Macrocytic anemia diagnostic study of choice: Difference between revisions
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{{Macrocytic anemia}} | {{Macrocytic anemia}} | ||
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==Overview== | ==Overview== | ||
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==Diagnostic study of choice== | ==Diagnostic study of choice== | ||
[[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation. Both serum [[homocysteine]] and [[methylmalonic acid]] (MMA) levels are increased in helpful confirmatory tests for [[cobalamin]] and [[folate]] deficiencies. [[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency. <ref name="pmid19202968">{{cite journal |vauthors=Kaferle J, Strzoda CE |title=Evaluation of macrocytosis |journal=Am Fam Physician |volume=79 |issue=3 |pages=203–8 |date=February 2009 |pmid=19202968 |doi= |url=}}</ref><ref name="pmid23423840">{{cite journal |vauthors=Oberley MJ, Yang DT |title=Laboratory testing for cobalamin deficiency in megaloblastic anemia |journal=Am. J. Hematol. |volume=88 |issue=6 |pages=522–6 |date=June 2013 |pmid=23423840 |doi=10.1002/ajh.23421 |url=}}</ref><ref name="pmid23301732">{{cite journal |vauthors=Stabler SP |title=Clinical practice. Vitamin B12 deficiency |journal=N. Engl. J. Med. |volume=368 |issue=2 |pages=149–60 |date=January 2013 |pmid=23301732 |doi=10.1056/NEJMcp1113996 |url=}}</ref> | [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation. Both serum [[homocysteine]] and [[methylmalonic acid]] (MMA) levels are increased in helpful confirmatory tests for [[cobalamin]] and [[folate]] deficiencies. [[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency. <ref name="pmid19202968">{{cite journal |vauthors=Kaferle J, Strzoda CE |title=Evaluation of macrocytosis |journal=Am Fam Physician |volume=79 |issue=3 |pages=203–8 |date=February 2009 |pmid=19202968 |doi= |url=}}</ref><ref name="pmid23423840">{{cite journal |vauthors=Oberley MJ, Yang DT |title=Laboratory testing for cobalamin deficiency in megaloblastic anemia |journal=Am. J. Hematol. |volume=88 |issue=6 |pages=522–6 |date=June 2013 |pmid=23423840 |doi=10.1002/ajh.23421 |url=}}</ref><ref name="pmid23301732">{{cite journal |vauthors=Stabler SP |title=Clinical practice. Vitamin B12 deficiency |journal=N. Engl. J. Med. |volume=368 |issue=2 |pages=149–60 |date=January 2013 |pmid=23301732 |doi=10.1056/NEJMcp1113996 |url=}}</ref> [[Methylmalonic acid]] is increased in [[vitamin B12]] deficiency. | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]
Overview
Homocysteine and methylmalonic acid levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not methylmalonic acid is increased in folate deficiency.
Diagnostic study of choice
Homocysteine and methylmalonic acid levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not methylmalonic acid is increased in folate deficiency. [1][2][3] Methylmalonic acid is increased in vitamin B12 deficiency.
References
- ↑ Kaferle J, Strzoda CE (February 2009). "Evaluation of macrocytosis". Am Fam Physician. 79 (3): 203–8. PMID 19202968.
- ↑ Oberley MJ, Yang DT (June 2013). "Laboratory testing for cobalamin deficiency in megaloblastic anemia". Am. J. Hematol. 88 (6): 522–6. doi:10.1002/ajh.23421. PMID 23423840.
- ↑ Stabler SP (January 2013). "Clinical practice. Vitamin B12 deficiency". N. Engl. J. Med. 368 (2): 149–60. doi:10.1056/NEJMcp1113996. PMID 23301732.