Hepatocellular adenoma laboratory tests: Difference between revisions
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{{CMG}};{{AE}}{{ZAS}} | {{CMG}};{{AE}}{{ZAS}} | ||
==Overview== | ==Overview== | ||
[[Patient|Patients]] suffering from hepatocellular adenoma usually have normal [[liver function tests]] and normal [[Tumor markers|serum tumor markers]]. [[Acute phase reactant|Acute phase reactants]] may be raised secondary to [[necrosis]] or [[hemorrhage]] and [[alkaline phosphatase]] may be raised in [[Hepatocyte|hepatocellular]] [[adenomatosis]]. | |||
==Laboratory Findings== | |||
*[[Patients]] suffering from hepatocellular adenoma usually have normal [[liver function tests]] with no elevation in [[Tumor markers|serum tumor markers]], such as [[Alpha-fetoprotein|alpha fetoprotein]].<ref name="DhingraFiel2014">{{cite journal|last1=Dhingra|first1=Sadhna|last2=Fiel|first2=M. Isabel|title=Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=8|year=2014|pages=1090–1097|issn=0003-9985|doi=10.5858/arpa.2013-0183-RA}}</ref><ref>{{Cite journal | |||
| author = [[Paulette Bioulac-Sage]], [[Sandra Rebouissou]], [[Antonio Sa Cunha]], [[Emmanuelle Jeannot]], [[Sebastien Lepreux]], [[Jean-Frederic Blanc]], [[Helene Blanche]], [[Brigitte Le Bail]], [[Jean Saric]], [[Pierre Laurent-Puig]], [[Charles Balabaud]] & [[Jessica Zucman-Rossi]] | |||
| title = Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver | |||
| journal = [[Gastroenterology]] | |||
| volume = 128 | |||
| issue = 5 | |||
| pages = 1211–1218 | |||
| year = 2005 | |||
| month = May | |||
| pmid = 15887105 | |||
}}</ref><ref name="NaultParadis2017">{{cite journal|last1=Nault|first1=Jean-Charles|last2=Paradis|first2=Valérie|last3=Cherqui|first3=Daniel|last4=Vilgrain|first4=Valérie|last5=Zucman-Rossi|first5=Jessica|title=Molecular classification of hepatocellular adenoma in clinical practice|journal=Journal of Hepatology|volume=67|issue=5|year=2017|pages=1074–1083|issn=01688278|doi=10.1016/j.jhep.2017.07.009}}</ref> | |||
* The [[liver function tests]] may be found abnormal secondary to [[necrosis]] or [[hemorrhage]]. | |||
*[[Alkaline phosphatase]] is raised in [[Patient|patients]] with [[Hepatocyte|hepatocellular]] [[adenomatosis]] (presence of 10 or more [[Hepatocellular adenoma|hepatocellular adenomas]]).<ref>{{Cite journal | |||
| author = [[Massimo Roncalli]], [[Amedeo Sciarra]] & [[Luca Di Tommaso]] | |||
| title = Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma | |||
| journal = [[Clinical and molecular hepatology]] | |||
| volume = 22 | |||
| issue = 2 | |||
| pages = 199–211 | |||
| year = 2016 | |||
| month = June | |||
| doi = 10.3350/cmh.2016.0101 | |||
| pmid = 27189732 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Ludger Barthelmes]] & [[Iain S. Tait]] | |||
| title = Liver cell adenoma and liver cell adenomatosis | |||
| journal = [[HPB : the official journal of the International Hepato Pancreato Biliary Association]] | |||
| volume = 7 | |||
| issue = 3 | |||
| pages = 186–196 | |||
| year = 2005 | |||
| month = | |||
| doi = 10.1080/13651820510028954 | |||
| pmid = 18333188 | |||
}}</ref> | |||
* The [[Alpha-fetoprotein|alpha fetoprotein]] may be raised if [[patient]] develops [[hepatocellular carcinoma]].<ref name="fgh">Clinical and laboratory findings of Hepatic adenoma. Scielo 2015. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202013000300012&lng=en&nrm=iso&tlng=en. Accessed on October 16, 2015</ref> | |||
==References== | ==References== | ||
{{reflist|1}} | {{reflist|1}} | ||
Latest revision as of 21:04, 20 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
Patients suffering from hepatocellular adenoma usually have normal liver function tests and normal serum tumor markers. Acute phase reactants may be raised secondary to necrosis or hemorrhage and alkaline phosphatase may be raised in hepatocellular adenomatosis.
Laboratory Findings
- Patients suffering from hepatocellular adenoma usually have normal liver function tests with no elevation in serum tumor markers, such as alpha fetoprotein.[1][2][3]
- The liver function tests may be found abnormal secondary to necrosis or hemorrhage.
- Alkaline phosphatase is raised in patients with hepatocellular adenomatosis (presence of 10 or more hepatocellular adenomas).[4][5]
- The alpha fetoprotein may be raised if patient develops hepatocellular carcinoma.[6]
References
- ↑ Dhingra, Sadhna; Fiel, M. Isabel (2014). "Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics". Archives of Pathology & Laboratory Medicine. 138 (8): 1090–1097. doi:10.5858/arpa.2013-0183-RA. ISSN 0003-9985.
- ↑ Paulette Bioulac-Sage, Sandra Rebouissou, Antonio Sa Cunha, Emmanuelle Jeannot, Sebastien Lepreux, Jean-Frederic Blanc, Helene Blanche, Brigitte Le Bail, Jean Saric, Pierre Laurent-Puig, Charles Balabaud & Jessica Zucman-Rossi (2005). "Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver". Gastroenterology. 128 (5): 1211–1218. PMID 15887105. Unknown parameter
|month=ignored (help) - ↑ Nault, Jean-Charles; Paradis, Valérie; Cherqui, Daniel; Vilgrain, Valérie; Zucman-Rossi, Jessica (2017). "Molecular classification of hepatocellular adenoma in clinical practice". Journal of Hepatology. 67 (5): 1074–1083. doi:10.1016/j.jhep.2017.07.009. ISSN 0168-8278.
- ↑ Massimo Roncalli, Amedeo Sciarra & Luca Di Tommaso (2016). "Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma". Clinical and molecular hepatology. 22 (2): 199–211. doi:10.3350/cmh.2016.0101. PMID 27189732. Unknown parameter
|month=ignored (help) - ↑ Ludger Barthelmes & Iain S. Tait (2005). "Liver cell adenoma and liver cell adenomatosis". HPB : the official journal of the International Hepato Pancreato Biliary Association. 7 (3): 186–196. doi:10.1080/13651820510028954. PMID 18333188.
- ↑ Clinical and laboratory findings of Hepatic adenoma. Scielo 2015. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202013000300012&lng=en&nrm=iso&tlng=en. Accessed on October 16, 2015