Burkitt's lymphoma laboratory tests: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Burkitt's lymphoma}} | {{Burkitt's lymphoma}} | ||
{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}}, {{kakbar}} | ||
==Overview== | ==Overview== | ||
Laboratory tests for Burkitt's lymphoma include [[complete blood count]] (CBC), blood chemistry studies, | Laboratory tests for Burkitt's lymphoma include [[complete blood count]] (CBC), [[Basic metabolic panel|blood chemistry]] studies, [[immunohistochemistry]], [[HIV]] blood test, [[Flow cytometry|flow cytometric]] analysis, and [[cytogenetics]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory tests for Burkitt's lymphoma include:<ref name="pmid19074108">{{cite journal| author=Perkins AS, Friedberg JW| title=Burkitt lymphoma in adults. | journal=Hematology Am Soc Hematol Educ Program | year= 2008 | volume= | issue= | pages= 341-8 | pmid=19074108 | doi=10.1182/asheducation-2008.1.341 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19074108 }} </ref> | Laboratory tests for Burkitt's lymphoma include:<ref name="pmid19074108">{{cite journal| author=Perkins AS, Friedberg JW| title=Burkitt lymphoma in adults. | journal=Hematology Am Soc Hematol Educ Program | year= 2008 | volume= | issue= | pages= 341-8 | pmid=19074108 | doi=10.1182/asheducation-2008.1.341 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19074108 }} </ref> | ||
* [[Complete blood count]]<ref name="pmid30290813">{{cite journal| author=Ekemen S, Uzay A, Bassullu N, Dikicioglu-Cetin E, Matsuda K, Ince U et al.| title=Does it take three to tango? An unsuspected multimorbidity of CD8+ T cell lymphoproliferative disorder, malaria, and EBV infection. | journal=Malar J | year= 2018 | volume= 17 | issue= 1 | pages= 349 | pmid=30290813 | doi=10.1186/s12936-018-2497-9 | pmc=6173833 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30290813 }} </ref> | * [[Complete blood count]]<ref name="pmid30290813">{{cite journal| author=Ekemen S, Uzay A, Bassullu N, Dikicioglu-Cetin E, Matsuda K, Ince U et al.| title=Does it take three to tango? An unsuspected multimorbidity of CD8+ T cell lymphoproliferative disorder, malaria, and EBV infection. | journal=Malar J | year= 2018 | volume= 17 | issue= 1 | pages= 349 | pmid=30290813 | doi=10.1186/s12936-018-2497-9 | pmc=6173833 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30290813 }} </ref> | ||
* Blood chemistry studies include: | * Blood chemistry studies include: | ||
:* [[Renal function tests]] | :* [[Renal function tests]]<ref name="pmid16619689">{{cite journal| author=Mwanda WO, Orem J, Remick SC, Rochford R, Whalen C, Wilson ML| title=Clinical characteristics of Burkitt's lymphoma from three regions in Kenya. | journal=East Afr Med J | year= 2005 | volume= 82 | issue= 9 Suppl | pages= S135-43 | pmid=16619689 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16619689 }} </ref> | ||
:* [[Liver function tests]] | :* [[Liver function tests]]<ref name="pmid16619689">{{cite journal| author=Mwanda WO, Orem J, Remick SC, Rochford R, Whalen C, Wilson ML| title=Clinical characteristics of Burkitt's lymphoma from three regions in Kenya. | journal=East Afr Med J | year= 2005 | volume= 82 | issue= 9 Suppl | pages= S135-43 | pmid=16619689 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16619689 }} </ref> | ||
* [[HIV]] blood test | * [[HIV]] blood test <ref name="pmid24551737">{{cite journal| author=Pinisetti S, Nalabolu GR, Uvr C, Tadi DP| title=HIV Associated Intra-oral Burkitt's Lymphoma: A Case Report. | journal=J Clin Diagn Res | year= 2013 | volume= 7 | issue= 12 | pages= 3088-9 | pmid=24551737 | doi=10.7860/JCDR/2013/6715.3862 | pmc=3919292 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24551737 }} </ref> | ||
* Immuno histochemistry: [[CD19]] +, [[CD20]] +, [[CD22]] +, [[CD79a]] +, Bcl-6 +, [[CD10]] +, [[CD38]] +, Mum-1 -, [[CD44]] -, [[CD138]] -, and [[Bcl-2]]- | * Immuno histochemistry: [[CD19]] +, [[CD20]] +, [[CD22]] +, [[CD79a]] +, Bcl-6 +, [[CD10]] +, [[CD38]] +, Mum-1 -, [[CD44]] -, [[CD138]] -, and [[Bcl-2]]-<ref name="pmid26437030">{{cite journal| author=Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK et al.| title=DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control. | journal=Nat Genet | year= 2015 | volume= 47 | issue= 11 | pages= 1316-1325 | pmid=26437030 | doi=10.1038/ng.3413 | pmc=5444523 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26437030 }} </ref> | ||
