Membranous glomerulonephritis laboratory findings: Difference between revisions
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{{Membranous glomerulonephritis}} | {{Membranous glomerulonephritis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{SAH}} | ||
==Overview== | ==Overview== | ||
The major laboratory workup includes [[blood]] workup like complete blood count, [[auto-immune]] workup [[ANA]], [[anti]][[dsDNA]], anti-Sm, anti-Ro/SSA, and anti-La/SSBand, [[Anti]]-[[PLA2R]] [[antibody]], [[urine]] workup like 24 hours urine collection for protein quantification. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* Comprehensive chemistry panel including serum albumin | * The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup:<ref name="pmid21566055">{{cite journal |vauthors=Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z |title=Anti-phospholipase A2 receptor antibody in membranous nephropathy |journal=J. Am. Soc. Nephrol. |volume=22 |issue=6 |pages=1137–43 |date=June 2011 |pmid=21566055 |pmc=3103733 |doi=10.1681/ASN.2010090967 |url=}}</ref><ref name="pmid22956816">{{cite journal |vauthors=Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF |title=Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy |journal=J. Am. Soc. Nephrol. |volume=23 |issue=10 |pages=1735–43 |date=October 2012 |pmid=22956816 |pmc=3458465 |doi=10.1681/ASN.2012030242 |url=}}</ref> | ||
* Complete blood count | ** Comprehensive chemistry panel including serum [[albumin]] | ||
* Urinalysis with examination of the sediment | **[[Complete blood count]] | ||
* 24-hour urine collection for protein quantification and creatinine clearance | **[[Urinalysis]] with examination of the sediment | ||
* ANA and, if positive, anti-double-stranded DNA (anti | **24-hour urine collection for protein quantification and [[creatinine clearance]] | ||
* Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV | **[[ANA]] and, if positive, [[anti-double-stranded DNA]] (anti[[dsDNA]]), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies to rule out [[autoimmune disease]] ([[SLE]]) | ||
* Serum C3 and C4 complement levels | **Tests for [[hepatitis B]] and [[Hepatitis C|C]] [[viruses]] and the [[Human Immunodeficiency Virus|human immunodeficiency virus]] ([[HIV]]) | ||
* | **Serum [[C3]] and [[C4]] [[complement]] levels | ||
* | **Serum free light chains (SFLCs) and [[serum protein electrophoresis]] (SPEP) with immunofixation | ||
**[[Phospholipase-A2-receptor antibody]] ([[Anti]]-[[PLA2R]] [[antibody]]) by enzyme-linked immunosorbent assay ([[ELISA]]) | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category: | |||
[[Category:Nephrology]] | |||
[[Category:Up-to-date]] | |||
Latest revision as of 22:41, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
The major laboratory workup includes blood workup like complete blood count, auto-immune workup ANA, antidsDNA, anti-Sm, anti-Ro/SSA, and anti-La/SSBand, Anti-PLA2R antibody, urine workup like 24 hours urine collection for protein quantification.
Laboratory Findings
- The laboratory workup of membranous glomerulonephritis includes blood, urine and anti-bodies workup:[1][2]
- Comprehensive chemistry panel including serum albumin
- Complete blood count
- Urinalysis with examination of the sediment
- 24-hour urine collection for protein quantification and creatinine clearance
- ANA and, if positive, anti-double-stranded DNA (antidsDNA), anti-Sm, anti-Ro/SSA, and anti-La/SSB antibodies to rule out autoimmune disease (SLE)
- Tests for hepatitis B and C viruses and the human immunodeficiency virus (HIV)
- Serum C3 and C4 complement levels
- Serum free light chains (SFLCs) and serum protein electrophoresis (SPEP) with immunofixation
- Phospholipase-A2-receptor antibody (Anti-PLA2R antibody) by enzyme-linked immunosorbent assay (ELISA)
References
- ↑ Qin W, Beck LH, Zeng C, Chen Z, Li S, Zuo K, Salant DJ, Liu Z (June 2011). "Anti-phospholipase A2 receptor antibody in membranous nephropathy". J. Am. Soc. Nephrol. 22 (6): 1137–43. doi:10.1681/ASN.2010090967. PMC 3103733. PMID 21566055.
- ↑ Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF (October 2012). "Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy". J. Am. Soc. Nephrol. 23 (10): 1735–43. doi:10.1681/ASN.2012030242. PMC 3458465. PMID 22956816.