Multiple myeloma causes

Multiple myeloma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

Overview

The causes of multiple myeloma include sporadic mutations, such as TP53 mutation, and inherited predisposition.

Causes

Common causes

The causes of multiple myeloma include:

• Mutations in the tumor suppressor TP53 (most common)
• Sporadic mutations and genetic predisposition
• Mutations in tumor suppressors or oncogenes
• Chromosomal aberrations such as translocations can trigger the onset of malignancy and allow for uncontrolled plasma cell proliferation.

Less common causes

• Familial causes are less contributory to the development of multiple myeloma compared to sporadic causes.

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Mutations in the tumor suppressor TP53, sporadic mutations and genetic predisposition, mutations in tumor suppressors or oncogenes, chromosomal aberrations such as translocations, familial inheritance
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the multiple myeloma in alphabetical order:

• Chromosomal aberrations
• Familial inheritance
• Mutations in oncogenes
• Mutations in the tumor suppressor TP53
• Mutations in tumor suppressors
• Translocations