|
|
| (14 intermediate revisions by 4 users not shown) |
| Line 12: |
Line 12: |
| }} | | }} |
| {{ID}} | | {{ID}} |
| {{CMG}}; {{AE}} {{ZAS}}, {{Akram}}, {{Anmol}} | | {{CMG}} {{shyam}}; {{AE}} {{Anmol}}, {{Akram}}, {{ZAS}} , {{Sali}}, {{Sab}} |
|
| |
|
|
| |
|
| Line 18: |
Line 18: |
| {{SK}} Immune deficiency; immunity suppression; immunological deficiency; immunosuppression | | {{SK}} Immune deficiency; immunity suppression; immunological deficiency; immunosuppression |
| ==Overview== | | ==Overview== |
| | Immunodeficiency can be caused by a variety of conditions including autoimmunity, infections, congenital defects, complement defects, or auto-inflammatory states. |
|
| |
|
| ==Classification== | | ==Classification== |
| | <div style="width: 80%; font-size: 85%;"> |
| | <small> |
| {{Family tree/start}} | | {{Family tree/start}} |
| {{Family tree| | | | | | | | | | | | | | | | | A01 | | | | | | | | |A01=Immunodeficiency}} | | {{Family tree| | | | | | | | | | | | | | | | | A01 | | | | | | | | |A01=Immunodeficiency}} |
| {{Family tree| |,|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|.| }} | | {{Family tree| |,|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|v|-|-|-|v|-|-|-|.| }} |
| {{Family tree| B01 | | B02 | | B03 | | B04 | | B05 | | B06 | | B07 | | B08 | | B09 | |B01=Immunodeficiency affecting cellular and humoral Immunity|B02=Combined immunodeficiency|B03=Predominantly antibody deficiency|B04=Diseases of immune dysregulation|B05=Congenital defects of phagocytes|B06=Defects in intrinsic and innate immunity|B07=Auto-imflammatory disorders|B08=Complement deficiencies|B09=Phenocopies of primary immunodeficiency (PID)}} | | {{Family tree| B01 | | B02 | | B03 | | B04 | | B05 | | B06 | | B07 | | B08 | | B09 | |B01=[[Immunodeficiency affecting cellular and humoral Immunity]]|B02=[[Combined immunodeficiency]]|B03=[[Predominantly antibody deficiency]]|B04=[[Diseases of immune dysregulation]]|B05=[[Congenital defects of phagocytes]]|B06=[[Defects in intrinsic and innate immunity]]|B07=[[Auto-inflammatory disorders]]|B08=[[Complement deficiencies]]|B09=[[Phenocopies of primary immunodeficiency]] (PID)}} |
| | {{Family tree|!| | | |!| | | |!| | | |!| | | |!| | | |!| | | | | | | | | | | | | | | | |}} |
| | {{Family tree|)| C01 |)| D01 |)| E01 |)| F01 |)| G01 |)| H01 | | | | | | | | | | | | | |C01=Severe combined<br>immunodeficiency (SCID)|D01=Combined immunodeficiency<br>with associated features|E01=Hypogammaglobulinemia|F01=Hemophagocytic lymphohistiocytosis (HLH)<br>& EBV susceptibility|G01=Congenital defects of<br>phagocyte number|H01=Bacterial and<br>parasitic infections}} |
| | {{Family tree|!| | | |!| | | |!| | | |!| | | |!| | | |!| | | | | | | | | | | | | | | | |}} |
| | {{Family tree|`| C02 |`| D02 |`| E02 |`| F02 |`| G02 |`| H02 | | | | | | | | | | | | | |C02=Combined immunodeficiencies<br>generally less pronounced than<br>severe combined immunodeficiency|D02=Combined immunodeficiency<br>with syndromic features|E02=Other antibody<br>deficiencies|F02= Syndromes with<br>autoimmunity and others|G02=Congenital defects of<br>phagocyte function|H02=Mendelian susceptibility to<br>mycobacterial disease (MSMD)<br>& viral infections}} |
| {{Family tree/end}} | | {{Family tree/end}} |
| | | </div> |
| ===Immunodeficiency Affecting Cellular and Humoral Immunity===
