Amyotrophic lateral sclerosis epidemiology and demographics: Difference between revisions

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==Overview==
==Overview==
Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women. Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
The incidence and prevalence of ALS are rising globally. More resources should be dedicated to the advancement of care and research of ALS.
==Epidemiology and Demographics==
 
*Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
=Epidemiology and Demographics=
*Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France<ref name="ALS1">{{cite journal | author = Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F | title = Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy.  | journal = Ital J Neurol Sci. | volume = Apr;19 | issue = 2 | pages = 97-100 | year = 1998 | id = PMID: 10935845}}</ref><ref name="ALS2">{{cite journal | author = Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F | title = Conjugal amyotrophic lateral sclerosis: toxic clustering or change?| journal = Ital J Neurol Sci. | volume = Apr;18 | issue = 2 | pages = 109-12 | year = 1997 | id = PMID: 9239532}}</ref><ref name="ALS3">{{cite journal | author = Camu W, Cadilhac J, Billiard M.  | title = Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.| journal = Neurology.  | volume = Mar;44 | issue = 3 Pt 1 | pages = 547-8  | year = 1994 | id = PMID: 8145930}}</ref><ref name="ALS4">{{cite journal | author = Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. | title = Conjugal amyotrophic lateral sclerosis: report of a young married couple.| journal =  Neurology.| volume =  Nov;43 | issue = 11 | pages = 2378-80 | year = 1993 | id = PMID: 8232960}}</ref><ref name="9couples">{{cite journal | author = Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W | title = A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. | journal = Neurol. | volume = Apr;60 | issue = 4 | pages = 553-7 | year = 2003 | id = PMID: 12707069}}</ref>, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
===Incidence===
*The incidence of ALS is around 0.6-3.8 per 100000 person-years.
===Prevalance===
The prevalence of ALS is between 4.1-8.4 per 100000 person-years.
===Age Onset===
The median age of onset of ALS is between 51-66 years.
===Gender===
The male population is more commonly affected by ALS than females.
 
<ref name="pmid31361627">{{cite journal| author=Longinetti E, Fang F| title=Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. | journal=Curr Opin Neurol | year= 2019 | volume= 32 | issue= 5 | pages= 771-776 | pmid=31361627 | doi=10.1097/WCO.0000000000000730 | pmc=6735526 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31361627  }} </ref>


==References==
==References==

Latest revision as of 21:04, 21 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The incidence and prevalence of ALS are rising globally. More resources should be dedicated to the advancement of care and research of ALS.

Epidemiology and Demographics

Incidence

  • The incidence of ALS is around 0.6-3.8 per 100000 person-years.

Prevalance

The prevalence of ALS is between 4.1-8.4 per 100000 person-years.

Age Onset

The median age of onset of ALS is between 51-66 years.

Gender

The male population is more commonly affected by ALS than females.

[1]

References

  1. ↑ Longinetti E, Fang F (2019). "Epidemiology of amyotrophic lateral sclerosis: an update of recent literature". Curr Opin Neurol. 32 (5): 771–776. doi:10.1097/WCO.0000000000000730. PMC 6735526 Check |pmc= value (help). PMID 31361627.


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