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{{Membranous glomerulonephritis}}
{{Membranous glomerulonephritis}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{SAH}}


==Overview==
==Overview==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].


OR
The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Approximately 5-30% patients with MN have spontanous remission. Common complications of membranous glomerulonephritis include [[renal failure]], [[hypertension]], [[proteinuria]], [[dyslipidemia]], [[hypercoagulable state]] leading to [[thromboembolism]], Increased risk of [[infection]]. Prognosis is generally good, and 1 year [[mortality rate]] of patients with membranous glomerulonephritis is approximately 0.38%. The presence of [[proteinuria]] and baseline [[renal insuffiency]] are  associated with a particularly poor prognosis among patients with membranous glomerulonephritis. Membranous glomerulonephritis caused by [[NSAIDS]] is associated with the most favorable prognosis.


Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
==Natural History==
*The natural history of membranous glomerulonephritis (MN) is given below:<ref name="pmid11132040">{{cite journal |vauthors=Kerjaschki D |title=Pathogenetic concepts of membranous glomerulopathy (MGN) |journal=J. Nephrol. |volume=13 Suppl 3 |issue= |pages=S96–100 |date=2000 |pmid=11132040 |doi= |url=}}</ref><ref name="pmid8510707">{{cite journal |vauthors=Schieppati A, Mosconi L, Perna A, Mecca G, Bertani T, Garattini S, Remuzzi G |title=Prognosis of untreated patients with idiopathic membranous nephropathy |journal=N. Engl. J. Med. |volume=329 |issue=2 |pages=85–9 |date=July 1993 |pmid=8510707 |doi=10.1056/NEJM199307083290203 |url=}}</ref>
**The symptoms of MN usually develop in the fourth decade of life in males.
**The presence of symptoms of MN young female is suggestive of lupus.
**Approximately 5-30% patients with MN have spontanous remission.


OR
==Complications==
*Common complications of membranous glomerulonepharitis include:<ref name="pmid24715030">{{cite journal |vauthors=Debiec H, Ronco P |title=Immunopathogenesis of membranous nephropathy: an update |journal=Semin Immunopathol |volume=36 |issue=4 |pages=381–97 |date=July 2014 |pmid=24715030 |doi=10.1007/s00281-014-0423-y |url=}}</ref><ref name="pmid23689576">{{cite journal| author=Barbour S, Reich H, Cattran D| title=Short-term complications of membranous nephropathy. | journal=Contrib Nephrol | year= 2013 | volume= 181 | issue=  | pages= 143-51 | pmid=23689576 | doi=10.1159/000349976 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23689576  }}</ref>
**[[Renal failure]]
**Symptoms associated with the nephrotic syndrome:
***[[Hypertension]]
***[[Proteinuria]]
***[[Edema]]
***[[Dyslipidemia]].
**[[Hypercoagulable state]] leading to [[thromboembolism]]
**Increased risk of [[infection]]


Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Prognosis ==
==Natural History, Complications, and Prognosis==
* The prognostic  factors of membranous glomerulonephritis are given below:<ref name="pmid10495797">{{cite journal |vauthors=Wasserstein AG |title=Membranous glomerulonephritis |journal=J. Am. Soc. Nephrol. |volume=8 |issue=4 |pages=664–74 |date=April 1997 |pmid=10495797 |doi= |url=}}</ref><ref name="McGroganFranssen2010">{{cite journal|last1=McGrogan|first1=A.|last2=Franssen|first2=C. F. M.|last3=de Vries|first3=C. S.|title=The incidence of primary glomerulonephritis worldwide: a systematic review of the literature|journal=Nephrology Dialysis Transplantation|volume=26|issue=2|year=2010|pages=414–430|issn=0931-0509|doi=10.1093/ndt/gfq665}}</ref>
 
** Prognosis is generally good, and 1 year [[mortality rate]] of patients with membranous glomerulonephritis is approximately 0.38%.
===Natural History===
** Depending on the extent of the membranous glomerulonephritis at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.  
** The presence of [[proteinuria]] and baseline [[renal insuffiency]] are  associated with a particularly poor prognosis among patients with membranous glomerulonephritis.
*The symptoms of (disease name) typically develop ___ years after exposure to ___.  
** Membranous glomerulonephritis caused by [[NSAIDS]] is associated with the most favorable prognosis.
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
** The prognosis of membranous glomerulonephritis associated with [[hepatitis B]] has less favorable prognosis.
 
