Mycosis fungoides history and symptoms: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(41 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Cutaneous T cell lymphoma}}
{{Mycosis fungoides}}
History{{CMG}}; {{AE}}, {{AS}}
{{CMG}}; {{AE}} {{S.G.}}
 
==Overview==
==Overview==
The most common symptoms of cutaneous T cell lymphoma include [[fever]], [[weight loss]], [[skin]] [[rash]], [[night sweats]], [[itching]], [[chest pain]], [[abdominal pain]], and [[bone pain]].<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
The most common [[Symptom|symptoms]] of mycosis fungoides include [[fever]], [[weight loss]], [[skin]] [[rash]], [[night sweats]], [[itching]], [[chest pain]], [[abdominal pain]], and [[bone pain]].<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>


==History and Symptoms==
==History and Symptoms==
===History===
===History===
*The majority of patients with mycosis fungoides and Sezary syndrome are present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref>
*The majority of [[Patient|patients]] with mycosis fungoides is present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref>
**Skin patches and plaques  
**[[Skin]] patches and [[Plaque|plaques]]
*** Erythroderma observed patchy or diffuse and can be associated with cracking or fissuring of the palms and soles.
**[[Skin]] [[erythema]] with or without [[exfoliation]]
**Eczema
***[[Erythroderma]] observed patchy or [[diffuse]]<ref name="VonderheidBernengo2002" />
**Psoriasis
***[[Erythroderma]] observed with cracking or fissuring of the palms and soles.<ref name="VonderheidBernengo2002">{{cite journal|last1=Vonderheid|first1=Eric C.|last2=Bernengo|first2=Maria Grazia|last3=Burg|first3=Günter|last4=Duvic|first4=Madeleine|last5=Heald|first5=Peter|last6=Laroche|first6=Liliane|last7=Olsen|first7=Elise|last8=Pittelkow|first8=Mark|last9=Russell-Jones|first9=Robin|last10=Takigawa|first10=Masahiro|last11=Willemze|first11=Rein|title=Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas|journal=Journal of the American Academy of Dermatology|volume=46|issue=1|year=2002|pages=95–106|issn=01909622|doi=10.1067/mjd.2002.118538}}</ref>
**Other benign skin disorders
**[[Eczema]]
*Patients with advanced disease may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
**[[Psoriasis]]
*Skin lesions in the disease obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
**Other [[benign]] [[skin]] [[Disorder (medicine)|disorders]]
*[[Patient|Patients]] with advanced [[disease]] may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
*[[Skin]] [[Lesion|lesions]] in the [[disease]] obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
*[[Tumor|Tumors]]
**> 1 cm in size (depth or vertical growth)
Diagnosis criteria from the International Society for Cutaneous Lymphoma is:<ref name="FossGirardi2017" /><ref name="PimpinelliOlsen2005">{{cite journal|last1=Pimpinelli|first1=Nicola|last2=Olsen|first2=Elise A.|last3=Santucci|first3=Marco|last4=Vonderheid|first4=Eric|last5=Haeffner|first5=Andreas C.|last6=Stevens|first6=Seth|last7=Burg|first7=Guenter|last8=Cerroni|first8=Lorenzo|last9=Dreno|first9=Brigitte|last10=Glusac|first10=Earl|last11=Guitart|first11=Joan|last12=Heald|first12=Peter W.|last13=Kempf|first13=Werner|last14=Knobler|first14=Robert|last15=Lessin|first15=Stuart|last16=Sander|first16=Christian|last17=Smoller|first17=Bruce S.|last18=Telang|first18=Gladys|last19=Whittaker|first19=Sean|last20=Iwatsuki|first20=Keiji|last21=Obitz|first21=Erik|last22=Takigawa|first22=Masahiro|last23=Turner|first23=Maria L.|last24=Wood|first24=Gary S.|title=Defining early mycosis fungoides|journal=Journal of the American Academy of Dermatology|volume=53|issue=6|year=2005|pages=1053–1063|issn=01909622|doi=10.1016/j.jaad.2005.08.057}}</ref>
 
{| class="wikitable"
|+
! style="background: #4479BA; color:#FFF;" |Criteria
! style="background: #4479BA; color:#FFF;" |Major( 2pinots)
! style="background: #4479BA; color:#FFF;" |Minor(1point)
|-
|'''Persistent and/or progressive patches and plaques plus'''
|Any 2
|Any 1
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |Clinical
|-
|1. Non–sun-exposed location
|
|
|-
|2.Size/shape variation
|
|
|-
|3.Poikiloderma
|
|
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Histopathologic'''
|-
|Superficial lymphoid infiltrate plus
|Both
|Either
|-
|1. Epidermotropism
|
|
|-
|2. Atypia
|
|
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Molecular/biological'''
|-
|Clonal TCR gene rearrangement
|
|Present
|-
| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Immunopathologic'''
|-
|1. CD2, CD3, CD5 in <59% of T cells
|
|Any 1
|-
|2. CD7 in <10% of T cells
|
|
|-
| colspan="3" |3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells
|}


===Common Symptoms===
===Common Symptoms===
Line 26: Line 89:
* [[Abdominal pain]]  
* [[Abdominal pain]]  
* [[Bone pain]]
* [[Bone pain]]
===Less Common Symptoms===
Less common symptoms of [disease name] include
*[Symptom 1]
*[Symptom 2]
*[Symptom 3]


==References==
==References==

Latest revision as of 17:54, 12 February 2019

Mycosis fungoides Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Mycosis Fungoides from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

X-Ray

CT Scan

MRI

Echocardiography and Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mycosis fungoides history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Mycosis fungoides history and symptoms

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Mycosis fungoides history and symptoms

CDC on Mycosis fungoides history and symptoms

Mycosis fungoides history and symptoms in the news

Blogs on Mycosis fungoides history and symptoms

Directions to Hospitals Treating Mycosis fungoides

Risk calculators and risk factors for Mycosis fungoides history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most common symptoms of mycosis fungoides include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain.[1]

History and Symptoms

History

Diagnosis criteria from the International Society for Cutaneous Lymphoma is:[2][4]

Criteria Major( 2pinots) Minor(1point)
Persistent and/or progressive patches and plaques plus Any 2 Any 1
Clinical
1. Non–sun-exposed location
2.Size/shape variation
3.Poikiloderma
Histopathologic
Superficial lymphoid infiltrate plus Both Either
1. Epidermotropism
2. Atypia
Molecular/biological
Clonal TCR gene rearrangement Present
Immunopathologic
1. CD2, CD3, CD5 in <59% of T cells Any 1
2. CD7 in <10% of T cells
3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells

Common Symptoms

Symptoms of cutaneous T cell lymphoma include:[1]

References

  1. ↑ 1.0 1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016
  2. ↑ 2.0 2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.
  3. ↑ 3.0 3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.
  4. ↑ Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Mycosis_fungoides_history_and_symptoms&oldid=1549135"