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==Overview==
 
==Historical Perspective==
==Historical Perspective==


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* Common complications of optic neuritis include:<ref name="pmid3178158">{{cite journal |vauthors=Marechal F, Berthiot G, Deltour G |title=Serum levels of CA-50, CA-19.9, CA-125, CA-15.3, enolase and carcino-embryonic antigen in non neoplastic diseases of the lung |journal=Anticancer Res. |volume=8 |issue=4 |pages=677–80 |date=1988 |pmid=3178158 |doi= |url=}}</ref><ref name="pmid80680">{{cite journal |vauthors= |title=Henry Edmund Seiler |journal=Lancet |volume=2 |issue=8092 Pt 1 |pages=747 |date=September 1978 |pmid=80680 |doi= |url=}}</ref>
* Common complications of optic neuritis include:<ref name="pmid3178158">{{cite journal |vauthors=Marechal F, Berthiot G, Deltour G |title=Serum levels of CA-50, CA-19.9, CA-125, CA-15.3, enolase and carcino-embryonic antigen in non neoplastic diseases of the lung |journal=Anticancer Res. |volume=8 |issue=4 |pages=677–80 |date=1988 |pmid=3178158 |doi= |url=}}</ref><ref name="pmid80680">{{cite journal |vauthors= |title=Henry Edmund Seiler |journal=Lancet |volume=2 |issue=8092 Pt 1 |pages=747 |date=September 1978 |pmid=80680 |doi= |url=}}</ref>
**Side effects of [[corticosteroids]] use
**Side effects of [[corticosteroids]] use
**Permanent optic nerve damage
**Permanent [[optic nerve]] damage
**Decreased visual acuity
**Decreased [[visual acuity]]
***In some cases of optic neuritis, partial loss of color discrimination might persist.
***In some cases of optic neuritis, partial loss of color discrimination might persist.


Line 154: Line 151:
#[[Visual loss]]
#[[Visual loss]]
#Periocular pain
#Periocular pain
#Dyschromatopsia
#[[Dyschromatopsia]]
MRI is the diagnosis study of choice for visualising the [[optic nerve]].
[[MRI]] is the diagnosis study of choice for visualising the [[optic nerve]].


The following result of MRI is confirmatory of optic neuritis:
The following result of MRI is confirmatory of optic neuritis:
Line 167: Line 164:


===Symptoms===
===Symptoms===
* The symptoms of optic neuritis usually develop in the second decade of life, and start with symptoms such as pain on movement of the eyes, followed by a worsening of [[vision]].<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref>
* Common symptoms of optic neuritis include:<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref><ref name="pmid1734247">{{cite journal |vauthors=Beck RW, Cleary PA, Anderson MM, Keltner JL, Shults WT, Kaufman DI, Buckley EG, Corbett JJ, Kupersmith MJ, Miller NR |title=A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group |journal=N. Engl. J. Med. |volume=326 |issue=9 |pages=581–8 |date=February 1992 |pmid=1734247 |doi=10.1056/NEJM199202273260901 |url=}}</ref><ref name="pmid26396053">{{cite journal |vauthors=Wilhelm H, Schabet M |title=The Diagnosis and Treatment of Optic Neuritis |journal=Dtsch Arztebl Int |volume=112 |issue=37 |pages=616–25; quiz 626 |date=September 2015 |pmid=26396053 |pmc=4581115 |doi=10.3238/arztebl.2015.0616 |url=}}</ref>
*# Pain on movement of the eyes which is sever and so disturbing
*# Seeing things darkly, unclearly, and with [[Contrast|poor contrast]]
*# Dirty and pale Colors
*# [[Visual field loss]]
*# Disturbed [[color vision]]
*# Flashing lights
* After a sub acute onset, the patient’s [[visual acuity]] continues to deteriorate for a few more days; in the untreated course of the disease, it generally reaches its nadir in one to two weeks and then improves again.<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref>
===Physical Examination===
===Physical Examination===
Physical examination of patients with optic neuritis is usually remarkable for:<ref name="pmid3414716">{{cite journal |vauthors=Kliethermes MA |title=Working parents in two-pharmacist marriages |journal=Am J Hosp Pharm |volume=45 |issue=7 |pages=1500 |date=July 1988 |pmid=3414716 |doi= |url=}}</ref><ref name="pmid19878630">{{cite journal |vauthors=Shams PN, Plant GT |title=Optic neuritis: a review |journal=Int MS J |volume=16 |issue=3 |pages=82–9 |date=September 2009 |pmid=19878630 |doi= |url=}}</ref><ref name="pmid16554529">{{cite journal |vauthors=Balcer LJ |title=Clinical practice. Optic neuritis |journal=N. Engl. J. Med. |volume=354 |issue=12 |pages=1273–80 |date=March 2006 |pmid=16554529 |doi=10.1056/NEJMcp053247 |url=}}</ref>
* Ophthalmic examination findings:
** [[Papillitis]] with swollen [[optic disc]]
** Normal [[optic disc]] appearance (2/3 of cases) in retrobulbar neuritis type of optic neuritis
** Perineuritis, which involves the [[optic nerve]] sheath while the optic disc may or may not be swollen
** Neuroretinitis with [[Optic disc|optic disc oedema]] and macular star exudates
* Unilateral loss of [[visual acuity]]
* Reduced contrast sensitivity
* Ipsilateral relative afferent pupillary defect
* [[Visual field]] defect
* [[Color blindness|Dyschromatopsia]]