* Flow cytometric analysis: (immunophenotype) [[CD19]] +, [[CD20]] +, [[CD22]] +, and cytoplasmic terminal deoxynucleotidyl transferase (TdT) - | * [[Flow cytometry|Flow cytometric]] analysis: (immunophenotype) [[CD19]] +, [[CD20]] +, [[CD22]] +, and cytoplasmic terminal deoxynucleotidyl transferase (TdT) -<ref name="pmid22431545">{{cite journal| author=McGowan P, Nelles N, Wimmer J, Williams D, Wen J, Li M et al.| title=Differentiating between Burkitt lymphoma and CD10+ diffuse large B-cell lymphoma: the role of commonly used flow cytometry cell markers and the application of a multiparameter scoring system. | journal=Am J Clin Pathol | year= 2012 | volume= 137 | issue= 4 | pages= 665-70 | pmid=22431545 | doi=10.1309/AJCP3FEPX5BEEKGX | pmc=4975158 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22431545 }} </ref> | ||
* [[Cytogenetics]] include: | * [[Cytogenetics]] include: | ||
:* Giemsa banding | :* [[Banding (medical)|Giemsa banding]] | ||
:* Fluorescence in situ hybridization ([[FISH]]) | :* [[Fluorescence in situ hybridization]] ([[FISH]])<ref name="GrygalewiczWoroniecka2018">{{cite journal|last1=Grygalewicz|first1=Beata|last2=Woroniecka|first2=Renata|last3=Rymkiewicz|first3=Grzegorz|last4=Rygier|first4=Jolanta|last5=Borkowska|first5=Klaudia|last6=Kotyl|first6=Aleksandra|last7=Blachnio|first7=Katarzyna|last8=Bystydzienski|first8=Zbigniew|last9=Nowakowska|first9=Beata|last10=Pienkowska-Grela|first10=Barbara|title=The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration, as Well as MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma, NOS|journal=American Journal of Clinical Pathology|volume=149|issue=1|year=2018|pages=17–28|issn=0002-9173|doi=10.1093/ajcp/aqx139}}</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 02:25, 21 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]
Overview
Laboratory tests for Burkitt's lymphoma include complete blood count (CBC), blood chemistry studies, immunohistochemistry, HIV blood test, flow cytometric analysis, and cytogenetics.
Laboratory Findings
Laboratory tests for Burkitt's lymphoma include:[1]
- Complete blood count[2]
- Blood chemistry studies include:
- HIV blood test [4]
- Immuno histochemistry: CD19 +, CD20 +, CD22 +, CD79a +, Bcl-6 +, CD10 +, CD38 +, Mum-1 -, CD44 -, CD138 -, and Bcl-2-[5]
- Flow cytometric analysis: (immunophenotype) CD19 +, CD20 +, CD22 +, and cytoplasmic terminal deoxynucleotidyl transferase (TdT) -[6]
- Cytogenetics include:
References
- ↑ Perkins AS, Friedberg JW (2008). "Burkitt lymphoma in adults". Hematology Am Soc Hematol Educ Program: 341–8. doi:10.1182/asheducation-2008.1.341. PMID 19074108.
- ↑ Ekemen S, Uzay A, Bassullu N, Dikicioglu-Cetin E, Matsuda K, Ince U; et al. (2018). "Does it take three to tango? An unsuspected multimorbidity of CD8+ T cell lymphoproliferative disorder, malaria, and EBV infection". Malar J. 17 (1): 349. doi:10.1186/s12936-018-2497-9. PMC 6173833. PMID 30290813.
- ↑ 3.0 3.1 Mwanda WO, Orem J, Remick SC, Rochford R, Whalen C, Wilson ML (2005). "Clinical characteristics of Burkitt's lymphoma from three regions in Kenya". East Afr Med J. 82 (9 Suppl): S135–43. PMID 16619689.
- ↑ Pinisetti S, Nalabolu GR, Uvr C, Tadi DP (2013). "HIV Associated Intra-oral Burkitt's Lymphoma: A Case Report". J Clin Diagn Res. 7 (12): 3088–9. doi:10.7860/JCDR/2013/6715.3862. PMC 3919292. PMID 24551737.
- ↑ Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK; et al. (2015). "DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control". Nat Genet. 47 (11): 1316–1325. doi:10.1038/ng.3413. PMC 5444523. PMID 26437030.
- ↑ McGowan P, Nelles N, Wimmer J, Williams D, Wen J, Li M; et al. (2012). "Differentiating between Burkitt lymphoma and CD10+ diffuse large B-cell lymphoma: the role of commonly used flow cytometry cell markers and the application of a multiparameter scoring system". Am J Clin Pathol. 137 (4): 665–70. doi:10.1309/AJCP3FEPX5BEEKGX. PMC 4975158. PMID 22431545.
- ↑ Grygalewicz, Beata; Woroniecka, Renata; Rymkiewicz, Grzegorz; Rygier, Jolanta; Borkowska, Klaudia; Kotyl, Aleksandra; Blachnio, Katarzyna; Bystydzienski, Zbigniew; Nowakowska, Beata; Pienkowska-Grela, Barbara (2018). "The 11q-Gain/Loss Aberration Occurs Recurrently in MYC-Negative Burkitt-like Lymphoma With 11q Aberration, as Well as MYC-Positive Burkitt Lymphoma and MYC-Positive High-Grade B-Cell Lymphoma, NOS". American Journal of Clinical Pathology. 149 (1): 17–28. doi:10.1093/ajcp/aqx139. ISSN 0002-9173.