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{{Burkitt's lymphoma}} | {{Burkitt's lymphoma}} | ||
{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}}, {{kakbar}} | ||
==Overview== | ==Overview== | ||
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required. | The predominant therapy for Burkitt's lymphoma is [[chemotherapy]]. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required. | ||
==Medical Therapy== | ==Medical Therapy== | ||
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required.<ref name="Cancer.ca">Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015</ref> | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
* Chemotherapeutic regimens for Burkitt's lymphoma include:<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | * [[Chemotherapeutic agent|Chemotherapeutic]] regimens for Burkitt's lymphoma include:<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | ||
* [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Methotrexate]] (CODOX-M)<ref name="pmid29741758">{{cite journal| author=Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K et al.| title=Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab. | journal=Br J Haematol | year= 2018 | volume= 181 | issue= 6 | pages= 782-790 | pmid=29741758 | doi=10.1111/bjh.15262 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29741758 }} </ref> | * [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Methotrexate]] (CODOX-M)<ref name="pmid29741758">{{cite journal| author=Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K et al.| title=Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab. | journal=Br J Haematol | year= 2018 | volume= 181 | issue= 6 | pages= 782-790 | pmid=29741758 | doi=10.1111/bjh.15262 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29741758 }} </ref><ref name="pmid25957391">{{cite journal| author=Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E et al.| title=AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma. | journal=Blood | year= 2015 | volume= 126 | issue= 2 | pages= 160-6 | pmid=25957391 | doi=10.1182/blood-2015-01-623900 | pmc=4497960 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25957391 }} </ref> | ||
* [[Ifosfamide]] {{and}} [[Mesna]] {{and}} [[Etoposide]] {{and}} [[Cytarabine]] (IVAC)<ref name="BortzCoutsouvelis2015">{{cite journal|last1=Bortz|first1=H.|last2=Coutsouvelis|first2=J.|last3=Corallo|first3=C. E.|last4=Spencer|first4=A.|last5=Patil|first5=S.|title=Modifying chemotherapeutic management of a patient with Burkitt's lymphoma and pre-existing motor neurone disease|journal=Journal of Clinical Pharmacy and Therapeutics|volume=40|issue=4|year=2015|pages=483–485|issn=02694727|doi=10.1111/jcpt.12293}}</ref> | * [[Ifosfamide]] {{and}} [[Mesna]] {{and}} [[Etoposide]] {{and}} [[Cytarabine]] (IVAC)<ref name="BortzCoutsouvelis2015">{{cite journal|last1=Bortz|first1=H.|last2=Coutsouvelis|first2=J.|last3=Corallo|first3=C. E.|last4=Spencer|first4=A.|last5=Patil|first5=S.|title=Modifying chemotherapeutic management of a patient with Burkitt's lymphoma and pre-existing motor neurone disease|journal=Journal of Clinical Pharmacy and Therapeutics|volume=40|issue=4|year=2015|pages=483–485|issn=02694727|doi=10.1111/jcpt.12293}}</ref><ref name="pmid25957391">{{cite journal| author=Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E et al.| title=AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma. | journal=Blood | year= 2015 | volume= 126 | issue= 2 | pages= 160-6 | pmid=25957391 | doi=10.1182/blood-2015-01-623900 | pmc=4497960 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25957391 }} </ref> | ||
* [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Dexamethasone]] {{and}} [[Methotrexate]] {{and}} [[Cytarabine]] (Hyper-CVAD) | * [[Cyclophosphamide]] {{and}} [[Vincristine]] {{and}} [[Doxorubicin]] {{and}} [[Dexamethasone]] {{and}} [[Methotrexate]] {{and}} [[Cytarabine]] (Hyper-CVAD)<ref name="pmid20660823">{{cite journal| author=Thomas DA, O'Brien S, Faderl S, Garcia-Manero G, Ferrajoli A, Wierda W et al.| title=Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. | journal=J Clin Oncol | year= 2010 | volume= 28 | issue= 24 | pages= 3880-9 | pmid=20660823 | doi=10.1200/JCO.2009.26.9456 | pmc=2940403 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20660823 }} </ref> | ||
'''CNS prophylaxis''' | '''CNS prophylaxis''' | ||
* There is a high risk that Burkitt's lymphoma will spread to the central nervous system ([[CNS]]) | * There is a high risk that Burkitt's lymphoma will spread to the [[central nervous system]] ([[CNS]]) | ||
* CNS prophylaxis may involve giving [[intrathecal]] chemotherapy, high doses of systemic therapy, or both methods may be used | * CNS prophylaxis may involve giving [[intrathecal]] chemotherapy, high doses of systemic therapy, or both methods may be used<ref name="pmid27025508">{{cite journal| author=González-Barca E, Canales M, Salar A, Ferreiro-Martínez JJ, Ferrer-Bordes S, García-Marco JA et al.| title=Central nervous system prophylaxis with intrathecal liposomal cytarabine in a subset of high-risk patients with diffuse large B-cell lymphoma receiving first line systemic therapy in a prospective trial. | journal=Ann Hematol | year= 2016 | volume= 95 | issue= 6 | pages= 893-9 | pmid=27025508 | doi=10.1007/s00277-016-2648-4 | pmc=4853453 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27025508 }} </ref> | ||
