Scoliosis other imaging findings: Difference between revisions
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==Overview== | ==Overview== | ||
Technetium 99m bone scan and 18F-fluoride [[positron emission tomography]] (PET) scan may be helpful in the diagnosis of the cases of persistent [[back pain]] with [[scoliosis]], with negative findings on plain [[radiographs]], [[Computed tomography|CT]], and/or [[Magnetic resonance imaging|MRI]]. 68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies. | |||
==Other Imaging Findings== | ==Other Imaging Findings== | ||
* | |||
*A Tc-99 m whole-body bone scan has a high sensitivity in detecting stress fractures and most bone lesions with osteoclastic activity.<ref name="pmid20339868">{{cite journal| author=Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE| title=Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. | journal=Eur J Pediatr | year= 2010 | volume= 169 | issue= 9 | pages= 1105-11 | pmid=20339868 | doi=10.1007/s00431-010-1188-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20339868 }} </ref> | ===PET/PET CT=== | ||
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[[File:PET scan -Thoracic endplate osteomyeltisdiscitis.jpg|thumb|rightt|500px|Thoracic Endplate Osteomyeltis with discitis. [https://radiopaedia.org/articles/spondylodiscitis Source: Case courtesy of Dr Chris O'Donnell, Radiopaedia.org, rID: 18272]]] | |||
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*18F-fluoride [[positron emission tomography]] (PET) imaging may help in cases of persistent [[back pain]] with [[scoliosis]], with negative findings on plain [[Radiography|radiographs]], [[Computed tomography|CT]], and/or [[Magnetic resonance imaging|MRI]].<ref name="pmid25030392">{{cite journal| author=Grant FD| title=¹⁸F-fluoride PET and PET/CT in children and young adults. | journal=PET Clin | year= 2014 | volume= 9 | issue= 3 | pages= 287-97 | pmid=25030392 | doi=10.1016/j.cpet.2014.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25030392 }} </ref><ref name="pmid27562570">{{cite journal| author=Taniguchi Y, Takahashi M, Matsudaira K, Oka H, Momose T| title=Potential use of (18)F-FDG-PET/CT to visualize hypermetabolism associated with muscle pain in patients with adult spinal deformity: a case report. | journal=Skeletal Radiol | year= 2016 | volume= 45 | issue= 11 | pages= 1577-81 | pmid=27562570 | doi=10.1007/s00256-016-2464-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27562570 }} </ref> | |||
*Post-operatively, patients can experience post-operative [[pain]] related to incomplete bone healing or osseous [[nonunion]], hardware loosening, or [[infection]]. | |||
*[[Positron emission tomography|PET scan]] can help localize the site of abnormal bone turnover and particularly be useful when implanted orthopedic hardware limits or prevents the use of [[Computed tomography|CT]] or [[magnetic resonance imaging]] | |||
(MRI) to image the [[spine]]. | |||
*However, the presence of orthopedic hardware raises concerns about attenuation artifacts, and sites of increased 18F-fluoride uptake should be confirmed on [[Positron emission tomography|PET]] images reconstructed without attenuation correction. | |||
<br><br><br><br><br> | |||
===Bone Scan=== | |||
*A Tc-99 m whole-body [[bone scan]] has a high sensitivity in detecting [[Fractures|stress fractures]] and most bone lesions with osteoclastic activity.<ref name="pmid20339868">{{cite journal| author=Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE| title=Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate. | journal=Eur J Pediatr | year= 2010 | volume= 169 | issue= 9 | pages= 1105-11 | pmid=20339868 | doi=10.1007/s00431-010-1188-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20339868 }} </ref> | |||
===68Ga-Citrate=== | |||
*68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies, where [[infection]] has been implicated as a cause for [[scoliosis]].<ref name="pmid21078801">{{cite journal| author=Nanni C, Errani C, Boriani L, Fantini L, Ambrosini V, Boschi S et al.| title=68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results. | journal=J Nucl Med | year= 2010 | volume= 51 | issue= 12 | pages= 1932-6 | pmid=21078801 | doi=10.2967/jnumed.110.080184 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21078801 }} </ref><ref name="pmid9544359">{{cite journal| author=Hadjipavlou AG, Cesani-Vazquez F, Villaneuva-Meyer J, Mader JT, Necessary JT, Crow W et al.| title=The effectiveness of gallium citrate Ga 67 radionuclide imaging in vertebral osteomyelitis revisited. | journal=Am J Orthop (Belle Mead NJ) | year= 1998 | volume= 27 | issue= 3 | pages= 179-83 | pmid=9544359 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9544359 }} </ref> | |||
<ref name="pmid10717911">{{cite journal| author=Gratz S, Dörner J, Oestmann JW, Opitz M, Behr T, Meller J et al.| title=67Ga-citrate and 99Tcm-MDP for estimating the severity of vertebral osteomyelitis. | journal=Nucl Med Commun | year= 2000 | volume= 21 | issue= 1 | pages= 111-20 | pmid=10717911 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10717911 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 16:18, 10 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]
Overview
Technetium 99m bone scan and 18F-fluoride positron emission tomography (PET) scan may be helpful in the diagnosis of the cases of persistent back pain with scoliosis, with negative findings on plain radiographs, CT, and/or MRI. 68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies.
