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| == Splenomegaly differential: ==
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| {| class="wikitable"
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| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
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| ! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
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| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
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| ! colspan="12" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
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| ! colspan="10" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
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| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
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| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
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| |-
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| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
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| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
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| ! colspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
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| ! colspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
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| ! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
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| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
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| |-
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fatigue
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Weight loss
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |SOB
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |JVP
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ascites
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
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| ! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PS
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Iron
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT/PTT
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
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| ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
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| |-
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
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| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congestive
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Cirrhosis
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Heart failure
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Thrombosis of portal, hepatic, or splenic veins
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| ! rowspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Malignancy
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Lymphoma
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Leukemias
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Polycythemia Vera
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Multiple myeloma
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Essential thrombocythemia
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Primary myelofibrosis
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Primary splenic tumors
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Metastatic solid tumors
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| !Category
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| ! colspan="2" |Disease
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| !Etiology
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| !Demography
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| !History
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| !Fever
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| !Fatigue
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| !Weight loss
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| !SOB
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| !Bleeding
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| !BP
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| !JVP
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| !Jaundice
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| !Ascites
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| !Other
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| !WBC
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| !Hb
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| !Plt
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| !PS
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| !Iron
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| !LFT
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| !PT/PTT
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| !BUN/Cr
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| !UA
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| !Imaging
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| !Gold standard
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| !Associated findings
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| |-
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| ! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infection
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| ! align="center" style="background:#DCDCDC;" |Viral
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| ! align="center" style="background:#DCDCDC;" |Hepatitis, infectious mononucleosis, cytomegalovirus
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| ! align="center" style="background:#DCDCDC;" |Bacterial
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| ! align="center" style="background:#DCDCDC;" |Salmonella, Brucella, tuberculosis
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| ! rowspan="2" align="center" style="background:#DCDCDC;" |Parasitic
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| ! align="center" style="background:#DCDCDC;" |Malaria, schistosomiasis, toxoplasmosis
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| ! align="center" style="background:#DCDCDC;" |Kala-azar (visceral leishmaniasis)
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Infective endocarditis
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Fungal
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| ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inflammation
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Sarcoid
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Serum sickness
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Systemic lupus erythematosus
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Felty syndrome
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| |-
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| !Category
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| ! colspan="2" |Disease
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| !Etiology
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| !Demography
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| !History
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| !Fever
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| !Fatigue
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| !Weight loss
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| !SOB
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| !Bleeding
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| !BP
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| !JVP
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| !Jaundice
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| !Ascites
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| !Other
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| !WBC
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| !Hb
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| !Plt
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| !PS
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| !Iron
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| !LFT
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| !PT/PTT
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| !BUN/Cr
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| !UA
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| !Imaging
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| !Gold standard
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| !Associated findings
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| |-
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| ! rowspan="6" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Infiltrative
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Gaucher disease
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Niemann-Pick disease
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Amyloidosis
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Langerhans cell histiocytosis
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Hemophagocytic lymphohistiocytosis
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| |-
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Rosai-Dorfman disease
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| ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hematologic (hypersplenic) states
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Hemolytic anemia
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Sickle cell disease
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| ! colspan="2" align="center" style="background:#DCDCDC;" |Granulocyte colony-stimulating factor
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
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| ! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fatigue
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Weight loss
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |SOB
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |JVP
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ascites
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PS
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Iron
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |LFT
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT/PTT
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BUN/Cr
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
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| ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
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| |}
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