| | </small> |
| {{Family tree/start}}
| |
| {{Family tree | | | | | | | | | | A01 | | | | | | | | | | | | | | |A01=Immunodeficiency affecting cellular and humoral immunity}}
| |
| {{Family tree | | | | | |,|-|-|-|-|^|-|-|-|-|.| | | | | | | | | | |}}
| |
| {{Family tree | | | | | B01 | | | | | | | | B02 | | | | | | | | | |B01=CD19 NL: SCID T-ve B+ve|B02=CD19 ↓: SCID T-ve B-ve}}
| |
| {{Family tree | | |,|-|-|^|-|-|.| | | |,|-|-|^|-|-|.| | | | | | | |}}
| |
| {{Family tree | | C01 | | | | C02 | | C03 | | | | C04 | | | | | | |C01=SCID T-ve B+ve NK-ve|C02=SCID T-ve B+ve NK+ve|C03=SCID T-ve B-ve NK-ve|C04=SCID T-ve B-ve NK+ve}}
| |
| {{Family tree | |!| | | | | |!| | | |!| | | | | |,|^|-|-|-|.| | | |}}
| |
| {{Family tree | |)| D01 | | |)| E01 |)| F01 | | G01 | | | G02 | | |D01=yc deficiency|E01=IL7Ra .|F01=ADA def|G01=Microcephaly present|G02=Microcephaly absent}}
| |
| {{Family tree | |!| | | | | |!| | | |!| | | | |!| | | | |!| | | | |}}
| |
| {{Family tree | |`| D02 | | |)| E02 |`| F02 | |)| H01 | |)| H05 | |D02=JAK-3 def|E02=CD3D, CD3E, CD247|F02=Reticular dysgenesis|H01= DNA Ligase IV def|H05=RAG1/2 def}}
| |
| {{Family tree | | | | | | | |!| | | | | | | | |!| | | | |!| | | | |}}
| |
| {{Family tree | | | | | | | |)| E03 | | | | | |)| H02 | |`| H06 | |E03=CD45 def|H02=XLF def|H06=DCLRE1C def}}
| |
| {{Family tree | | | | | | | |!| | | | | | | | |!| | | | | | | | | |}}
| |
| {{Family tree | | | | | | | |)| E04 | | | | | |`| H03 | | | | | | |E04=Coronin-1A def|H03=DNA PKcs def}}
| |
| {{Family tree | | | | | | | |!| | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | |`| E05 | | | | | | | | | | | | | | | |E05=Winged helix def}}
| |
| {{Family tree/end}}
| |
| | |
| ===Combined Immunodeficiency===
| |
| {{Family tree/start}}
| |
| {{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | A01 | | | | | | | | | |A01=Combined Immunodeficiency Diseases with associated or syndromic features}}
| |
| {{Family tree | | | |,|-|-|-|-|-|-|v|-|-|-|-|-|v|-|-|-|-|-|v|-|-|-|-|+|-|-|-|-|v|-|-|-|-|v|-|-|-|-|v|-|-|-|-|.| |}}
| |
| {{Family tree | | | B01 | | | | | B02 | | | | B03 | | | | B04 | | | B05 | | | B06 | | | B07 | | | B08 | | | B09 | | | | | | | | | | | | | |B01=Congenital thromocytopenia|B02=DNA Repair Defects|B03=Immuno-osseous dysplasias|B04=Thymic Defects with additional congenital anomalies|B05=Hyper-IgE syndromes(HIES)|B06=Dyskeratosis congenita (DKC)|B07=Defects of Vitamin B12 and Folate metabolism|B08=Anhidrotic Ectodermodysplasia with ID|B09=Others}}
| |
| {{Family tree | | |!| | | | | | |!| | | | | |!| | | | | |!| | | | |!| | | | |!| | | | |!| | | | |!| | | | |!| | | | | | |}}
| |
| {{Family tree | | |)| C01 | | | |)| D01 | | |)| E01 | | |)| F01 | |)| G01 | |)| H01 | |)| I01 | |)| J01 | |)| K01 | | | | | | |C01=Wiskott Aldrich Syndrome|D01=Ataxia telangiectasia|E01=Cartilage Hair Hypoplasia|F01=DiDeorge Syndrome|G01=Job Syndrome|H01=Dyskeratosis congenita|I01=Transcobalmin 2 deficiency|J01=NEMO deficiency|K01=Purine nucleoside phosphorylase deficiency}}
| |
| {{Family tree | | |!| | | | | | |!| | | | | |!| | | | | |!| | | | |!| | | | |!| | | | |!| | | | |!| | | | |!| | | | | | | | }}
| |