===Complications===
*Common complications of [disease name] include:
**[Complication 1]
**[Complication 2]
**[Complication 3]
 
===Prognosis===
* Spontaneous remission is most likely in women, children, those with lesser amounts of proteinuria, and adults under age 50 years with a normal serum creatinine concentration and benign histologic features [1-3,8].
* Although unproven, the rate of partial remission may be higher with the use of ACE inhibitors or ARBs.


==References==
==References==
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Latest revision as of 22:41, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]

Overview

The symptoms of membranous glomerulonephritis usually develop in the fourth decade of life in males. Approximately 5-30% patients with MN have spontanous remission. Common complications of membranous glomerulonephritis include renal failure, hypertension, proteinuria, dyslipidemia, hypercoagulable state leading to thromboembolism, Increased risk of infection. Prognosis is generally good, and 1 year mortality rate of patients with membranous glomerulonephritis is approximately 0.38%. The presence of proteinuria and baseline renal insuffiency are associated with a particularly poor prognosis among patients with membranous glomerulonephritis. Membranous glomerulonephritis caused by NSAIDS is associated with the most favorable prognosis.

Natural History

  • The natural history of membranous glomerulonephritis (MN) is given below:[1][2]
    • The symptoms of MN usually develop in the fourth decade of life in males.
    • The presence of symptoms of MN young female is suggestive of lupus.
    • Approximately 5-30% patients with MN have spontanous remission.

Complications

Prognosis

  • The prognostic factors of membranous glomerulonephritis are given below:[5][6]
    • Prognosis is generally good, and 1 year mortality rate of patients with membranous glomerulonephritis is approximately 0.38%.
    • Depending on the extent of the membranous glomerulonephritis at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.
    • The presence of proteinuria and baseline renal insuffiency are associated with a particularly poor prognosis among patients with membranous glomerulonephritis.
    • Membranous glomerulonephritis caused by NSAIDS is associated with the most favorable prognosis.
    • The prognosis of membranous glomerulonephritis associated with hepatitis B has less favorable prognosis.

References

  1. ↑ Kerjaschki D (2000). "Pathogenetic concepts of membranous glomerulopathy (MGN)". J. Nephrol. 13 Suppl 3: S96–100. PMID 11132040.
  2. ↑ Schieppati A, Mosconi L, Perna A, Mecca G, Bertani T, Garattini S, Remuzzi G (July 1993). "Prognosis of untreated patients with idiopathic membranous nephropathy". N. Engl. J. Med. 329 (2): 85–9. doi:10.1056/NEJM199307083290203. PMID 8510707.
  3. ↑ Debiec H, Ronco P (July 2014). "Immunopathogenesis of membranous nephropathy: an update". Semin Immunopathol. 36 (4): 381–97. doi:10.1007/s00281-014-0423-y. PMID 24715030.
  4. ↑ Barbour S, Reich H, Cattran D (2013). "Short-term complications of membranous nephropathy". Contrib Nephrol. 181: 143–51. doi:10.1159/000349976. PMID 23689576.
  5. ↑ Wasserstein AG (April 1997). "Membranous glomerulonephritis". J. Am. Soc. Nephrol. 8 (4): 664–74. PMID 10495797.
  6. ↑ McGrogan, A.; Franssen, C. F. M.; de Vries, C. S. (2010). "The incidence of primary glomerulonephritis worldwide: a systematic review of the literature". Nephrology Dialysis Transplantation. 26 (2): 414–430. doi:10.1093/ndt/gfq665. ISSN 0931-0509.

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