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Replaced content with "__NOTOC__ {{CMG}}; {{AE}} {{Preeti}} ==References== {{Reflist|2}} {{WH}} {{WS}} Category: (name of the system)"
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{{CMG}}; {{AE}} {{Preeti}}
{{CMG}}; {{AE}} {{Preeti}}


{|
! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Category
! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Disease
! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Etiology
! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |Mechanism
! colspan="12" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Clinical manifestations
! colspan="10" align="center" style="background:#4479BA; color: #FFFFFF;" + |Paraclinical findings
! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Gold standard
! rowspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Associated findings
|-
! colspan="9" align="center" style="background:#4479BA; color: #FFFFFF;" + |Lab findings
! rowspan="3" |Imaging
|-
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Demography
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |History
! colspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |Symptoms
! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" + |Signs
! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" + |CBC
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |PBS
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |LFT
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |PT/PTT
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Immunochemistry
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Histopathology
! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" + |Other
|-
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Inherited
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Acquired
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Constitutional symptoms
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Rash
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Abdominal pain
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Diarrhea
! align="center" style="background:#4479BA; color: #FFFFFF;" + |V/S
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Mass
! align="center" style="background:#4479BA; color: #FFFFFF;" + |LAP
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hepatosplenomegaly
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Arthritis
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Other
! align="center" style="background:#4479BA; color: #FFFFFF;" + |WBC
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Hb
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Plt
|-
! colspan="29" align="left" style="background:#4479BA; color: #FFFFFF;" + |HL
|-
! align="center" style="background:#4479BA; color: #FFFFFF;" + |
! align="center" style="background:#DCDCDC;" + |Hodgkin's Lymphoma
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! colspan="29" align="left" style="background:#4479BA; color: #FFFFFF;" + |NHL
|-
! align="center" style="background:#4479BA; color: #FFFFFF;" + |B Cell Lymphoma
! align="center" style="background:#DCDCDC;" + |Precursor B-cell lymphoblastic leukemia/lymphoma
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* Precursor B-cell Lymphoma


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==References==
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{{Reflist|2}}
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!
|[[Follicular lymphoma]]
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* Mature B-cell Lymphoma


* Reciprocal translocation t(14;18)(q32;q21)
{{WH}}
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{{WS}}
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[[Category: (name of the system)]]
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*[[Fever]]
*[[Weight loss]]
*[[Night sweats]]
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* Painless swelling in the neck, axilla, groin, thorax and abdomen
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* Central and peripheral lymphadenopathy
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* [[Seizures]]
 
*[[Chest pain]]
*[[Bone pain]]
*[[Cough]]
*[[Dyspnea]]
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!
|Mantle cell lymphoma
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* Mature B-cell Lymphoma
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!
|Diffuse large B cell lymphoma
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* Mature B-cell Lymphoma
* 8q24/''MYC'' [[translocations]]
* Hypermutated immunoglobulin genes
* Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]'' /''TTFn'', ''[[TP53]]'' genes
* Translocations involving ''c-MYC'', ''BCL6'', and ''IgH'' gene.
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* Fever
* Night sweats
* weight loss
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* Painless rapidly enlarging [[lymph nodes]]
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|↓
|↓
|Nl to ↓
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*
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====Centroblastic====
*Medium-to-large-sized [[Lymphocyte|lymphocytes]]
*Monomorphic
====Immunoblastic====
*> 90% immunoblasts
*Trapezoid shaped large lymphoid cells with significant [[basophilic]] cytoplasm
====Anaplastic:====
*Very large cells with a round, oval, or polygonal shape that may resemble Reed-Sternberg cells
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* Hypergammaglobulinemia
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!Category
|Disease
|Etiology
!Inherited
!Acquired
|Demography
|History
!Constitutional symptoms
!Rash
!Abdominal pain
!Diarrhea
!V/S
!Mass
!LAP
!Hepatosplenomegaly
!Arthritis
!Other
!WBC
!Hb
!Plt
|PBS
|LFT
|PT/PTT
|Immunochemistry
|Histopathology
|Other lab findings
|Imaging
|Gold standard
|Associated findings
|-
!
|[[Burkitt lymphoma]]
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* Mature B-cell Lymphoma
* Translocation of chromosome 8 ''[[myc]]'' locus such as:
** t(8;14)
** t(2;8)
** t(8;22)
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* [[Fever]]
* [[Night sweats]]
* Unexplained [[weight loss]]
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* [[Proptosis]]
* Jaw mass
 
* [[Abdominal mass|Abdominal masses]]
* [[Ascites]]
 
