Thrombotic thrombocytopenic purpura diagnostic study of choice

Thrombotic thrombocytopenic purpura Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Thrombotic thrombocytopenic purpura from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Peripheral Smear
Direct Coombs Test
von Willebrand Factor-cleaving Protease Activity
X-ray
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Thrombotic thrombocytopenic purpura diagnostic study of choice On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Thrombotic thrombocytopenic purpura diagnostic study of choice All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Thrombotic thrombocytopenic purpura diagnostic study of choice
CDC on Thrombotic thrombocytopenic purpura diagnostic study of choice
Thrombotic thrombocytopenic purpura diagnostic study of choice in the news
Blogs on Thrombotic thrombocytopenic purpura diagnostic study of choice
Directions to Hospitals Treating Thrombotic thrombocytopenic purpura
Risk calculators and risk factors for Thrombotic thrombocytopenic purpura diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2],Sogand Goudarzi, MD [3]

Study of choice

• ADAMTS13 test:

Studies that may be considered for diagnosis of the suspected cases of TTP:

• Complete blood count (CBC) with platelet count
• Review of the peripheral blood smear
• Serum electrolytes and creatinine
• Serum lactate dehydrogenase (LDH)
• Serum bilirubin level
• Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)
• Serum haptoglobin level
• Direct antiglobulin (Coombs) test (DAT)
• ADAMTS13 activity and inhibitor testing
• Stool exam
• Genetic testing for mutation in ADAMTS13 at the genomic level
• Antibodies to complement factors H and I for ruling out atypical hemolytic uremic syndrome

PLASMIC score

Platelet count (< 30,000/microL)
Hemolysis variables (Retic count > 2.5%, undetectable haptoglobin, indirect billi <2 mg/dL( >34 mcmol/L))
Absence of active cancer
Absence of transplant history (solid, stem cell)
MCV < 90 Fl
INR < 1.5
Serum creatinine < 2 mg/dL (<177 mcmol/L)

Score:

Risk of ADAMTS13 deficiency in adults with suspected TTP :

• Low-risk = 0 to 4 points
• Intermediate risk = 5 points
• High-risk = 6 to 7 points