| {{Family tree | | |)| C02 | | | |)| D02 | | |)| E02 | | |)| F02 | |)| G02 | |)| H02 | |)| I02 | |`| J02 | |)| K02 | | | | | | | |C02=XL thrombocytopenia|D02=Nijmegen breakage Syndrome|E02=Schimke Syndrome|F02=TBX1 deficiency|G02=Comel Netherton Syndrome|H02= COATS plus syndrome|I02=Deficiency causing hereditary folate malabsorption|J02=EDA-ID due to IKBA GOF mutation|K02=ID with multiple intestinal atresias}}
| |
| {{Family tree | | |!| | | | | | |!| | | | | |!| | | | | |!| | | | |!| | | | |!| | | | |!| | | | | | | | | |!| | | | | | | | | }}
| |
| {{Family tree | | |)| C03 | | | |)| D03 | | |)| E03 | | |)| F03 | |`| G03 | |)| H03 | |`| I03 | | | | | | |)| K03 | | | | | | | | |C03=WIP deficiency|D03=Bloom syndrome|E03=MYSM1 deficiency|F03=Chromosome 10p13-p14 deletion Syndrome|G03=PGM3 deficiency|H03=SAMD9|I03=Methylene-tetrahydrofolate-dehydrogenase 1 deficiency|K03=Hepatic veno-occlusive disease with immunodeficiency}}
| |
| {{Family tree | | |!| | | | | | |!| | | | | |!| | | | | |!| | | | | | | | | |!| | | | | | | | | | | | | | |!| | | | | | | | | | | }}
| |
| {{Family tree | | |`| C04 | | | |)| D04 | | |)| E04 | | |`| F04 | | | | | | |`| H04 | | | | | | | | | | | |)| K04 | | | | | | | | | |C04=ARPC1B deficiency|D04=PMS2 deficiency|E04=MOPD1 deficiency|H04=SAMD9L|K04=Vici Syndrome}}
| |
| {{Family tree | | | | | | | | | |!| | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D05 | | |`| E05 | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| K05| | | | | | |D05=Immunodeficiency with centromeric instability and facial anomalies(ICF1, ICF2, ICF3, ICF4)|E05=EXTL3 deficiency|K05=HOIL1 deficiency, HOIP1 deficiency}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D06 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| K06 | | | | |D06=MCM4 deficiency|K06=Calcium Channel Defects(ORAI-1 deficiency, STIM1 deficiency)}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D07 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| K07 | | | | | | |D07=RNF168 deficiency|K07=Hennekam-lymphangiectasia-lymphedema syndrome}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D08 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |)| K08 | | | | | | |D08=POLE1 deficiency|K08=STAT5b deficiency}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |!| | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D09 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |`| K09 | | | | | | |D09=POLE2 deficiency|K09=Kabuki Syndrome}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D10 | | | | | | | | | | | | | | | | | | | | | | | |D10=NSMCE3 deficiency}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D11 | | | | | | | | | | | | | | | | | | | | | | | |D11=ERCC6L2(Hebo deficiency)}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |)| D12 | | | | | | | | | | | | | | | | | | | | | | | |D12=Ligase 1 deficiency}}
| |
| {{Family tree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | |`| D13 | | | | | | | | | | | | | | | | | | | | | | | |D13=GINS1 deficiency}}
| |
| {{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree/end}}
| |
| | |
| ===Predominantly Antibody Deficiency===
| |
| ====Hypogammaglobulinemia====
| |
| {{Family tree/start}}
| |
| {{Family tree | | | | | | | A01 | | |A01=Predominantly Antibody deficiencies, a: Hypogammaglobulinemia}}
| |
| {{Family tree | | | | | | | |!| | | |}}
| |
| {{Family tree | | | | | | | B01 | | |B01=Serum immunoglobulin assays : IgG, IgA, IgM, IgE}}
| |
| {{Family tree | | | | | | | |!| | | |}}
| |
| {{Family tree | | | | | | | C01 | |C01=IgG, IgA, and/or IgM ↓↓