* [[Lymphadenopathy|Peripheral lymphadenopathy]]
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* [[Swollen lymph nodes]] in the neck, axilla, or groin
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* [[CD19]]
* [[CD20]],
* [[CD22]]
* [[CD10]]
* BCL6.
* BCL2 and TdT.
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:* Medium-sized (~1.5-2x the size of a RBC) with uniform size ("monotonous") -- '''key feature''' (i.e. tumor nuclei size similar to that of [[histiocytes]] or [[endothelial cells]])
:* Round nucleus
:* Small nucleoli
:* [[basophilic]] cytoplasm
:* Brisk mitotic rate and [[apoptotic]] activity
:* Cellular outline usually appears squared off
:* "Starry-sky pattern":
:** The ''stars'' in the pattern are tingible-body macrophages (macrophages containing [[apoptotic]] tumor cells)
:** The tumour cells are the ''sky''
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!
|B cell chronic lymphocytic leukemia/small lymphocytic lymphoma
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* Mature B-cell Lymphoma
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!
|Marginal zone lymphoma
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* Mature B-cell Lymphoma
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!
|Lymphoplasmacytic lymphoma (Waldenstrom’s macroglobulinemia)
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* Mature B-cell Lymphoma
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| rowspan="25" |B cell lymphoma
|[[Mantle cell lymphoma]]
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* [[CD5 (protein)|CD5]] positive antigen in pregerminal center of B-cell
* [[Chromosomal translocation]] at '''t(11:14)'''
** Over-express [[cyclin D1]]
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* Stage IV disease
* B symptoms,
* Generalized lymphadenopathy
* Abdominal distention
* Fatigue
* Night sweats
* Weight Loss
* Extranodal involvement of gastrointtestinal (GI) tract, lungs, and central nervous system (CNS)
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* Generalized lymphadenopathy
* Hepato-splenomegaly
* Mental Retardation
* Less commonly
** Palpable masses in skin, breast, and salivary glands
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|CBC
* Anemia and cytopenias are secondary to bone marrow infiltration
* Lymphocytosis > 4000/µL
* Elevated LDH
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* CD5<sup>+</sup>
* B-cell antigen positive
** CD19
** CD20
** CD22
* Cyclin D1 is overexpressed.
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* Germinal centers filled by small-to-medium atypical lymphocytes.
* Nodular appearance may be evident from expansion of the mantle zone in 30-50% of patients early in the disease.
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|[[Nodal marginal zone B-cell lymphoma]]
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* Arise from memory B cells. Include
** Splenic marginal zone lymphoma
** Nodal marginal zone lymphoma
** Extranodal marginal zone lymphoma.
* Stimulation of antigen receptor by autoantigen and co-stimulatory molecule CD40.
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* Depends largely on its location
* Gastric marginal zone lymphoma
** Dyspepsia
** Abdominal pain
** Hemorrhage
* Chronic infectious conditions or autoimmune processes, such as
** ''H pylori'' gastritis
** Hashimoto thyroiditis
** Sjögren syndrome.
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* AE1/AE3
* B-cell markers CD20, CD79a, CD10, CD23, and bcl-2 are expressed
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* Follicular cells in reactive zone
* Centrocyte like cells in marginal zone lymphoma
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|[[Splenic marginal zone lymphoma]]
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* Clonal rearrangements of the [[immunoglobulin]] genes (heavy and light chains) .
** Deletion 7q21-32
** Translocations of the CDK6 gene located at 7q21.
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* [[CD20]]
* [[CD79a]]
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* [[B-cells]] replace the normal [[white pulp]] of the [[spleen]].
* The neoplastic cells compromise
** Small [[lymphocytes]]
** Transformed blasts
* S[[Sinus|inus]] invasion
* Epithelial histocytes
* Plasmacytic differentiation of neoplastic cells.
* '''Splenic Hilar Lymph Nodes'''
** Involved hilar [[lymph nodes]] adjacent to the [[spleen]] show an effaced architecture without preservation of the [[marginal zone]] seen in the spleen
* '''Bone Marrow Biopsy'''
** Splenic marginal zone lymphoma in [[bone marrow]] displays a nodular pattern with morphology similar to what is observed in the splenic [[hilar]] [[lymph nodes]].
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|[[Hairy cell leukemia]]
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* Production of [[Cytokine|cytokines]], such as [[TNF alpha]] and IL-2R, provide important stimuli for [[malignant]] [[B cell|B cells]] proliferation in hairy cell leukemia.
** The ''p38-MAPK-JNK'' cascade
** The ''MEK-ERK'' cascade
** The ''Phosphatidylinositol 3 kinase (PI3K)-AKT'' cascade
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* [[Fever]]
* [[Night sweat|Night sweats]]
* [[Fatigue]]
* Easy [[bruising]] or [[bleeding]]
* Generalized weakness
* [[Weight loss]]
* Recurrent [[Infection|infections]]
* Early satiety
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* [[Pallor]],
* [[Petechiae]]
* [[Splenomegaly]]
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* Tartrate-resistant acid phosphatase  positive
* CBC
** Decreased [[hemoglobin]] concentration
** Decreased [[platelets]] count
**
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* [[Annexin A1]]
* [[CD20]]
* [[CD25]]
* [[CD103]]
* [[CD19]]
* [[CD11c]]
* [[FMC7]]
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:* Small cells with "fried egg"-like appearance
:* Well-demarcated thread-like [[cytoplasmic]] extensions
:* Clear cytoplasm
:* Central round [[nucleus]]
:* Peri-nuclear clearing ("water-clear rim" appearance)
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|[[Multiple myeloma|Plasma cell myeloma]]
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|[[Chronic lymphocytic leukemia]] / [[Chronic lymphocytic leukemia|small lymphocytic lymphoma]]
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|[[Monoclonal B-cell lymphocytosis]]
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|[[B-cell prolymphocytic leukemia]]
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|[[Waldenström's macroglobulinemia|Waldenström's macroglubulinemia]]
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|[[Monoclonal gammopathy of undetermined significance]] (MGUS)
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|[[Heavy chain disease]]
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|Solitary plasmacytoma of bone
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|Extraosseous plasmacytoma
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|Monoclonal immunoglobulin deposition diseases
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|Extranodal marginal zone lymphoma of [[MALT lymphoma|mucosa-associated lymphoid tissue]] (MALT lymphoma)
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|Large B-cell lymphoma with IRF4 rearrangement
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|[[Primary cutaneous follicle centre lymphoma|Primary cutaneous follicle center lymphoma]]
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|T-cell/histiocyte-rich large B-cell lymphoma
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|[[Lymphomatoid granulomatosis]]
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|[[Primary mediastinal large B-cell lymphoma|Primary mediastinal (thymic) large B-cell lymphoma]]
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|[[Intravascular large B-cell lymphoma]]
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|ALK1 large B-cell lymphoma
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|Plasmablastic lymphoma
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|[[Primary effusion lymphoma]]
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|High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements
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| rowspan="6" |T cell lymphoma
|[[Mycosis fungoides]] / [[Sézary syndrome]]
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* The [[tumor]] [[Cell (biology)|cells]] originate from [[memory T cells]] or [[skin]] homing [[CD4+ T cells]] expressing [[cutaneous]] [[lymphocyte]] [[antigen]] (CLA) and [[chemokine]] [[receptors]] [[CCR4]]<nowiki/>and CCR7.
* It is understood that cutaneous t cell lymphoma (maycosis fungoides, Sezary sydrome ) is the result of malignant T cell that derived from a mature CD41 CD45RO1 memory T cells.
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* [[Epidermis (skin)|Epidermal]] [[atrophy]] or poikiloderma
 