Other Imaging Findings
PET/PET CT
 |
- 18F-fluoride positron emission tomography (PET) imaging may help in cases of persistent back pain with scoliosis, with negative findings on plain radiographs, CT, and/or MRI.[1][2]
- Post-operatively, patients can experience post-operative pain related to incomplete bone healing or osseous nonunion, hardware loosening, or infection.
- PET scan can help localize the site of abnormal bone turnover and particularly be useful when implanted orthopedic hardware limits or prevents the use of CT or magnetic resonance imaging
(MRI) to image the spine.
- However, the presence of orthopedic hardware raises concerns about attenuation artifacts, and sites of increased 18F-fluoride uptake should be confirmed on PET images reconstructed without attenuation correction.
Bone Scan
- A Tc-99 m whole-body bone scan has a high sensitivity in detecting stress fractures and most bone lesions with osteoclastic activity.[3]
68Ga-Citrate
- 68Ga-citrate an emerging, generator-based tracer has shown promising results in pilot studies, where infection has been implicated as a cause for scoliosis.[4][5]
References
- ↑ Grant FD (2014). "¹⁸F-fluoride PET and PET/CT in children and young adults". PET Clin. 9 (3): 287–97. doi:10.1016/j.cpet.2014.03.004. PMID 25030392.
- ↑ Taniguchi Y, Takahashi M, Matsudaira K, Oka H, Momose T (2016). "Potential use of (18)F-FDG-PET/CT to visualize hypermetabolism associated with muscle pain in patients with adult spinal deformity: a case report". Skeletal Radiol. 45 (11): 1577–81. doi:10.1007/s00256-016-2464-x. PMID 27562570.
- ↑ Hospach T, Langendoerfer M, von Kalle T, Maier J, Dannecker GE (2010). "Spinal involvement in chronic recurrent multifocal osteomyelitis (CRMO) in childhood and effect of pamidronate". Eur J Pediatr. 169 (9): 1105–11. doi:10.1007/s00431-010-1188-5. PMID 20339868.
- ↑ Nanni C, Errani C, Boriani L, Fantini L, Ambrosini V, Boschi S; et al. (2010). "68Ga-citrate PET/CT for evaluating patients with infections of the bone: preliminary results". J Nucl Med. 51 (12): 1932–6. doi:10.2967/jnumed.110.080184. PMID 21078801.
- ↑ Hadjipavlou AG, Cesani-Vazquez F, Villaneuva-Meyer J, Mader JT, Necessary JT, Crow W; et al. (1998). "The effectiveness of gallium citrate Ga 67 radionuclide imaging in vertebral osteomyelitis revisited". Am J Orthop (Belle Mead NJ). 27 (3): 179–83. PMID 9544359.
- ↑ Gratz S, Dörner J, Oestmann JW, Opitz M, Behr T, Meller J; et al. (2000). "67Ga-citrate and 99Tcm-MDP for estimating the severity of vertebral osteomyelitis". Nucl Med Commun. 21 (1): 111–20. PMID 10717911.