===Laboratory Findings===
===Laboratory Findings===
* There are no specific diagnostic laboratory findings associated with optic neuritis.
* If [[multiple sclerosis]] is suspected, extensive laboratory testing is recommended in the neurologic guidelines.<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref><ref name="pmid5398757">{{cite journal |vauthors=Mialaret J |title=[Apropos of M. Lagrot's article entitled "Dispute" in vagotomy on selection, chemical tests and associated antrectomy] |language=French |journal=Mem Acad Chir (Paris) |volume=95 |issue=6 |pages=194–6 |date=1969 |pmid=5398757 |doi= |url=}}</ref>
* Other recommended laboratory tests for all patients with optic neuritis include:<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref><ref name="pmid1857074">{{cite journal |vauthors=Kanareĭkin KF |title=[Soviet neuropathology in the Great Patriotic War 1941-1945] |language=Russian |journal=Klin Med (Mosk) |volume=69 |issue=5 |pages=4–6 |date=May 1991 |pmid=1857074 |doi= |url=}}</ref>
** [[C-reactive protein]]
** [[Complete blood count]]
** Serum chemistry
** [[Blood sugar]]
** [[Vitamin B12|Vitamin B<sub>12</sub>]]
** [[Rheumatoid factor]]
** [[Antinuclear antibodies]]
** [[Antiphospholipid antibodies|Anti-phospholipid antibodies]]
** [[Anti-dsDNA antibody|Anti-ds-DNA antibodies]]
** [[Lupus anticoagulant]]
** Serum [[angiotensin-converting enzyme]] test
** ''[[Borrelia burgdorferi|Borrelia]]'' serology
** [[Urinalysis]]


===Imaging Findings===
===Imaging Findings===
Among all imaging studies, [[MRI]] is the diagnosis study of choice for visualising the [[optic nerve]].
The following result of [[Magnetic resonance imaging|MRI]] is confirmatory of optic neuritis:
* Swollen retrobulbar intra-orbital segment of the optic nerve with a high T2 signal. High T2 signal persists and may be permanent;
* Atrophied nerve in chronic cases
Other diagnosis studies which may help to diagnosis of optic neuritis include:<ref name="pmid4347010" /><ref name="pmid28531809" /><ref name="pmid3005938" />
* [[Functional MRI]]
* [[Multifocal visual evoked potential]]
* [[Optical coherence tomography]] (OCT)


===Other Diagnostic Studies===
===Other Diagnostic Studies===
There are no widely used other diagnosis studies for diagnosis of optic neuritis.