* Generalized [[itching]]([[pruritus]])
* [[Pain]] in the affected area of the skin.
* [[Insomnia]]
* Red ([[erythematous]]) patches scattered over the [[skin]] of the [[trunk]] and the [[extremities]]
* [[Weight loss]]
* [[Lymphadenopathy]]
* [[Malaise]] and [[fatigue]]
* [[Anemia]]
* May progress to [[Sezary syndrome]] (Skin involvement plus hematogenous dissemination)
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* Cutaneous manifestaions
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|[[T-cell granular lymphocytic leukemia]]
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* Disregulation of signaling pathways:
** FAS/FAS-L
** Phosphatidylinositol-3 kinase (PI3K),
** Mitogen-activated proteinkinase/extracellular signal-regulated kinase (MAPK/ERK)
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Symptoms of T-cell large granular lymphocyte leukemia may include the following:
* Generalised weakness and [[Fatigue (physical)|fatigue]]
* [[Anorexia]]
* Joint pain
* Night sweating
* [[Epistaxis]]
* [[Bone pain]]
* [[Dyspnea]]
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* Usually appear pale and malnourished.
* Cardiac flow murmur
* High-grade fever
* [[Hepatomegaly]]
* [[Splenomegaly]]
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* Neutropenia
* Anemia
* Hypergammaglobulinemia
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* [[CD3]]+
* [[TCR]]αβ+
* [[CD4]]-
* [[CD8]]+
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:* Clonal rearrangements of the [[T-cell receptor]] (TCR) gene
:* Chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood
:* Large granular lymphocyte count greater than 2.0 × 109/L
:* Lymphocytosis (typically 2-20x109/L)
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|[[Subcutaneous panniculitis-like T-cell lymphoma]]
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<references />

Latest revision as of 16:32, 8 March 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]


References

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