref><ref name="pmid12354749">{{cite journal |vauthors=Martin JA, Forest E, Block JA, Klingelhutz AJ, Whited B, Gitelis S, Wilkey A, Buckwalter JA |title=Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation |journal=Cell Growth Differ. |volume=13 |issue=9 |pages=397–407 |date=September 2002 |pmid=12354749 |doi= |url=}}</ref><ref name="pmid21053879">{{cite journal |vauthors=Choi E, Wert M, Guerrieri C, Tucci J |title=A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma |journal=Orthopedics |volume=33 |issue=11 |pages=845 |date=November 2010 |pmid=21053879 |doi=10.3928/01477447-20100924-24 |url=}}</ref> | ||
*[[Malignant]] transformation into a low grade chondrosarcoma | **[[Malignant]] transformation into a low grade [[chondrosarcoma]] | ||
*Growth disturbance | **Growth disturbance | ||
*Pathologic fracture, especially in short tubular | **Pathologic [[fracture]], especially in short tubular [[bones]] | ||
*Recurrence | **Recurrence | ||
==Prognosis== | ==Prognosis== | ||
*Benign [[Chondroma|chondromas]] have a good [[prognosis]] with aprropriate treatment.<ref name="pmid1888368">{{cite journal |vauthors=Freilich H |title=Breast cancer screening |journal=Med. J. Aust. |volume=154 |issue=11 |pages=781–2 |date=June 1991 |pmid=1888368 |doi= |url=}}</ref> | |||
*Most patients with [[chondroma]] under treatment remain [[asymptomatic]] and the disease may rarely recur.<ref name="pmid12271817">{{cite journal |vauthors=Rozeman LB, Hogendoorn PC, Bovée JV |title=Diagnosis and prognosis of chondrosarcoma of bone |journal=Expert Rev. Mol. Diagn. |volume=2 |issue=5 |pages=461–72 |date=September 2002 |pmid=12271817 |doi=10.1586/14737159.2.5.461 |url=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 20:40, 24 January 2019
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Chondroma natural history On the Web |
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Risk calculators and risk factors for Chondroma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2], Soujanya Thummathati, MBBS [3]
Overview
Chondroma is usually diagnosed incidentally. Common complications of chondroma include malignant transformation into a low grade growth disturbance, pathologic fracture, especially in short tubular bones and recurrence. Benign chondromas have a good prognosis with appropriate treatment.
Natural History
- Chondroma is usually diagnosed incidentally.[1]
- Chondroma grows slowly, with a mean time of 41 months between initial diagnosis and change in lesion.
Complications
- Common complications of chondroma include:[2][3][4][5]
- Malignant transformation into a low grade chondrosarcoma
- Growth disturbance
- Pathologic fracture, especially in short tubular bones
- Recurrence
Prognosis
- Benign chondromas have a good prognosis with aprropriate treatment.[6]
- Most patients with chondroma under treatment remain asymptomatic and the disease may rarely recur.[7]
References
- ↑ Deckers C, Schreuder BH, Hannink G, de Rooy JW, van der Geest IC (December 2016). "Radiologic follow-up of untreated enchondroma and atypical cartilaginous tumors in the long bones". J Surg Oncol. 114 (8): 987–991. doi:10.1002/jso.24465. PMID 27696436.
- ↑ Palaoglu S, Akkas O, Sav A (1988). "Chondroma of the cervical spine". Clin Neurol Neurosurg. 90 (3): 253–5. PMID 3197353.
- ↑ Müller PE, Dürr HR, Nerlich A, Pellengahr C, Maier M, Jansson V (June 2004). "Malignant transformation of a benign enchondroma of the hand to secondary chondrosarcoma with isolated pulmonary metastasis". Acta Chir. Belg. 104 (3): 341–4. PMID 15285552.
- ↑ Martin JA, Forest E, Block JA, Klingelhutz AJ, Whited B, Gitelis S, Wilkey A, Buckwalter JA (September 2002). "Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation". Cell Growth Differ. 13 (9): 397–407. PMID 12354749.
- ↑ Choi E, Wert M, Guerrieri C, Tucci J (November 2010). "A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma". Orthopedics. 33 (11): 845. doi:10.3928/01477447-20100924-24. PMID 21053879.
- ↑ Freilich H (June 1991). "Breast cancer screening". Med. J. Aust. 154 (11): 781–2. PMID 1888368.
- ↑ Rozeman LB, Hogendoorn PC, Bovée JV (September 2002). "Diagnosis and prognosis of chondrosarcoma of bone". Expert Rev. Mol. Diagn. 2 (5): 461–72. doi:10.1586/14737159.2.5.461. PMID 12271817.