Thrombotic thrombocytopenic purpura historical perspective: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Thrombotic thrombocytopenic purpura}} | {{Thrombotic thrombocytopenic purpura}} | ||
{{CMG}} {{AE}} {{ | {{CMG}} {{AE}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
In 1924, Eli Moschcowitz first describe TTP. In 1960, [[plasma]] [[infusion]] was introduced as a part of the treatment of a 8-year old patient with chronic anemia and [[thrombocytopenia]] by Schulman and colleagues.In 1966, the new [[criteria]] for the [[diagnosis]] of TTP. In 1978, Upshaw first described the [[hereditary]] aspect of the [[disease]] which lacked an [[enzyme]] in the [[blood]] and responded to [[plasma]] [[transfusion]]. Moschcowitz ascribed the [[disease]]. | |||
==Historical Perspective== | ==Historical Perspective== | ||
* In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation (petechiae, anemia, and pallor followed by paralysis and coma) | * In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation ([[Petechia|petechiae]], [[anemia]], and [[pallor]] followed by [[paralysis]] and [[coma]]) <ref>{{cite journal |author=Moschcowitz E |title=An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease. |journal=Proc NY Pathol Soc |volume=24 |pages=21-4 |year=1924}} Reprinted in ''Mt Sinai J Med'' 2003;70(5):322-5, PMID 14631522.</ref>. | ||
* In 1960, plasma infusion was introduced as a part of the treatment of a 8-year old patient with chronic anemia and thrombocytopenia by Schulman and colleagues <ref name="pmid14443744">{{cite journal| author=SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z| title=Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency. | journal=Blood | year= 1960 | volume= 16 | issue= | pages= 943-57 | pmid=14443744 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14443744 }}</ref>. | * In 1960, [[plasma]] [[infusion]] was introduced as a part of the treatment of a 8-year old patient with [[Chronic (medical)|chronic]] [[anemia]] and [[thrombocytopenia]] by Schulman and colleagues <ref name="pmid14443744">{{cite journal| author=SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z| title=Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency. | journal=Blood | year= 1960 | volume= 16 | issue= | pages= 943-57 | pmid=14443744 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14443744 }}</ref>. | ||
* In 1978, Upshaw first described the hereditary aspect of the disease which lacked an enzyme in the blood and responded to plasma transfusion <ref name="Upshaw1978">{{cite journal|last1=Upshaw|first1=Jefferson D.|title=Congenital Deficiency of a Factor in Normal Plasma That Reverses Microangiopathic Hemolysis and Thrombocytopenia|journal=New England Journal of Medicine|volume=298|issue=24|year=1978|pages=1350–1352|issn=0028-4793|doi=10.1056/NEJM197806152982407}}</ref>. | * In 1966, the new [[criteria]] for the [[diagnosis]] of TTP as the “pentad” of clinical and [[laboratory]] features was suggested. The criteria included [[thrombocytopenia]], [[microangiopathic hemolytic anemia]] ([[Fragmentation (cell biology)|fragmentation]] of [[Red blood cell|RBCs]] or [[schistocytes]]) in the peripheral [[blood]] [[Smear test|smear]], [[neurological]] [[Medical sign|signs]] and [[Symptom|symptoms]], [[renal failure]], and [[fever]] . | ||
* In 1979, Rennard & Abe proposed the use of the name Upshaw-Schulman syndrome to define the disease with these clinical features who responded to plasma infusion <ref name="pmid759902">{{cite journal| author=Rennard S, Abe S| title=Decreased cold-insoluble globulin in congenital thrombocytopenia (Upshaw-Schulman syndrome) | journal=N Engl J Med | year= 1979 | volume= 300 | issue= 7 | pages= 368 | pmid=759902 | doi=10.1056/NEJM197902153000718 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=759902 }}</ref>. | * In 1978, Upshaw first described the [[hereditary]] aspect of the [[disease]] which lacked an [[enzyme]] in the [[blood]] and responded to [[plasma]] [[transfusion]] <ref name="Upshaw1978">{{cite journal|last1=Upshaw|first1=Jefferson D.|title=Congenital Deficiency of a Factor in Normal Plasma That Reverses Microangiopathic Hemolysis and Thrombocytopenia|journal=New England Journal of Medicine|volume=298|issue=24|year=1978|pages=1350–1352|issn=0028-4793|doi=10.1056/NEJM197806152982407}}</ref>. | ||
