Hemolytic-uremic syndrome history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{HUS}} | {{HUS}} | ||
{{CMG}}; {{AE}} | {{CMG}} {{shyam}}; {{AE}} {{S.G.}}, {{AHS}} | ||
==Overview== | ==Overview== | ||
The majority of patients with Hemolytic | The majority of patients with [[Hemolytic-uremic syndrome|hemolytic uremic syndrome]] ([[Hemolytic-uremic syndrome|HUS]]) are [[asymptomatic]]. It usually start with [[gastrointestinal]] [[prodrome]] including [[bloody diarrhea]] and [[fever]] that may occur 2-7 days before the onset of [[renal failure]]. Other [[Symptom|symptoms]] include [[nausea]], [[vomiting]], [[abdominal pain]] and [[swelling]], decreased [[urination]], [[fatigue]], [[irritability]], and [[swelling]] of body. | ||
==History and Symptoms== | ==History and Symptoms== | ||
*The hallmark of HUS is | *The [[hallmark]] of [[Hemolytic-uremic syndrome|HUS]] is [[Diarrhea with blood|bloody diarrhea]] [[Dysentery|(dysentery)]].<ref>{{Cite journal | ||
| author = [[R. Bhimma]], [[N. C. Rollins]], [[H. M. Coovadia]] & [[M. Adhikari]] | | author = [[R. Bhimma]], [[N. C. Rollins]], [[H. M. Coovadia]] & [[M. Adhikari]] | ||
| title = Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal | | title = Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal | ||
| Line 18: | Line 18: | ||
| pmid = 9323280 | | pmid = 9323280 | ||
}}</ref> | }}</ref> | ||
*A positive history of | *A positive history of [[Diarrhea with blood|bloody diarrhea]] and [[Abdomen|abdominal]] [[tenderness]] is suggestive of [[HUS]]. The most common [[Symptom|symptoms]] of [[HUS]] include [[Diarrhea with blood|bloody diarrhea]] , [[fever]] and [[gastrointestinal]] complaints. The classic triad of signs/symptoms involves microangiopathic hemolytic anemia, renal failure, and thrombocytopenia. | ||
===Common Symptoms=== | ===Common Symptoms=== | ||
Symptoms of [[HUS]] include:<ref name=":0">{{Cite journal | |||
| author = [[T. G. Boyce]], [[D. L. Swerdlow]] & [[P. M. Griffin]] | | author = [[T. G. Boyce]], [[D. L. Swerdlow]] & [[P. M. Griffin]] | ||
| title = Escherichia coli O157:H7 and the hemolytic-uremic syndrome | | title = Escherichia coli O157:H7 and the hemolytic-uremic syndrome | ||
| Line 31: | Line 31: | ||
| doi = 10.1056/NEJM199508103330608 | | doi = 10.1056/NEJM199508103330608 | ||
| pmid = 7609755 | | pmid = 7609755 | ||
}}</ref><ref name="pmid9092315">{{cite journal |vauthors=Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM |title=Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features |journal=Ann. Intern. Med. |volume=126 |issue=7 |pages=505–13 |date=April 1997 |pmid=9092315 |doi= |url=}}</ref> <ref>{{Cite journal | }}</ref><ref name="pmid9092315">{{cite journal |vauthors=Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM |title=Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features |journal=Ann. Intern. Med. |volume=126 |issue=7 |pages=505–13 |date=April 1997 |pmid=9092315 |doi= |url=}}</ref><ref>{{Cite journal | ||
| author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]] | | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]] | ||
| title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome | | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome | ||
| Line 42: | Line 42: | ||
| doi = 10.1016/S0140-6736(05)71144-2 | | doi = 10.1016/S0140-6736(05)71144-2 | ||
| pmid = 15781103 | | pmid = 15781103 | ||
}}</ref> <ref>{{Cite journal | }}</ref><ref>{{Cite journal | ||
| author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]] | | author = [[Phillip I. Tarr]], [[Carrie A. Gordon]] & [[Wayne L. Chandler]] | ||
| title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome | | title = Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome | ||
| Line 53: | Line 53: | ||
| doi = 10.1016/S0140-6736(05)71144-2 | | doi = 10.1016/S0140-6736(05)71144-2 | ||
| pmid = 15781103 | | pmid = 15781103 | ||
}}</ref> <ref>{{Cite journal | }}</ref><ref>{{Cite journal | ||
| author = [[James B. Kaper]] & [[Alison D. O'Brien]] | | author = [[James B. Kaper]] & [[Alison D. O'Brien]] | ||
