Adult T-cell leukemia classification: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Adult T-cell leukemia}} | {{Adult T-cell leukemia}} | ||
{{CMG}} {{AE}} {{HL}} | {{CMG}}; {{AE}} {{HL}}, {{AIDA}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
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==Classification== | ==Classification== | ||
* Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, | * Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, smoldering variant, or an adult T-cell [[lymphoma]] variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | ||
* The table below lists the adult T-cell leukemia clinical classification details: | * The table below lists the adult T-cell leukemia clinical classification details: | ||
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! style="background: #4479BA; width: 600px; color: #FFFFFF;" |Description | ! style="background: #4479BA; width: 600px; color: #FFFFFF;" |Description | ||
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! | ! style="background:#DCDCDC;" align="center" |Acute adult T-cell leukemia<ref name="pmid19064971">{{cite journal |vauthors=Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T |title=Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting |journal=J. Clin. Oncol. |volume=27 |issue=3 |pages=453–9 |date=January 2009 |pmid=19064971 |pmc=2737379 |doi=10.1200/JCO.2008.18.2428 |url=}}</ref> | ||
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* Leukemic clinical presentation | * Leukemic clinical presentation | ||
* [[Organomegaly]] present | * [[Organomegaly]] present | ||
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* [[Hypercalcaemia]] | * [[Hypercalcaemia]] | ||
|- | |- | ||
! | ! style="background:#DCDCDC;" align="center" |Chronic adult T-cell leukemia | ||
| | | style="background:#F5F5F5;" align="left" | | ||
* [[Lymphocyte]] count greater than 4×10<sup>9</sup>/L | * [[Lymphocyte]] count greater than 4×10<sup>9</sup>/L | ||
* [[Cutaneous]], [[pulmonary]], and [[hepatic]] involvement | * [[Cutaneous]], [[pulmonary]], and [[hepatic]] involvement | ||
| Line 29: | Line 29: | ||
* Normal [[serum]] [[calcium]] level | * Normal [[serum]] [[calcium]] level | ||
|- | |- | ||
! align="center" style="background:#DCDCDC;" |Smoldering adult T-cell leukemia | ! style="background:#DCDCDC;" align="center" |Primary cutaneous tumoral (PCT) | ||
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* [[Cutaneous]] involvement; nodules on the skin | |||
* Poor prognosis. | |||
* Normal [[serum]] [[LDH]] level (or less that twice the normal upper limit) | |||
* Normal [[serum]] [[calcium]] level | |||
|- | |||
! style="background:#DCDCDC;" align="center" |Smoldering adult T-cell leukemia<ref name="pmid18042693">{{cite journal |vauthors=Matutes E |title=Adult T-cell leukaemia/lymphoma |journal=J. Clin. Pathol. |volume=60 |issue=12 |pages=1373–7 |date=December 2007 |pmid=18042693 |pmc=2095573 |doi=10.1136/jcp.2007.052456 |url=}}</ref> | |||
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* [[Cutaneous]] and/or [[pulmonary]] infiltrates | * [[Cutaneous]] and/or [[pulmonary]] infiltrates | ||
* No other organ involvement | * No other organ involvement | ||
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* Normal serum [[calcium]] level | * Normal serum [[calcium]] level | ||
|- | |- | ||
! | ! style="background:#DCDCDC;" align="center" |Adult T-cell lymphoma<ref name="pmid27925051">{{cite journal |vauthors=Oliveira PD, Farre L, Bittencourt AL |title=Adult T-cell leukemia/lymphoma |journal=Rev Assoc Med Bras (1992) |volume=62 |issue=7 |pages=691–700 |date=October 2016 |pmid=27925051 |doi=10.1590/1806-9282.62.07.691 |url=}}</ref> | ||
| style="background:#F5F5F5;" align="left" | | |||
* [[Organomegaly]] present | * [[Organomegaly]] present | ||
* Less than 1% leukemic cells in the [[circulation]] | * Less than 1% leukemic cells in the [[circulation]] | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Medicine]] | [[Category:Medicine]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
[[Category:Infectious disease]] | |||
[[Category:Oncology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 20:18, 29 July 2020
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Adult T-cell leukemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Adult T-cell leukemia classification On the Web |
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American Roentgen Ray Society Images of Adult T-cell leukemia classification |
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Risk calculators and risk factors for Adult T-cell leukemia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2], Aida Javanbakht, M.D.; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.
Classification
- Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.[1][2]
- The table below lists the adult T-cell leukemia clinical classification details:
| Clinical Variant | Description |
|---|---|
| Acute adult T-cell leukemia[3] |
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| Chronic adult T-cell leukemia |
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| Primary cutaneous tumoral (PCT) | |
| Smoldering adult T-cell leukemia[1] |
|
| Adult T-cell lymphoma[4] |
|
References
- ↑ 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
- ↑ Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
- ↑ Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T (January 2009). "Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting". J. Clin. Oncol. 27 (3): 453–9. doi:10.1200/JCO.2008.18.2428. PMC 2737379. PMID 19064971.
- ↑ Oliveira PD, Farre L, Bittencourt AL (October 2016). "Adult T-cell leukemia/lymphoma". Rev Assoc Med Bras (1992). 62 (7): 691–700. doi:10.1590/1806-9282.62.07.691. PMID 27925051.