Monoarthritis with morning stiffness

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Diseases			Clinical manifestations							Para-clinical findings								Gold standard	Additional findings
			Symptoms				Physical examination
										Lab Findings				Imaging			Histopathology
			Joint Swelling	Fever	Weight loss	Claudication	Morning stiffness	Local erythema	Skin manifestation	CBC	ESR	Synovial fluid	Other	X-ray	CT scan	Other
Monoarthritis	Infection	Mycobacterial infection	-	+	+	+	+/-	-	Local erythema	Leukocytosis, Normocytic normochromic anemia	↑	Moderately elevated WBC counts (neutrophilic predominance), low glucose, and increased protein	PPD	Tissue swelling, Bone destruction with normal joint space, Osteopenia	Vertebral anterior portion collapse	Complicated effusion with partial joint destruction and erosion in MRI	Granulomatous inflammation	Synovial fluid culture	Limping, Malaise, Chronic cough
	Systemic disorders	Inflammatory bowel disease-associated arthritis	+	+	-	-	+	+/-	Pyoderma gangrenosum(ulcerative colitis),Erythema nodosum(Crohn disease)	Iron deficiency anemia, Leukocytosis, Thrombocytosis	↑	Mild to moderate inflammatory fluid, PMNpredominance	↑RF, Antiendomysial Ab,Antitransglutaminase Ab	Bilateral sacroiliitis, Syndesmophytes and apophyseal joint involvement in spine	-	Early detection of spinal and sacroiliac lesions in MRI	-	Clinical findings and history	Acute anterior uveitis
		Rheumatoid arthritis	+	-	+	+	+	-	Rheumatoid nodules	Anemia, Thrombocytosis	↑	WBC count >2000/µL (generally 5000-50,000/µL), with neutrophilpredominance (60-80%)	Anti-CCP Ab, Hyperuricemia	Joint-space narrowing	Microfractures	Synovitis in MRI	Influx of inflammatory cells into the synovial membrane, withangiogenesis	Clinical findings coupled anti-CCP antibody	Rheumatoid nodules

References