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| ==Overview== | | ==Overview== |
| Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
| | The incidence and prevalence of ALS are rising globally. More resources should be dedicated to the advancement of care and research of ALS. |
| *Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France<ref name="ALS1">{{cite journal | author = Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F | title = Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy. | journal = Ital J Neurol Sci. | volume = Apr;19 | issue = 2 | pages = 97-100 | year = 1998 | id = PMID: 10935845}}</ref><ref name="ALS2">{{cite journal | author = Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F | title = Conjugal amyotrophic lateral sclerosis: toxic clustering or change?| journal = Ital J Neurol Sci. | volume = Apr;18 | issue = 2 | pages = 109-12 | year = 1997 | id = PMID: 9239532}}</ref><ref name="ALS3">{{cite journal | author = Camu W, Cadilhac J, Billiard M. | title = Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.| journal = Neurology. | volume = Mar;44 | issue = 3 Pt 1 | pages = 547-8 | year = 1994 | id = PMID: 8145930}}</ref><ref name="ALS4">{{cite journal | author = Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. | title = Conjugal amyotrophic lateral sclerosis: report of a young married couple.| journal = Neurology.| volume = Nov;43 | issue = 11 | pages = 2378-80 | year = 1993 | id = PMID: 8232960}}</ref><ref name="9couples">{{cite journal | author = Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W | title = A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. | journal = Neurol. | volume = Apr;60 | issue = 4 | pages = 553-7 | year = 2003 | id = PMID: 12707069}}</ref>, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
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| ==Epidemiology and Demographics==
| | =Epidemiology and Demographics= |
| *Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women. | | ===Incidence=== |
| *Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France<ref name="ALS1">{{cite journal | author = Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F | title = Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy. | journal = Ital J Neurol Sci. | volume = Apr;19 | issue = 2 | pages = 97-100 | year = 1998 | id = PMID: 10935845}}</ref><ref name="ALS2">{{cite journal | author = Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F | title = Conjugal amyotrophic lateral sclerosis: toxic clustering or change?| journal = Ital J Neurol Sci. | volume = Apr;18 | issue = 2 | pages = 109-12 | year = 1997 | id = PMID: 9239532}}</ref><ref name="ALS3">{{cite journal | author = Camu W, Cadilhac J, Billiard M. | title = Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.| journal = Neurology. | volume = Mar;44 | issue = 3 Pt 1 | pages = 547-8 | year = 1994 | id = PMID: 8145930}}</ref><ref name="ALS4">{{cite journal | author = Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. | title = Conjugal amyotrophic lateral sclerosis: report of a young married couple.| journal = Neurology.| volume = Nov;43 | issue = 11 | pages = 2378-80 | year = 1993 | id = PMID: 8232960}}</ref><ref name="9couples">{{cite journal | author = Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W | title = A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. | journal = Neurol. | volume = Apr;60 | issue = 4 | pages = 553-7 | year = 2003 | id = PMID: 12707069}}</ref>, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
| | *The incidence of ALS is around 0.6-3.8 per 100000 person-years. |
| | ===Prevalance=== |
| | The prevalence of ALS is between 4.1-8.4 per 100000 person-years. |
| | ===Age Onset=== |
| | The median age of onset of ALS is between 51-66 years. |
| | ===Gender=== |
| | The male population is more commonly affected by ALS than females. |
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| | <ref name="pmid31361627">{{cite journal| author=Longinetti E, Fang F| title=Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. | journal=Curr Opin Neurol | year= 2019 | volume= 32 | issue= 5 | pages= 771-776 | pmid=31361627 | doi=10.1097/WCO.0000000000000730 | pmc=6735526 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31361627 }} </ref> |
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| ==References== | | ==References== |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
The incidence and prevalence of ALS are rising globally. More resources should be dedicated to the advancement of care and research of ALS.
Epidemiology and Demographics
Incidence
- The incidence of ALS is around 0.6-3.8 per 100000 person-years.
Prevalance
The prevalence of ALS is between 4.1-8.4 per 100000 person-years.
Age Onset
The median age of onset of ALS is between 51-66 years.
Gender
The male population is more commonly affected by ALS than females.
[1]
References
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