==Treatment==
==Treatment==
===Medical Therapy===
===Medical Therapy===
Optic neuritis requires prompt treatment.
The mainstay of treatment for optic neuritis is [[corticosteroid]] therapy and is recommended among all patients who develop optic neuritis.<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref>
Some [[pharmacologic]] medical therapies for optic neuritis include:<ref name="pmid4581115">{{cite journal |vauthors=Wilson BJ |title=12,13-Epoxytrichothecenes: potential toxic contaminants of foods |journal=Nutr. Rev. |volume=31 |issue=6 |pages=169–72 |date=June 1973 |pmid=4581115 |doi= |url=}}</ref>
# [[Prednisone|Oral prednisone]] treatment at a dose of 1 mg/kg body weight /day for 14 days
# intravenous [[methylprednisolon]]<nowiki/>e treatment at 500–1000 mg/day for 3_5 days followed by oral prednisolone (1 mg/kg BW) for 11 days
===Surgery===
===Surgery===
*In the case of [[optic canal]] compression in patients with severe optic neuritis, [[surgery]] is used to decompress the orbital compartment by exposure of the intracanalicular part of the [[optic nerve]].<ref name="pmid3721018">{{cite journal |vauthors=Cieciura L, Krakowski G |title=Ultrastructural studies on the mitochondria of the pinealocyte under conditions of persistent lighting--L24 |journal=Folia Histochem. Cytobiol. |volume=24 |issue=1 |pages=33–7 |date=1986 |pmid=3721018 |doi= |url=}}</ref>
*Modern craniomaxillofacial surgery requires detailed consideration of the diagnosis and treatment of traumatic visual pathway damage with the ultimate goal of preserving [[visual acuity]].<ref name="pmid3721018">{{cite journal |vauthors=Cieciura L, Krakowski G |title=Ultrastructural studies on the mitochondria of the pinealocyte under conditions of persistent lighting--L24 |journal=Folia Histochem. Cytobiol. |volume=24 |issue=1 |pages=33–7 |date=1986 |pmid=3721018 |doi= |url=}}</ref>
===Prevention===
===Prevention===
There are no established measures for the primary prevention of optic neuritis.


==References==
==References==

Latest revision as of 07:38, 15 March 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Mohamadmostafa Jahansouz M.D.[2], Mohsen Basiri M.D.

Historical Perspective

Discovery

Classification

Optic neuritis may be classified into atypical or typical subtypes based on its clinical features.[2]

  • Atypical optic neuritis entails clinical manifestations that deviate from classic pattern of optic neuritis features.[3]
  • Atypical features to consider include:[3]
    • Lack of pain
    • Simultaneous or near-simultaneous onset
    • Lack of response to or relapse upon tapering from corticosteroids
    • Optic neuritis due nerve head or peripapillary hemorrhages

Pathophysiology

Pathogenesis

Causes

The following autoimmune are associated with optic neuritis:[7][8][9]

Differentiating Optic Neuritis from other Diseases

Optic neuritis must be differentiated from other diseases that cause sudden eye pain and vision loss such as:[2]

  1. Leber’s Hereditary Optic Neuropathy (LHON)[2] which results from point mutations in mitochondrial DNA and subsequent mitochondrial dysfunction, causing bilateral central vision loss.[10]
  2. Nonarteritic Anterior Ischemic Optic Neuropathy (AION)[2]

Epidemiology and Demographics

Incidence

  • The incidence of optic neuritis is approximately 5 to 6.4 per 100 000 individuals in US.[7][11][12]

Age

  • Optic neuritis commonly affects patients between the ages of 15 and 49.[13]

Race

  • Optic neuritis usually affects individuals of the Caucasians race eight times more frequently than Blacks and Asians.[7][14][15][16]
  • Black populations individuals are less likely to develop optic neuritis.[7][14][15][16]

Gender

  • Women are more commonly affected by optic neuritis than men.[2]

Region

  • The incidence of optic neuritis is highest in populations located at higher latitudes such as:[7][17][18]
    • Northern United States
    • Northern and Western Europe
    • New Zealand and Southern Australia

Risk Factors

Common Risk Factors

Natural History, Complications and Prognosis

Natural History

  • The symptoms of optic neuritis usually develop in the second decade of life, and start with symptoms such as pain on movement of the eyes, followed by a worsening of vision.[28]
  • Common symptoms of optic neuritis include:[28][29]
    1. Pain on movement of the eyes which is sever and so disturbing
    2. Seeing things darkly, unclearly, and with poor contrast
    3. Dirty and pale Colors
    4. Visual field loss
    5. Disturbed color vision
    6. Flashing lights
  • After a sub acute onset, the patient’s visual acuity continues to deteriorate for a few more days; in the untreated course of the disease, it generally reaches its nadir in one to two weeks and then improves again.[28]

Complications

Prognosis

  • The long-term visual prognosis of idiopathic optic neuritis is generally good.[31]
  • More than 90% of the patients recover a visual acuity of 20/40 or better by 6 months.[31]
  • Findings associated with poor visual outcome at 6 months include:[32][31]
    • A cut-off level of vision ≤ 20/50
    • Contrast sensitivity of <1.0 log units
    • A visual field mean deviation of ≤ – 15 dB after 1 month in the Optic Neuritis Treatment Trial.
  • Despite the relatively good visual outcome, most patients show a degree of long-lasting damage to the optic nerve, such as:[31]

Diagnosis

Diagnosis studies

The diagnosis of typical optic neuritis is usually made clinically.[2]

The classic triad for diagnosis of optic neuritis consist of:[2][17][33]

  1. Visual loss
  2. Periocular pain
  3. Dyschromatopsia

MRI is the diagnosis study of choice for visualising the optic nerve.