| title = Overview and Historical Perspectives | | title = Overview and Historical Perspectives | ||
| Line 64: | Line 64: | ||
| pmid = 25590020 | | pmid = 25590020 | ||
}}</ref> | }}</ref> | ||
* | *<nowiki/><nowiki/><nowiki/>[[Diarrhea with blood|Bloody diarrhe]]<nowiki/>[[Diarrhea with blood|a]] | ||
*Abdominal pain | *<nowiki/>[[Abdominal pain]] | ||
*Decreased urination or blood in urine | *Decreased [[urination]] or [[blood]] in [[urine]] | ||
*[[ | *[[Vomiting]] | ||
*[[ | *[[Fatigue]] | ||
*[[ | *[[Irritability]] | ||
*Abdominal [[swelling]] | *[[Abdominal]] [[swelling]] | ||
*Blood in the urine ([[hematuria]] ) | *<nowiki/>[[Blood in the urine]] ([[hematuria]]) | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of HUS include: | Less common [[symptoms]] of [[Hemolytic-uremic syndrome|HUS]] include: | ||
*[[Swollen face]] | *[[Swollen face]] | ||
*[[Swollen limbs]] | *[[Swollen face|Swollen]] [[Swollen limbs|limbs]] | ||
*[[Seizure|Seizures]] | *[[Seizure|Seizures]] | ||
Latest revision as of 00:33, 21 December 2018
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Hemolytic-uremic syndrome Microchapters |
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Differentiating Hemolytic-uremic syndrome from other Diseases |
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Hemolytic-uremic syndrome history and symptoms On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3], Anila Hussain, MD [4]
Overview
The majority of patients with hemolytic uremic syndrome (HUS) are asymptomatic. It usually start with gastrointestinal prodrome including bloody diarrhea and fever that may occur 2-7 days before the onset of renal failure. Other symptoms include nausea, vomiting, abdominal pain and swelling, decreased urination, fatigue, irritability, and swelling of body.
History and Symptoms
- The hallmark of HUS is bloody diarrhea (dysentery).[1]
- A positive history of bloody diarrhea and abdominal tenderness is suggestive of HUS. The most common symptoms of HUS include bloody diarrhea , fever and gastrointestinal complaints. The classic triad of signs/symptoms involves microangiopathic hemolytic anemia, renal failure, and thrombocytopenia.
Common Symptoms
Symptoms of HUS include:[2][3][4][5][6]
- Bloody diarrhea
- Abdominal pain
- Decreased urination or blood in urine
- Vomiting
- Fatigue
- Irritability
- Abdominal swelling
- Blood in the urine (hematuria)
Less Common Symptoms
Less common symptoms of HUS include:
References
- ↑ R. Bhimma, N. C. Rollins, H. M. Coovadia & M. Adhikari (1997). "Post-dysenteric hemolytic uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu/Natal". Pediatric nephrology (Berlin, Germany). 11 (5): 560–564. PMID 9323280. Unknown parameter
|month=ignored (help) - ↑ T. G. Boyce, D. L. Swerdlow & P. M. Griffin (1995). "Escherichia coli O157:H7 and the hemolytic-uremic syndrome". The New England journal of medicine. 333 (6): 364–368. doi:10.1056/NEJM199508103330608. PMID 7609755. Unknown parameter
|month=ignored (help) - ↑ Slutsker L, Ries AA, Greene KD, Wells JG, Hutwagner L, Griffin PM (April 1997). "Escherichia coli O157:H7 diarrhea in the United States: clinical and epidemiologic features". Ann. Intern. Med. 126 (7): 505–13. PMID 9092315.
- ↑ Phillip I. Tarr, Carrie A. Gordon & Wayne L. Chandler (2005). "Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome". Lancet (London, England). 365 (9464): 1073–1086. doi:10.1016/S0140-6736(05)71144-2. PMID 15781103. Unknown parameter
|month=ignored (help) - ↑ Phillip I. Tarr, Carrie A. Gordon & Wayne L. Chandler (2005). "Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome". Lancet (London, England). 365 (9464): 1073–1086. doi:10.1016/S0140-6736(05)71144-2. PMID 15781103. Unknown parameter
|month=ignored (help) - ↑ James B. Kaper & Alison D. O'Brien (2014). "Overview and Historical Perspectives". Microbiology spectrum. 2 (6). doi:10.1128/microbiolspec.EHEC-0028-2014. PMID 25590020. Unknown parameter
|month=ignored (help)