* In | * In 1979, Rennard & Abe proposed the use of the name Upshaw-Schulman [[syndrome]] to define the [[disease]] with these [[clinical]] [[Features (pattern recognition)|features]] who responded to [[plasma]] [[infusion]] <ref name="pmid759902">{{cite journal| author=Rennard S, Abe S| title=Decreased cold-insoluble globulin in congenital thrombocytopenia (Upshaw-Schulman syndrome) | journal=N Engl J Med | year= 1979 | volume= 300 | issue= 7 | pages= 368 | pmid=759902 | doi=10.1056/NEJM197902153000718 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=759902 }}</ref>. | ||
* Moschcowitz ascribed the disease (incorrectly) to a toxic cause. Moschcowitz noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi. Since that time, the pathophysiology, etiology, and medical management of TTP has expanded. | * In 1982, the [[pathogenesis]] of TTP was fully understood by Moake and colleagues <ref name="MoakeRudy1982">{{cite journal|last1=Moake|first1=Joel L.|last2=Rudy|first2=Christine K.|last3=Troll|first3=Joseph H.|last4=Weinstein|first4=Mark J.|last5=Colannino|first5=Noreen M.|last6=Azocar|first6=José|last7=Seder|first7=Richard H.|last8=Hong|first8=Suchen L.|last9=Deykin|first9=Daniel|title=Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura|journal=New England Journal of Medicine|volume=307|issue=23|year=1982|pages=1432–1435|issn=0028-4793|doi=10.1056/NEJM198212023072306}}</ref>. | ||
* | |||
* Moschcowitz ascribed the [[disease]] (incorrectly) to a [[toxic]] [[Causes|cause]]. Moschcowitz noted that his 16 year-old [[patient]] had [[anemia]]; [[petechiae]]; [[microscopic hematuria]]; and at [[autopsy]], disseminated microvascular [[thrombi]]. Since that time, the [[pathophysiology]], [[etiology]], and [[medical]] management of TTP has expanded. | |||
==References== | ==References== | ||
Latest revision as of 12:01, 14 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
In 1924, Eli Moschcowitz first describe TTP. In 1960, plasma infusion was introduced as a part of the treatment of a 8-year old patient with chronic anemia and thrombocytopenia by Schulman and colleagues.In 1966, the new criteria for the diagnosis of TTP. In 1978, Upshaw first described the hereditary aspect of the disease which lacked an enzyme in the blood and responded to plasma transfusion. Moschcowitz ascribed the disease.
Historical Perspective
- In 1924, Eli Moschcowitz first describe TTP with a pentad of presentation (petechiae, anemia, and pallor followed by paralysis and coma) [1].
- In 1960, plasma infusion was introduced as a part of the treatment of a 8-year old patient with chronic anemia and thrombocytopenia by Schulman and colleagues [2].
- In 1966, the new criteria for the diagnosis of TTP as the “pentad” of clinical and laboratory features was suggested. The criteria included thrombocytopenia, microangiopathic hemolytic anemia (fragmentation of RBCs or schistocytes) in the peripheral blood smear, neurological signs and symptoms, renal failure, and fever .
- In 1978, Upshaw first described the hereditary aspect of the disease which lacked an enzyme in the blood and responded to plasma transfusion [3].
- In 1979, Rennard & Abe proposed the use of the name Upshaw-Schulman syndrome to define the disease with these clinical features who responded to plasma infusion [4].
- In 1982, the pathogenesis of TTP was fully understood by Moake and colleagues [5].
- Moschcowitz ascribed the disease (incorrectly) to a toxic cause. Moschcowitz noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi. Since that time, the pathophysiology, etiology, and medical management of TTP has expanded.
References
- ↑ Moschcowitz E (1924). "An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease". Proc NY Pathol Soc. 24: 21–4. Reprinted in Mt Sinai J Med 2003;70(5):322-5, PMID 14631522.
- ↑ SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z (1960). "Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency". Blood. 16: 943–57. PMID 14443744.
- ↑ Upshaw, Jefferson D. (1978). "Congenital Deficiency of a Factor in Normal Plasma That Reverses Microangiopathic Hemolysis and Thrombocytopenia". New England Journal of Medicine. 298 (24): 1350–1352. doi:10.1056/NEJM197806152982407. ISSN 0028-4793.
- ↑ Rennard S, Abe S (1979). "Decreased cold-insoluble globulin in congenital thrombocytopenia (Upshaw-Schulman syndrome)". N Engl J Med. 300 (7): 368. doi:10.1056/NEJM197902153000718. PMID 759902.
- ↑ Moake, Joel L.; Rudy, Christine K.; Troll, Joseph H.; Weinstein, Mark J.; Colannino, Noreen M.; Azocar, José; Seder, Richard H.; Hong, Suchen L.; Deykin, Daniel (1982). "Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 307 (23): 1432–1435. doi:10.1056/NEJM198212023072306. ISSN 0028-4793.