The following result of MRI is confirmatory of optic neuritis:

  • Swollen retrobulbar intra-orbital segment of the optic nerve with a high T2 signal. High T2 signal persists and may be permanent;
  • Atrophied nerve in chronic cases

Other diagnosis studies which may help to diagnosis of optic neuritis include:[34][35][36]

Symptoms

  • The symptoms of optic neuritis usually develop in the second decade of life, and start with symptoms such as pain on movement of the eyes, followed by a worsening of vision.[28]
  • Common symptoms of optic neuritis include:[28][29][37]
    1. Pain on movement of the eyes which is sever and so disturbing
    2. Seeing things darkly, unclearly, and with poor contrast
    3. Dirty and pale Colors
    4. Visual field loss
    5. Disturbed color vision
    6. Flashing lights
  • After a sub acute onset, the patient’s visual acuity continues to deteriorate for a few more days; in the untreated course of the disease, it generally reaches its nadir in one to two weeks and then improves again.[28]

Physical Examination

Physical examination of patients with optic neuritis is usually remarkable for:[2][17][9]

Laboratory Findings

Imaging Findings

Among all imaging studies, MRI is the diagnosis study of choice for visualising the optic nerve.

The following result of MRI is confirmatory of optic neuritis:

  • Swollen retrobulbar intra-orbital segment of the optic nerve with a high T2 signal. High T2 signal persists and may be permanent;
  • Atrophied nerve in chronic cases

Other diagnosis studies which may help to diagnosis of optic neuritis include:[34][35][36]

Other Diagnostic Studies

There are no widely used other diagnosis studies for diagnosis of optic neuritis.

Treatment

Medical Therapy

Optic neuritis requires prompt treatment.

The mainstay of treatment for optic neuritis is corticosteroid therapy and is recommended among all patients who develop optic neuritis.[28]

Some pharmacologic medical therapies for optic neuritis include:[28]

  1. Oral prednisone treatment at a dose of 1 mg/kg body weight /day for 14 days
  2. intravenous methylprednisolone treatment at 500–1000 mg/day for 3_5 days followed by oral prednisolone (1 mg/kg BW) for 11 days

Surgery

  • In the case of optic canal compression in patients with severe optic neuritis, surgery is used to decompress the orbital compartment by exposure of the intracanalicular part of the optic nerve.[40]
  • Modern craniomaxillofacial surgery requires detailed consideration of the diagnosis and treatment of traumatic visual pathway damage with the ultimate goal of preserving visual acuity.[40]

Prevention

There are no established measures for the primary prevention of optic neuritis.

