Renal tubular acidosis causes: Difference between revisions
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{{Renal tubular acidosis}} | {{Renal tubular acidosis}} | ||
{{CMG}} ; {{AE}} {{ADG}} | {{CMG}} ; {{AE}} {{ADG}} {{JSS}} {{SAH}} | ||
==Ovevriew== | ==Ovevriew== | ||
Primary causes of renal tubular acidosis include genetic [[mutations]] causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells and congenital adrenal hyperplasia. Secondary causes include medications and autoimmune diseases. | Primary causes of renal tubular acidosis include genetic [[mutations]] causing defects in the kidney [[anion]] exchanger [kAE1] in [[Distal convoluted tubule|distal]] tubule intercalated cells and [[congenital adrenal hyperplasia]]. Secondary causes include medications and [[Autoimmune disease|autoimmune]] diseases. | ||
==Causes== | ==Causes== | ||
The following table summarizes the common primary and secondary causes of renal tubular acidosis.<ref name="pmid23235953">{{cite journal |vauthors=Haque SK, Ariceta G, Batlle D |title=Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies |journal=Nephrol. Dial. Transplant. |volume=27 |issue=12 |pages=4273–87 |date=December 2012 |pmid=23235953 |pmc=3616759 |doi=10.1093/ndt/gfs493 |url=}}</ref><ref name="pmid23114896">{{cite journal |vauthors=Batlle D, Haque SK |title=Genetic causes and mechanisms of distal renal tubular acidosis |journal=Nephrol. Dial. Transplant. |volume=27 |issue=10 |pages=3691–704 |date=October 2012 |pmid=23114896 |doi=10.1093/ndt/gfs442 |url=}}</ref><ref name="pmid21170890">{{cite journal |vauthors=Alper SL |title=Familial renal tubular acidosis |journal=J. Nephrol. |volume=23 Suppl 16 |issue= |pages=S57–76 |date=2010 |pmid=21170890 |doi= |url=}}</ref> | The following table summarizes the common primary and secondary causes of [[renal tubular acidosis]].<ref name="pmid23235953">{{cite journal |vauthors=Haque SK, Ariceta G, Batlle D |title=Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies |journal=Nephrol. Dial. Transplant. |volume=27 |issue=12 |pages=4273–87 |date=December 2012 |pmid=23235953 |pmc=3616759 |doi=10.1093/ndt/gfs493 |url=}}</ref><ref name="pmid23114896">{{cite journal |vauthors=Batlle D, Haque SK |title=Genetic causes and mechanisms of distal renal tubular acidosis |journal=Nephrol. Dial. Transplant. |volume=27 |issue=10 |pages=3691–704 |date=October 2012 |pmid=23114896 |doi=10.1093/ndt/gfs442 |url=}}</ref><ref name="pmid21170890">{{cite journal |vauthors=Alper SL |title=Familial renal tubular acidosis |journal=J. Nephrol. |volume=23 Suppl 16 |issue= |pages=S57–76 |date=2010 |pmid=21170890 |doi= |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! | ! | ||
| Line 15: | Line 15: | ||
|Type 1 | |Type 1 | ||
| | | | ||
* Idiopathic | * [[Idiopathic]] | ||
* Familial | * [[Familial]] | ||
** Autosomal dominant | ** Autosomal dominant | ||
*** Mainly due to [[mutations]] causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells. | *** Mainly due to [[mutations]] causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells. | ||
| Line 29: | Line 29: | ||
** [[Lithium carbonate]] | ** [[Lithium carbonate]] | ||
** [[Ibuprofen]] | ** [[Ibuprofen]] | ||
* Hypercalciuric conditions | * [[Hypercalciuric]] conditions | ||
** [[Hyperparathyroidism]] | ** [[Hyperparathyroidism]] | ||
** [[Vitamin D -- adverse effects|Vitamin D intoxication]] | ** [[Vitamin D -- adverse effects|Vitamin D intoxication]] | ||
| Line 38: | Line 38: | ||
|Type 2 | |Type 2 | ||
| | | | ||
* | * [[Recessive]] | ||
** Proximal tubule cell sodium bicarbonate co-transporter (NBCe1) defect | ** Proximal tubule cell sodium bicarbonate co-transporter (NBCe1) defect | ||
** Carbonic anhydrase type 2 deficiency | ** Carbonic anhydrase type 2 deficiency | ||
Latest revision as of 13:35, 1 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2] Jogeet Singh Sekhon, M.D. [3] Syed Ahsan Hussain, M.D.[4]
Ovevriew
Primary causes of renal tubular acidosis include genetic mutations causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells and congenital adrenal hyperplasia. Secondary causes include medications and autoimmune diseases.
Causes
The following table summarizes the common primary and secondary causes of renal tubular acidosis.[1][2][3]
| Primary Causes | Secondary Causes | |
|---|---|---|
| Type 1 | ||
| Type 2 |
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| Type 4 |
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References
- ↑ Haque SK, Ariceta G, Batlle D (December 2012). "Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies". Nephrol. Dial. Transplant. 27 (12): 4273–87. doi:10.1093/ndt/gfs493. PMC 3616759. PMID 23235953.
- ↑ Batlle D, Haque SK (October 2012). "Genetic causes and mechanisms of distal renal tubular acidosis". Nephrol. Dial. Transplant. 27 (10): 3691–704. doi:10.1093/ndt/gfs442. PMID 23114896.
- ↑ Alper SL (2010). "Familial renal tubular acidosis". J. Nephrol. 23 Suppl 16: S57–76. PMID 21170890.