| |
| → B Lymphocyte (CD19+) enumeration (CMF)}}
| |
| {{Family tree | | |,|-|-|-|-|^|-|-|.| |}}
| |
| {{Family tree | | D01 | | | | | | D02 | |D01=B absent|D02= B >1%}}
| |
| {{Family tree | |!| | | | | |,|-|-|^|-|-|.| | |}}
| |
| {{Family tree | |)| E01 | | F01 | | | | G01 | |E01=X-Linked Agammaglobulinemia|F01=Common Variable Immunodeficiency Phenotype|G01=CD19 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |)| E02 | |)| F02 | | G02 | |E02=µ heavy chain Def|F02=CVID with no gene defect specified|G02=CD20 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |)| E03 | |)| F03 | | G03 | |E03=Igα def|F03=PIK3CD mutation(GOF),PIK3R1 deficiency(LOF)|G03=CD21 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| |}}
| |
| {{Family tree | |)| E04 | |)| F04 | | G04 | | |E04=Igβ def|F04=PTEN deficiency(LOF)|G04=TRNT1 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |)| E05 | |)| F05 | | G05 | |E05=BLNK def|F05=CD81 deficiency|G05=NFKB1 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |)| E06 | |)| F06 | | G06 | | |E06=λ5 def|F06=TACI deficiency|G06=NFKB2 deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |)| E07 | |)| F07 | | G07 | |E07=PI3KR1 def|F07=BAFF receptor deficiency|G07=IKAROS deficiency}}
| |
| {{Family tree | |!| | | | |!| | | | | |!| | |}}
| |
| {{Family tree | |`| E08 | |)| F08 | | G08 | |E08=E47 transcription factor def|F08=TWEAK deficiency|G08=ATP6AP1 deficiency}}
| |
| {{Family tree | | | | | | |!| | | |}}
| |
| {{Family tree | | | | | | |)| F09 | |F09=Mannosyl-oligosaccharide glucosidase deficiency (MOGS)}}
| |
| {{Family tree | | | | | | |!| | | | |}}
| |
| {{Family tree | | | | | | |)| F10 | | |F10=TTC37 deficiency}}
| |
| {{Family tree | | | | | | |!| | |}}
| |
| {{Family tree | | | | | | |`| F11 | | |F11=IRF2BP2 deficiency}}
| |
| {{Family tree | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree/end}}
| |
| | |
| ====Other Antibody deficiencies====
| |
| | |
| {{Family tree/start}}
| |
| {{Family tree | | | | | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | |A01=Predominantly Antibody deficiencies. b:Other antibody deficiencies}}
| |
| {{Family tree | | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | | B01 | | | | | | | | | | | | | | | | | |B01=Serum Immunolobulin Assays: IgG, IgA, IgM, IgE}}
| |
| {{Family tree | | | | | | | | | |,|-|-|-|-|-|-|+|-|-|-|-|-|.| | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | C01 | | | | | C02 | | | | C03 | | | | | | | | | | | | | | | |C01=Severe Reduction in Serum IgG and IgA with NI/elevated IgM and Normal Numbers of B cells: Hyper IgM Syndromes|C02=Isotype, Light Chain, or Functional Deficiencies with Generally NI Numbers of B cells|C03=High B cell numbers due to constitutive NF-kB activation}}
| |
| {{Family tree | | | | | | | | |!| | | | | | |!| | | | | |!| | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | |)| D01 | | | |)| D02 | | |`| D03 | | | | | | | | | | |D01=AID deficiency|D02=Selective IgA deficiency|D03=CARD11 Gain of Function}}
| |
| {{Family tree | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | |)| E01 | | | |)| E02 | | | | | | | | | | | | | | | | |E01=UNG deficiency|E02=Transient hypogammaglobuliemia of infancy}}
| |
| {{Family tree | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | |)| F01 | | | |)| F02 | | | | | | | | | | | | | | | | |F01=INO80|F02=IgG subclass deficiency with IgA deficiency}}