References

  1. ↑ 1.0 1.1 1.2 1.3 Volpe NJ (December 2001). "Optic neuritis: historical aspects". J Neuroophthalmol. 21 (4): 302–9. PMID 11756864.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Kliethermes MA (July 1988). "Working parents in two-pharmacist marriages". Am J Hosp Pharm. 45 (7): 1500. PMID 3414716.
  3. ↑ 3.0 3.1 Gaier ED, Boudreault K, Rizzo JF, Falardeau J, Cestari DM (December 2015). "Atypical Optic Neuritis". Curr Neurol Neurosci Rep. 15 (12): 76. doi:10.1007/s11910-015-0598-1. PMID 26467052.
  4. ↑ 4.0 4.1 4.2 Hoorbakht H, Bagherkashi F (2012). "Optic neuritis, its differential diagnosis and management". Open Ophthalmol J. 6: 65–72. doi:10.2174/1874364101206010065. PMC 3414716. PMID 22888383.
  5. ↑ 5.0 5.1 5.2 Toosy AT, Mason DF, Miller DH (January 2014). "Optic neuritis". Lancet Neurol. 13 (1): 83–99. doi:10.1016/S1474-4422(13)70259-X. PMID 24331795.
  6. ↑ Taniguchi S, Kawano T, Kakunaga T, Baba T (May 1986). "Differences in expression of a variant actin between low and high metastatic B16 melanoma". J. Biol. Chem. 261 (13): 6100–6. PMID 3700386.
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Marechal F, Berthiot G, Deltour G (1988). "Serum levels of CA-50, CA-19.9, CA-125, CA-15.3, enolase and carcino-embryonic antigen in non neoplastic diseases of the lung". Anticancer Res. 8 (4): 677–80. PMID 3178158.
  8. ↑ 8.0 8.1 8.2 Bourdial J (April 1969). "[Otorhinolaryngologic action in asthmatics]". Maroc Med (in French). 49 (523): 209–17. PMID 5398737.
  9. ↑ 9.0 9.1 9.2 9.3 Balcer LJ (March 2006). "Clinical practice. Optic neuritis". N. Engl. J. Med. 354 (12): 1273–80. doi:10.1056/NEJMcp053247. PMID 16554529.
  10. ↑ Fujimori H (December 1973). "[Pulmonary tuberculosis--keypoints in nursing of pregnant and puerperal patients]". Josanpu Zasshi (in Japanese). 27 (12): 40–3. PMID 4492634.
  11. ↑ Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland LT (February 1995). "Optic neuritis: a population-based study in Olmsted County, Minnesota". Neurology. 45 (2): 244–50. PMID 7854520.
  12. ↑ Percy AK, Nobrega FT, Kurland LT (February 1972). "Optic neuritis and multiple sclerosis. An epidemiologic study". Arch. Ophthalmol. 87 (2): 135–9. PMID 5057861.
  13. ↑ 13.0 13.1 Self SG, Grossman EA (September 1986). "Linear rank tests for interval-censored data with application to PCB levels in adipose tissue of transformer repair workers". Biometrics. 42 (3): 521–30. PMID 3105615.
  14. ↑ 14.0 14.1 14.2 14.3 Bhigjee AI, Moodley K, Ramkissoon K (November 2007). "Multiple sclerosis in KwaZulu Natal, South Africa: an epidemiological and clinical study". Mult. Scler. 13 (9): 1095–9. doi:10.1177/1352458507079274. PMID 17967837.
  15. ↑ 15.0 15.1 15.2 15.3 Mbonda E, Larnaout A, Maertens A, Appel B, Lowenthal A, Mbede J, Evrard P (1990). "Multiple sclerosis in a black Cameroonian woman". Acta Neurol Belg. 90 (4): 218–22. PMID 2124032.
  16. ↑ 16.0 16.1 16.2 16.3 Phillips PH, Newman NJ, Lynn MJ (February 1998). "Optic neuritis in African Americans". Arch. Neurol. 55 (2): 186–92. PMID 9482360.
  17. ↑ 17.0 17.1 17.2 Shams PN, Plant GT (September 2009). "Optic neuritis: a review". Int MS J. 16 (3): 82–9. PMID 19878630.
  18. ↑ Kurtzke JF (July 1985). "Optic neuritis or multiple sclerosis". Arch. Neurol. 42 (7): 704–10. PMID 4015470.
  19. ↑ Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Yu-Wai-Man P, Chinnery PF. PMID 20301353. Vancouver style error: initials (help); Missing or empty |title= (help)
  20. ↑ 20.0 20.1 Chan JW (September 2002). "Optic neuritis in multiple sclerosis". Ocul. Immunol. Inflamm. 10 (3): 161–86. PMID 12789593.
  21. ↑ Haslbeck M (November 1974). "[Insulin secretion after glucose loading. Studies on insulin secretion in healthy and diabetic subjects after administration of glucose]". Fortschr. Med. (in German). 92 (32): 1317–8. PMID 4457437.
  22. ↑ Sawicka-Pierko A, Obuchowska I, Mariak Z (2014). "Nutritional optic neuropathy". Klin Oczna. 116 (2): 104–10. PMID 25345287.
