Burkitt's lymphoma natural history, complications and prognosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Burkitt's lymphoma}} | {{Burkitt's lymphoma}} | ||
{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}}, {{kakbar}} | ||
==Overview== | ==Overview== | ||
The prognosis varies with the age, children have the most favorable prognosis. Burkitt's lymphoma in children is associated with a 5 year survival rate of 90%. The presence of metastasis in [[bone marrow]] or [[CNS]] is associated with a particularly poor prognosis among patients with Burkitt's lymphoma. | The [[prognosis]] varies with the age, children have the most favorable [[prognosis]]. Burkitt's lymphoma in children is associated with a 5 year survival rate of 90%. The presence of [[metastasis]] in [[bone marrow]] or [[CNS]] is associated with a particularly poor [[prognosis]] among patients with Burkitt's lymphoma. | ||
==Complications== | ==Complications== | ||
Common complications of | Common complications of Burkitt's lymphoma include: | ||
*Disruption of teeth | *Disruption of teeth<ref name="pmid18181448">{{cite journal| author=Comfort AO| title=Burkitt's lymphoma of the jaws: role of dental practitioner in management. | journal=Pac Health Dialog | year= 2004 | volume= 11 | issue= 1 | pages= 89-93 | pmid=18181448 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18181448 }} </ref> | ||
*Partial obstruction of airway<ref name="pmid23497670">{{cite journal| author=Aslan G| title=Unusual presentation of sporadic Burkitt's lymphoma originating from the nasal septum: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue= | pages= 60 | pmid=23497670 | doi=10.1186/1752-1947-7-60 | pmc=3599746 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497670 }} </ref> | *[[Airway obstruction|Partial obstruction of airway]]<ref name="pmid23497670">{{cite journal| author=Aslan G| title=Unusual presentation of sporadic Burkitt's lymphoma originating from the nasal septum: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue= | pages= 60 | pmid=23497670 | doi=10.1186/1752-1947-7-60 | pmc=3599746 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23497670 }} </ref> | ||
*Ulceration and | *[[Ulcer|Ulceration]] and [[Drain (surgery)|drainage]]<ref name="pmid25289138">{{cite journal| author=Madabhavi I, Patel A, Revannasiddaiah S, Choudhary M, Anand A, Das P et al.| title=Primary esophageal Burkitt's lymphoma: a rare case report and review of literature. | journal=Gastroenterol Hepatol Bed Bench | year= 2014 | volume= 7 | issue= 4 | pages= 230-7 | pmid=25289138 | doi= | pmc=4185878 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25289138 }} </ref> | ||
*Tumor lysis syndrome<ref name="pmid12634948">{{cite journal| author=Wössmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A| title=Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase. | journal=Ann Hematol | year= 2003 | volume= 82 | issue= 3 | pages= 160-5 | pmid=12634948 | doi=10.1007/s00277-003-0608-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12634948 }} </ref> | *[[Tumor lysis syndrome]]<ref name="pmid12634948">{{cite journal| author=Wössmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A| title=Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase. | journal=Ann Hematol | year= 2003 | volume= 82 | issue= 3 | pages= 160-5 | pmid=12634948 | doi=10.1007/s00277-003-0608-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12634948 }} </ref> | ||
==Prognosis== | ==Prognosis== | ||
* In children, prognosis is good with survival rates >90%<ref name="pmid25258344">{{cite journal| author=Jacobson C, LaCasce A| title=How I treat Burkitt lymphoma in adults. | journal=Blood | year= 2014 | volume= 124 | issue= 19 | pages= 2913-20 | pmid=25258344 | doi=10.1182/blood-2014-06-538504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25258344 }} </ref> | * In children, [[prognosis]] is good with survival rates >90%<ref name="pmid25258344">{{cite journal| author=Jacobson C, LaCasce A| title=How I treat Burkitt lymphoma in adults. | journal=Blood | year= 2014 | volume= 124 | issue= 19 | pages= 2913-20 | pmid=25258344 | doi=10.1182/blood-2014-06-538504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25258344 }} </ref> | ||
* In adults, prognosis is poor, with a 5-year survival rate of 50% and is even worse with [[bone marrow]] or [[CNS]] involvement (>30% 5-year survival rate). | * In adults, [[prognosis]] is poor, with a 5-year survival rate of 50% and is even worse with [[bone marrow]] or [[CNS]] involvement (>30% 5-year survival rate). | ||
==References== | ==References== | ||
Latest revision as of 23:03, 18 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2], Kamal Akbar, M.D.[3]
Overview
The prognosis varies with the age, children have the most favorable prognosis. Burkitt's lymphoma in children is associated with a 5 year survival rate of 90%. The presence of metastasis in bone marrow or CNS is associated with a particularly poor prognosis among patients with Burkitt's lymphoma.
Complications
Common complications of Burkitt's lymphoma include:
- Disruption of teeth[1]
- Partial obstruction of airway[2]
- Ulceration and drainage[3]
- Tumor lysis syndrome[4]
Prognosis
- In children, prognosis is good with survival rates >90%[5]
- In adults, prognosis is poor, with a 5-year survival rate of 50% and is even worse with bone marrow or CNS involvement (>30% 5-year survival rate).
References
- ↑ Comfort AO (2004). "Burkitt's lymphoma of the jaws: role of dental practitioner in management". Pac Health Dialog. 11 (1): 89–93. PMID 18181448.
- ↑ Aslan G (2013). "Unusual presentation of sporadic Burkitt's lymphoma originating from the nasal septum: a case report". J Med Case Rep. 7: 60. doi:10.1186/1752-1947-7-60. PMC 3599746. PMID 23497670.
- ↑ Madabhavi I, Patel A, Revannasiddaiah S, Choudhary M, Anand A, Das P; et al. (2014). "Primary esophageal Burkitt's lymphoma: a rare case report and review of literature". Gastroenterol Hepatol Bed Bench. 7 (4): 230–7. PMC 4185878. PMID 25289138.
- ↑ Wössmann W, Schrappe M, Meyer U, Zimmermann M, Reiter A (2003). "Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase". Ann Hematol. 82 (3): 160–5. doi:10.1007/s00277-003-0608-2. PMID 12634948.
- ↑ Jacobson C, LaCasce A (2014). "How I treat Burkitt lymphoma in adults". Blood. 124 (19): 2913–20. doi:10.1182/blood-2014-06-538504. PMID 25258344.