| |
| {{Family tree | | | | | | | | |!| | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | |`| G01 | | | |)| G02 | | | | | | | | | | | | | | | | |G01=MSH6|G02=Isolated IgG subclass deficiency}}
| |
| {{Family tree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | |)| F03 | | | | | | | | | | | | | | | | |F03=Specific antibody deficiency with normal Ig levels and normal B cells}}
| |
| {{Family tree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | |)| G03 | | | | | | | | | | | | | | | |G03=Ig heavy chain muations and deletions}}
| |
| {{Family tree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | |)| H03 | | | | | | | | | | | | | | | |H03= Kappa chain deficiency}}
| |
| {{Family tree | | | | | | | | | | | | | | | |!| | | | | | | | | | | | | | | | | |}}
| |
| {{Family tree | | | | | | | | | | | | | | | |`| I03 | | | | | | | | | | | | | | | |I03=Selective IgM deficiency}}
| |
| {{Family tree/end}}
| |
| | |
| ===Diseases of Immune Dysregulation===
| |
| | |
| ===Congenital Defects of Phagocytes===
| |
| | |
| ===Defects in Intrinsic and Innate Immunity===
| |
| | |
| ===Auto-imflammatory Disorders===
| |
| | |
| ===Complement Deficiencies===
| |
| | |
| ===Phenocopies of Primary Immunodeficiency (PID)===
| |
| {{Family tree/start}}
| |
| {{Family tree | | | | | A01 | | | | |A01=Phenocopies of PID}}
| |
| {{Family tree | | |,|-|-|^|-|-|.| | |}}
| |
| {{Family tree | | B01 | | | | | B02 | | |B01=Associated with Somatic Mutations|B02=Associated with Auto-Antibodies}}
| |
| {{Family tree | |!| | | | | | |!| | | | |}}
| |
| {{Family tree | |)| C01 | | | |)| D01 | |C01=ALPS-SFAS|D01=Chronic mucocutaneous candidiasis}}
| |
| {{Family tree | |!| | | | | | |!| | | | |}}
| |
| {{Family tree | |)| C02 | | | |)| D02 | |C02=RALD(RAS-associated autoimmune leukoproliferative disease)|D02=Adult-onset immunodeficiency with susceptibility to mycobacteria}}
| |
| {{Family tree | |!| | | | | | |!| | | | |}}
| |
| {{Family tree | |)| C03 | | | |)| D03 | |C03=Cryopyrinopathy(Muckle-Wells Syndrome)|D03=Recurrentt skin infections}}
| |
| {{Family tree | |!| | | | | | |!| | | | | |}}
| |
| {{Family tree | |`| C04 | | | |)| D04 | | |C04=Hypereosinophilic syndrome due to somatic mutations in STAT5b|D04=Pulmonary alveolar proteinosis}}
| |
| {{Family tree | | | | | | | | |!| | | | | |}}
| |
| {{Family tree | | | | | | | | |)| D05 | | |D05=Acquired angiooedema}}
| |
| {{Family tree | | | | | | | | |!| | | | | |}}
| |
| {{Family tree | | | | | | | | |)| D06 | | |D06=Atypical Hemolytic Uremic Syndrome}}
| |
| {{Family tree | | | | | | | | |!| | | | | |}}
| |
| {{Family tree | | | | | | | | |`| D07 | | |D07=Thymoma with hypogammaglobulinemia}}
| |
| {{Family tree/end}}
| |
| | |
| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
|
| |
|
|
| |
| [[Category:Immune system disorders]]
| |
| [[Category:Immunodeficiency| ]]
| |
| [[Category:Hematology]] | | [[Category:Hematology]] |
| | | [[Category:Medicine]] |
| [[ca:Immunodeficiència]] | | [[Category:Immunology]] |
| [[de:Immundefekt]] | | [[Category:Up-To-Date]] |
| [[el:Ανοσολογική ανεπάρκεια]]
| |
| [[es:Inmunodeficiencia]]
| |
| [[fr:Immunodépression]]
| |
| [[he:כשל חיסוני]]
| |
| [[pt:Imunodeficiência]]
| |
| | |
| {{WH}}
| |
| {{WS}}
| |
| | |
| [[Category:Disease]] | |