Merkel cell cancer classification: Difference between revisions
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{{Merkel cell cancer}} | {{Merkel cell cancer}} | ||
{{CMG}} {{AE}} {{ | {{CMG}} {{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
[[Merkel cell carcinoma]] is classified into 3 subgroups: trabecular, intermediate, and small cell. | [[Merkel cell carcinoma]] is classified into 3 subgroups: trabecular, intermediate, and small cell. | ||
==Classification== | ==Classification== | ||
Histologically, [[MCC]] has been classified into three distinct subtypes:<ref name="pmid3724197">{{cite journal |vauthors=Suster S, Ronnen M, Lin E, Shewach-Millet M |title=Trabecular carcinoma of the skin simulating metastatic disease |journal=J Surg Oncol |volume=32 |issue=2 |pages=73–5 |date=June 1986 |pmid=3724197 |doi= |url=}}</ref><ref name="pmid1698390">{{cite journal |vauthors=Johansson L, Tennvall J, Akerman M |title=Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature |journal=APMIS |volume=98 |issue=8 |pages=741–52 |date=August 1990 |pmid=1698390 |doi= |url=}}</ref> | Histologically, [[MCC]] has been classified into three distinct subtypes:<ref name="pmid16466578">{{cite journal |vauthors=Koljonen V |title=Merkel cell carcinoma |journal=World J Surg Oncol |volume=4 |issue= |pages=7 |date=February 2006 |pmid=16466578 |pmc=1382229 |doi=10.1186/1477-7819-4-7 |url=}}</ref><ref name="pmid3724197">{{cite journal |vauthors=Suster S, Ronnen M, Lin E, Shewach-Millet M |title=Trabecular carcinoma of the skin simulating metastatic disease |journal=J Surg Oncol |volume=32 |issue=2 |pages=73–5 |date=June 1986 |pmid=3724197 |doi= |url=}}</ref><ref name="pmid1698390">{{cite journal |vauthors=Johansson L, Tennvall J, Akerman M |title=Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature |journal=APMIS |volume=98 |issue=8 |pages=741–52 |date=August 1990 |pmid=1698390 |doi= |url=}}</ref> | ||
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|Classic pattern | |Classic pattern | ||
| | | | ||
* | * Large-cells | ||
* High density granules | * High density [[granules]] | ||
* Organoid clusters of cells | * Organoid [[Cluster (epidemiology)|clusters]] of cells | ||
* Trabeculae with ribbons | * [[Trabeculae]] with ribbons | ||
* Most commonly occurs in hair follicles | * Most commonly occurs in [[hair follicles]] | ||
|- | |- | ||
|'''Intermediate''' '''type''' | |'''Intermediate''' '''type''' | ||
|Solid pattern | |[[Solid]] pattern | ||
| | | | ||
* Most common subtype | * Most common subtype | ||
* Compactly arranged cells | * Compactly arranged cells | ||
* Cytoplasm is less abundant in the cells | * [[Cytoplasm]] is less abundant in the cells | ||
* Mitotic figures are positive | * [[Mitotic]] figures are positive | ||
* Necrosis is positive | * [[Necrosis]] is positive | ||
* Intermediate type may invade the epidermis | * Intermediate type may invade the [[Epidermis (skin)|epidermis]] | ||
* More aggressive subtype when compared to the trabecular type | * More aggressive subtype when compared to the trabecular type | ||
* | * | ||
|- | |- | ||
|'''Small cell type''' | |'''Small cell type''' | ||
|Diffuse pattern | |[[Diffuse]] pattern | ||
| | | | ||
* Few high density granules | * Few high density [[granules]] | ||
* Arises in the [[dermis]] | |||
* Sheets of solid and clusters of cells | |||
* Mimics other small cell tumours | |||
|} | |} | ||
Latest revision as of 15:35, 9 January 2019
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Risk calculators and risk factors for Merkel cell cancer classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Merkel cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.
Classification
Histologically, MCC has been classified into three distinct subtypes:[1][2][3]
| Subtype | Pattern | Histology studies |
|---|---|---|
| Trabecular type | Classic pattern |
|
| Intermediate type | Solid pattern | |
| Small cell type | Diffuse pattern |
References
- ↑ Koljonen V (February 2006). "Merkel cell carcinoma". World J Surg Oncol. 4: 7. doi:10.1186/1477-7819-4-7. PMC 1382229. PMID 16466578.
- ↑ Suster S, Ronnen M, Lin E, Shewach-Millet M (June 1986). "Trabecular carcinoma of the skin simulating metastatic disease". J Surg Oncol. 32 (2): 73–5. PMID 3724197.
- ↑ Johansson L, Tennvall J, Akerman M (August 1990). "Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature". APMIS. 98 (8): 741–52. PMID 1698390.