  23. ↑ Primicerio B (January 1971). "[Competitions for the position of sanitary personnel in hospitals]". Policlinico Prat (in Italian). 78 (2): 72–7. PMID 5546777.
  24. ↑ Dyras M, Stós B, Zemowski W (1989). "[Possibilities of combined maxillary-orthopaedic and prosthetic treatment of malocclusion in adult patients]". Protet Stomatol (in Polish). 39 (3): 134–9. PMID 2701125.
  25. ↑ Warren SA, Warren KG (August 1983). "Optic neuritis, diabetes mellitus and multiple sclerosis: a three-way association". Can. J. Ophthalmol. 18 (5): 228–32. PMID 6354403.
  26. ↑ Holmberg D, Lundkvist I, Forni L, Ivars F, Coutinho A (1985). "Absence of immunoglobulin heavy chain expression results in altered kappa/lambda light chain ratios". J. Mol. Cell. Immunol. 2 (1): 51–6. PMID 3939751.
  27. ↑ Dabholkar AS, Tewari HB (1968). "The functional significance of the presence of acid phosphatase at the nucleic-acid synthesizing sites in the nuclei of the neurons of the cephalothoracic ganglionic masses of palaemnius". Acta Neurol. Scand. 44 (5): 533–41. PMID 4177903.
  28. ↑ 28.0 28.1 28.2 28.3 28.4 28.5 28.6 28.7 28.8 28.9 Wilson BJ (June 1973). "12,13-Epoxytrichothecenes: potential toxic contaminants of foods". Nutr. Rev. 31 (6): 169–72. PMID 4581115.
  29. ↑ 29.0 29.1 Beck RW, Cleary PA, Anderson MM, Keltner JL, Shults WT, Kaufman DI, Buckley EG, Corbett JJ, Kupersmith MJ, Miller NR (February 1992). "A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group". N. Engl. J. Med. 326 (9): 581–8. doi:10.1056/NEJM199202273260901. PMID 1734247.
  30. ↑ "Henry Edmund Seiler". Lancet. 2 (8092 Pt 1): 747. September 1978. PMID 80680.
  31. ↑ 31.0 31.1 31.2 31.3 Sagalovich V, Solov'eva IP, Kunichan AD, Nemsadze MN (1987). "[Effectiveness of single and fractional administration of isoniazid in the treatment of dogs infected with isoniazid-resistant strains of Mycobacterium tuberculosis]". Probl Tuberk (in Russian) (7): 49–53. PMID 3116540. Vancouver style error: initials (help)
  32. ↑ Achiron A, Kishner I, Sarova-Pinhas I, Raz H, Faibel M, Stern Y, Lavie M, Gurevich M, Dolev M, Magalashvili D, Barak Y (October 2004). "Intravenous immunoglobulin treatment following the first demyelinating event suggestive of multiple sclerosis: a randomized, double-blind, placebo-controlled trial". Arch. Neurol. 61 (10): 1515–20. doi:10.1001/archneur.61.10.1515. PMID 15477504.
  33. ↑ Wells H (1988). "A discussion of the KDI Quik Test Drug Screen". J Anal Toxicol. 12 (2): 111. PMID 3379920.
  34. ↑ 34.0 34.1 Ishikawa Y (October 1972). "[Electronmicroscopic observations on cultured rabbit lens cells infected with herpes virus]". Nippon Ganka Gakkai Zasshi (in Japanese). 76 (10): 1213–24. PMID 4347010.
  35. ↑ 35.0 35.1 Pihl-Jensen G, Schmidt MF, Frederiksen JL (July 2017). "Multifocal visual evoked potentials in optic neuritis and multiple sclerosis: A review". Clin Neurophysiol. 128 (7): 1234–1245. doi:10.1016/j.clinph.2017.03.047. PMID 28531809.
  36. ↑ 36.0 36.1 Rao NA, Calandra AJ, Sevanian A, Bowe B, Delmage JM, Marak GE (1986). "Modulation of lens-induced uveitis by superoxide dismutase". Ophthalmic Res. 18 (1): 41–6. doi:10.1159/000265413. PMID 3005938.
  37. ↑ Wilhelm H, Schabet M (September 2015). "The Diagnosis and Treatment of Optic Neuritis". Dtsch Arztebl Int. 112 (37): 616–25, quiz 626. doi:10.3238/arztebl.2015.0616. PMC 4581115. PMID 26396053.
  38. ↑ Mialaret J (1969). "[Apropos of M. Lagrot's article entitled "Dispute" in vagotomy on selection, chemical tests and associated antrectomy]". Mem Acad Chir (Paris) (in French). 95 (6): 194–6. PMID 5398757.
  39. ↑ Kanareĭkin KF (May 1991). "[Soviet neuropathology in the Great Patriotic War 1941-1945]". Klin Med (Mosk) (in Russian). 69 (5): 4–6. PMID 1857074.
  40. ↑ 40.0 40.1 Cieciura L, Krakowski G (1986). "Ultrastructural studies on the mitochondria of the pinealocyte under conditions of persistent lighting--L24". Folia Histochem. Cytobiol. 24 (1): 33–7. PMID 3721018.


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