Mycosis fungoides laboratory findings: Difference between revisions
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{{ | {{Mycosis fungoides}} | ||
{{CMG}}; {{AE}} {{S.G.}} | {{CMG}}; {{AE}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
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==Laboratory Tests== | ==Laboratory Tests== | ||
[[Medical laboratory|Laboratory]] tests for | [[Medical laboratory|Laboratory]] tests for mycosis fungoides include:<ref name="VuralAkay2018">{{cite journal|last1=Vural|first1=Seçil|last2=Akay|first2=Bengü Nisa|last3=Botsali|first3=Ayşenur|last4=Atilla|first4=Erden|last5=Parlak|first5=Nehir|last6=Okcu Heper|first6=Aylin|last7=Şanlı|first7=Hatice|title=Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis|journal=Turkish Journal of Hematology|volume=35|issue=1|year=2018|pages=35–41|issn=13007777|doi=10.4274/tjh.2016.0502}}</ref> | ||
* [[Complete blood count]] ([[Complete blood count|CBC]]) | * [[Complete blood count]] ([[Complete blood count|CBC]]) | ||
* Peripheral [[blood]] [[Smear test|smear]] | * Peripheral [[blood]] [[Smear test|smear]] | ||
Latest revision as of 07:10, 11 February 2019
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Mycosis fungoides Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Laboratory tests for cutaneous T cell lymphoma include complete blood count (CBC), blood chemistry studies, flow cytometry, immunohistochemistry, and immunophenotyping.
Laboratory Tests
Laboratory tests for mycosis fungoides include:[1]
- Complete blood count (CBC)
- Peripheral blood smear
- Atypical T-cells (Sezary cells)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) demonstrated progressive disease had undergone.
- High level lactate dehydrogenase (LDH)in andvanced disease stage patients
- Biopsy of skin ( multiple biopsies)
- A rare evaluated finding observed mono nuclear cells aggrigation by cerebriform nuclei in the epidermis surrounding langerhans cells.
- Atypical lymphocytes observed in the epidermis or superficial dermis.
- Lymph node biopsies is recommended.
- complete metabolic panel
- Flow cytometry
- Immunohistochemistry
- Immunophenotyping: Beta F1+, CD2-/+, CD3+, CD3- (CD4-positive variant), CD4+ (CD4-positive variant), CD4-, CD5-, CD7+/-, CD8+, CD8- (CD4-positive variant), Granzyme B+, and perforin+
- Loss of CD26 and CD7 expression
- PCR
- Southern blot
References
- ↑ Vural, Seçil; Akay, Bengü Nisa; Botsali, Ayşenur; Atilla, Erden; Parlak, Nehir; Okcu Heper, Aylin; Şanlı, Hatice (2018). "Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis". Turkish Journal of Hematology. 35 (1): 35–41. doi:10.4274/tjh.2016.0502. ISSN 1300-7777.