Myoglobinuria overview: Difference between revisions
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[[Myoglobinuria]] is the presence of [[myoglobin]] in the urine, usually associated with [[rhabdomyolysis]] or muscle destruction. | [[Myoglobinuria]] is the presence of [[myoglobin]] in the urine, usually associated with [[rhabdomyolysis]] or muscle destruction. [[Myoglobin]] ('''Mb''' or '''MB''') is an [[iron- and oxygen-binding protein]] found in [[muscles]]. Myoglobin is present in [[muscle]] cells as a reserve of [[oxygen]].In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.<ref name=Nelson00>{{cite book | author = Nelson DL, Cox MM | title = Lehninger Principles of Biochemistry | publisher = Worth Publishers | location = New York | year = 2000 | page = 206 | edition = 3rd | isbn = 0-7167-6203-X | url=https://books.google.com/books?id=5Ek9J4p3NfkC&dq=nelson+2000+Lehninger+Principles+of+Biochemistry&q=myoglobin}} (Google books link is the 2008 edition)</ref> Myoglobin is the primary [[oxygen]]-carrying [[biological pigment|pigment]] of muscle tissues.<ref name="review">{{cite journal | vauthors = Ordway GA, Garry DJ | title = Myoglobin: an essential hemoprotein in striated muscle | journal = The Journal of Experimental Biology | volume = 207 | issue = Pt 20 | pages = 3441–6 | date = Sep 2004 | pmid = 15339940 | doi = 10.1242/jeb.01172 }}</ref> High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin.<ref name=Nelson00/> Myoglobin is found in Type I muscle, Type II A and Type II B, but most texts consider myoglobin not to be found in [[smooth muscle tissue|smooth muscle]]. | ||
==References== | ==References== | ||
Latest revision as of 15:27, 15 August 2018
Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction. Myoglobin (Mb or MB) is an iron- and oxygen-binding protein found in muscles. Myoglobin is present in muscle cells as a reserve of oxygen.In humans, myoglobin is only found in the bloodstream after muscle injury. It is an abnormal finding, and can be diagnostically relevant when found in blood.[1] Myoglobin is the primary oxygen-carrying pigment of muscle tissues.[2] High concentrations of myoglobin in muscle cells allow organisms to hold their breath for a longer period of time. Diving mammals such as whales and seals have muscles with particularly high abundance of myoglobin.[1] Myoglobin is found in Type I muscle, Type II A and Type II B, but most texts consider myoglobin not to be found in smooth muscle.
References
- ↑ 1.0 1.1 Nelson DL, Cox MM (2000). Lehninger Principles of Biochemistry (3rd ed.). New York: Worth Publishers. p. 206. ISBN 0-7167-6203-X. (Google books link is the 2008 edition)
- ↑ Ordway GA, Garry DJ (Sep 2004). "Myoglobin: an essential hemoprotein in striated muscle". The Journal of Experimental Biology. 207 (Pt 20): 3441–6. doi:10.1242/jeb.01172. PMID 15339940.