* [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis<ref name="pmid27846613">{{cite journal| author=Peñalver FJ, Sancho JM, de la Fuente A, Olave MT, Martín A, Panizo C et al.| title=Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO). | journal=Haematologica | year= 2017 | volume= 102 | issue= 2 | pages= 235-245 | pmid=27846613 | doi=10.3324/haematol.2016.149120 | pmc=5286932 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27846613 }} </ref> | * [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for [[CNS]] [[prophylaxis]]<ref name="pmid27846613">{{cite journal| author=Peñalver FJ, Sancho JM, de la Fuente A, Olave MT, Martín A, Panizo C et al.| title=Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO). | journal=Haematologica | year= 2017 | volume= 102 | issue= 2 | pages= 235-245 | pmid=27846613 | doi=10.3324/haematol.2016.149120 | pmc=5286932 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27846613 }} </ref> | ||
===Biological therapy=== | ===Biological therapy=== | ||
* [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | * [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma<ref name="pmid7031655">{{cite journal| author=Wiels J, Fellous M, Tursz T| title=Monoclonal antibody against a Burkitt lymphoma-associated antigen. | journal=Proc Natl Acad Sci U S A | year= 1981 | volume= 78 | issue= 10 | pages= 6485-8 | pmid=7031655 | doi= | pmc=349064 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7031655 }} </ref> | ||
* [[Rituximab]] may be added to each of the above chemotherapy regimens<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | * [[Rituximab]] may be added to each of the above [[chemotherapy]] regimens<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref><ref name="pmid20660823">{{cite journal| author=Thomas DA, O'Brien S, Faderl S, Garcia-Manero G, Ferrajoli A, Wierda W et al.| title=Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. | journal=J Clin Oncol | year= 2010 | volume= 28 | issue= 24 | pages= 3880-9 | pmid=20660823 | doi=10.1200/JCO.2009.26.9456 | pmc=2940403 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20660823 }} </ref> | ||
===Stem cell transplant=== | ===Stem cell transplant=== | ||
* A [[stem cell transplant]] may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment.<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | * A [[stem cell transplant]] may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment.<ref name="JacobsonLaCasce2014">{{cite journal|last1=Jacobson|first1=C.|last2=LaCasce|first2=A.|title=How I treat Burkitt lymphoma in adults|journal=Blood|volume=124|issue=19|year=2014|pages=2913–2920|issn=0006-4971|doi=10.1182/blood-2014-06-538504}}</ref> | ||
Latest revision as of 23:26, 21 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.[1]
Chemotherapy
- Chemotherapeutic regimens for Burkitt's lymphoma include:[2]
- Cyclophosphamide AND Vincristine AND Doxorubicin AND Methotrexate (CODOX-M)[3][4]
- Ifosfamide AND Mesna AND Etoposide AND Cytarabine (IVAC)[5][4]
- Cyclophosphamide AND Vincristine AND Doxorubicin AND Dexamethasone AND Methotrexate AND Cytarabine (Hyper-CVAD)[6]
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy, high doses of systemic therapy, or both methods may be used[7]
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis[8]
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma[9]
- Rituximab may be added to each of the above chemotherapy regimens[2][6]
Stem cell transplant
- A stem cell transplant may be offered to patients with recurrent Burkitt's lymphoma or to patients who relapse after the treatment.[2]
References
- ↑ Burkitt lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/burkitt-lymphoma/?region=on Accessed on September 28, 2015
- ↑ 2.0 2.1 2.2 Jacobson, C.; LaCasce, A. (2014). "How I treat Burkitt lymphoma in adults". Blood. 124 (19): 2913–2920. doi:10.1182/blood-2014-06-538504. ISSN 0006-4971.
- ↑ Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K; et al. (2018). "Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab". Br J Haematol. 181 (6): 782–790. doi:10.1111/bjh.15262. PMID 29741758.
- ↑ 4.0 4.1 Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E; et al. (2015). "AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma". Blood. 126 (2): 160–6. doi:10.1182/blood-2015-01-623900. PMC 4497960. PMID 25957391.
- ↑ Bortz, H.; Coutsouvelis, J.; Corallo, C. E.; Spencer, A.; Patil, S. (2015). "Modifying chemotherapeutic management of a patient with Burkitt's lymphoma and pre-existing motor neurone disease". Journal of Clinical Pharmacy and Therapeutics. 40 (4): 483–485. doi:10.1111/jcpt.12293. ISSN 0269-4727.
- ↑ 6.0 6.1 Thomas DA, O'Brien S, Faderl S, Garcia-Manero G, Ferrajoli A, Wierda W; et al. (2010). "Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia". J Clin Oncol. 28 (24): 3880–9. doi:10.1200/JCO.2009.26.9456. PMC 2940403. PMID 20660823.
- ↑ González-Barca E, Canales M, Salar A, Ferreiro-Martínez JJ, Ferrer-Bordes S, García-Marco JA; et al. (2016). "Central nervous system prophylaxis with intrathecal liposomal cytarabine in a subset of high-risk patients with diffuse large B-cell lymphoma receiving first line systemic therapy in a prospective trial". Ann Hematol. 95 (6): 893–9. doi:10.1007/s00277-016-2648-4. PMC 4853453. PMID 27025508.
- ↑ Peñalver FJ, Sancho JM, de la Fuente A, Olave MT, Martín A, Panizo C; et al. (2017). "Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO)". Haematologica. 102 (2): 235–245. doi:10.3324/haematol.2016.149120. PMC 5286932. PMID 27846613.
- ↑ Wiels J, Fellous M, Tursz T (1981). "Monoclonal antibody against a Burkitt lymphoma-associated antigen". Proc Natl Acad Sci U S A. 78 (10): 6485–8. PMC 349064. PMID 7031655.