Microscopic polyangiitis causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Microscopic polyangiitis}} | {{Microscopic polyangiitis}} | ||
{{CMG}} | {{CMG}};{{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
There are no known direct causes for Microscopic polyangiitis.Microscopic polyangiitis can affect individuals from all ethnicities and | There are no known direct causes for [[Microscopic polyangiitis]]. [[Microscopic polyangiitis]] can affect individuals from all ethnicities and of any age group.[[Vasculitis]] is a common term that refers to [[inflammation]] of the [[Blood vessel|blood vessels]] in the body. When the [[inflammation]] progress it lead to weakening and stretch of the [[Blood vessel|blood vessels]] and forms a [[an aneurysm]]. | ||
==Causes== | ==Causes== | ||
=== Common Causes === | |||
There are no known direct common causes for Microscopic polyangiitis. However microscopic polyangiitis may be caused by:<ref name="pmid12849060">{{cite journal |vauthors=Kallenberg CG, Rarok A, Stegeman CA, Limburg PC |title=New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis |journal=Autoimmun Rev |volume=1 |issue=1-2 |pages=61–6 |date=February 2002 |pmid=12849060 |doi= |url=}}</ref><ref name="pmid17699427">{{cite journal |vauthors=Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ |title=Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study |journal=Clin J Am Soc Nephrol |volume=2 |issue=2 |pages=290–9 |date=March 2007 |pmid=17699427 |pmc=4049534 |doi=10.2215/CJN.03501006 |url=}}</ref><ref name="pmid235555272">{{cite journal |vauthors=Tsuchiya N |title=Genetics of microscopic polyangiitis in the Japanese population |journal=Ann Vasc Dis |volume=5 |issue=3 |pages=289–95 |date=2012 |pmid=23555527 |pmc=3595849 |doi=10.3400/avd.ra.12.00062 |url=}}</ref> | |||
* Autoimmune mechanism | * [[Autoimmune]] mechanism | ||
* Infections | * [[Infection|Infections]] | ||
* Malignancy | * [[:Category:Drugs|Drugs]] | ||
* | |||
=== Less Common Causes === | |||
* Silica exposure | |||
* [[Malignancy]] | |||
=== Genetic Causes === | |||
* [[HLA]]-DRB1*09:01-DQB1*03:03 [[haplotype]] [[Gene|genes]] shows a significant increase in the association with [[Microscopic polyangiitis]].<ref name="pmid23555527">{{cite journal |vauthors=Tsuchiya N |title=Genetics of microscopic polyangiitis in the Japanese population |journal=Ann Vasc Dis |volume=5 |issue=3 |pages=289–95 |date=2012 |pmid=23555527 |pmc=3595849 |doi=10.3400/avd.ra.12.00062 |url=}}</ref> | |||
* These [[Haplotype|haplotypes]] are mostly found in Japanese population.<ref name="pmid16208405">{{cite journal |vauthors=Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K |title=Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese |journal=Genes Immun. |volume=7 |issue=1 |pages=81–4 |date=January 2006 |pmid=16208405 |doi=10.1038/sj.gene.6364262 |url=}}</ref> | |||
* Activation of [[Natural killer cell|NK/]] [[T cell|T cells]] may also lead to [[predisposition]] to [[Microscopic polyangiitis]].<ref name="pmid15248031">{{cite journal |vauthors=Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M |title=Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals |journal=Cancer Immunol. Immunother. |volume=54 |issue=2 |pages=172–8 |date=February 2005 |pmid=15248031 |doi=10.1007/s00262-004-0575-z |url=}}</ref><ref name="pmid16508981">{{cite journal |vauthors=Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K |title=Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis |journal=Arthritis Rheum. |volume=54 |issue=3 |pages=992–7 |date=March 2006 |pmid=16508981 |doi=10.1002/art.21653 |url=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 16:51, 7 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
There are no known direct causes for Microscopic polyangiitis. Microscopic polyangiitis can affect individuals from all ethnicities and of any age group.Vasculitis is a common term that refers to inflammation of the blood vessels in the body. When the inflammation progress it lead to weakening and stretch of the blood vessels and forms a an aneurysm.
Causes
Common Causes
There are no known direct common causes for Microscopic polyangiitis. However microscopic polyangiitis may be caused by:[1][2][3]
- Autoimmune mechanism
- Infections
- Drugs
Less Common Causes
- Silica exposure
- Malignancy
Genetic Causes
- HLA-DRB1*09:01-DQB1*03:03 haplotype genes shows a significant increase in the association with Microscopic polyangiitis.[4]
- These haplotypes are mostly found in Japanese population.[5]
- Activation of NK/ T cells may also lead to predisposition to Microscopic polyangiitis.[6][7]
References
- ↑ Kallenberg CG, Rarok A, Stegeman CA, Limburg PC (February 2002). "New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis". Autoimmun Rev. 1 (1–2): 61–6. PMID 12849060.
- ↑ Hogan SL, Cooper GS, Savitz DA, Nylander-French LA, Parks CG, Chin H, Jennette CE, Lionaki S, Jennette JC, Falk RJ (March 2007). "Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control study". Clin J Am Soc Nephrol. 2 (2): 290–9. doi:10.2215/CJN.03501006. PMC 4049534. PMID 17699427.
- ↑ Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N (2012). "Genetics of microscopic polyangiitis in the Japanese population". Ann Vasc Dis. 5 (3): 289–95. doi:10.3400/avd.ra.12.00062. PMC 3595849. PMID 23555527.
- ↑ Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (January 2006). "Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese". Genes Immun. 7 (1): 81–4. doi:10.1038/sj.gene.6364262. PMID 16208405.
- ↑ Naumova E, Mihaylova A, Stoitchkov K, Ivanova M, Quin L, Toneva M (February 2005). "Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals". Cancer Immunol. Immunother. 54 (2): 172–8. doi:10.1007/s00262-004-0575-z. PMID 15248031.
- ↑ Miyashita R, Tsuchiya N, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K (March 2006). "Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis". Arthritis Rheum. 54 (3): 992–7. doi:10.1002/art.21653. PMID 16508981.